The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

Al-Attar, Ali M.; Abid, Mushriq

doi:10.1155/2022/6555883

Cited by 10 publications

(13 citation statements)

References 52 publications

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“…However, the abovementioned results were contrary to that of Tehranchi et al (2017), who demonstrated no significant correlation between the VD serum level and external apical root resorption development (55) . Moreover, this result was inconsistent with that of Al-Attar and Abid (2022), who demonstrated a nonsignificant correlation between root resorption and VD serum level after the first three months of orthodontic treatment (13) . A different method of root resorption assessment could be used, as the latter used a periapical radiograph with a digital sensor as opposed to the gold standard for histological investigation in the current study.…”

Section: Discussioncontrasting

confidence: 91%

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Effects of vitamin D deficiency on bone and root resorption post-orthodontic retention in rats

2023

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Background: Orthodontic therapy often causes external root resorption. Serum vitamin D (VD) level is important for tooth mineralization and bone remodeling. This study aimed to test the impact of vitamin D (VD) supplements on bone and root remodelling in a vitamin D (VD) deficient rat model following orthodontic retention. Methods and Material: 30 male Wistar rats were divided into three groups: a control group of 10 rats and two experimental groups of 10 rats each with vitamin D deficiency (VDD) induced by a VD-free diet for 21 days. And a third group with VD supplementAll groups received orthodontic active treatment using a modified orthodontic appliance that applied 50 gm of force for 14 days to move the maxillary right first molar mesially, followed by 7 days of retention and relapse. The VDD group received no intervention, while the VDS group received 40,000 IU/kg of systemic VD3 by intramuscular injection on the first and fifteenth day of orthodontic treatment. Histomorphometric analysis was performed to assess bone and cementum resorption and deposition. Results: The VDD group exhibited a significant increase in bone and root resorption and a decrease in bone deposition and ce-mentum deposition ratio. In addition, bone deposition and the ratio of cementum deposition were substantially greater in the VDS group compared to the control group. Conclusion: VDD may increase bone and root cementum resorption and decrease deposition after orthodontic retention, which may play a significant role in relapse after retention. Prior to beginning orthodontic treatment, routine VD screening may be beneficial.

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Section: Discussioncontrasting

confidence: 91%

“…A correlation was observed between root resorption and VD receptor gene polymorphism (12) . However, the relationship of VDD and root resorption was inconclusive, probably because of published data with short-term follow-up (13) .…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D deficiency on bone and root resorption post-orthodontic retention in rats

2023

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“…After applying a linear regression model to control for the effect of confounders, they found no significant correlation between serum levels of vitamin D and EARR, which was in line with the present findings. In a recent study, Al-Attar and Abid [ 24 ] evaluated the serum level of vitamin D3 and detected no significant correlation between the serum level of vitamin D and root resorption due to orthodontic treatment. However, it should be noted that they only evaluated patients for a 3-month period at the onset of treatment during the leveling and alignment phase, and thus, their results cannot reflect the effect of the entire course of orthodontic treatment; whereas, the present study evaluated pre- and post-treatment radiographs of patients who underwent comprehensive orthodontic treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of Serum Level of Vitamin D on External Apical Root Resorption in Maxillary Anterior Teeth in Patients under Fixed Orthodontic Treatment

Azizi

Karami

Golshah

et al. 2022

International Journal of Dentistry

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Introduction. This study aimed to assess the effect of serum level of vitamin D on external apical root resorption (EARR) in maxillary anterior teeth in patients under fixed orthodontic treatment. Materials and Methods. This retrospective cohort was conducted on patients under fixed orthodontic treatment who were between 12 to 30 years of age. All patients underwent the same treatment technique by the same orthodontist using a 0.022 MBT system. EARR in maxillary anterior teeth was evaluated on pre- and postoperative panoramic radiographs. Blood samples were also collected from patients, and their serum level of vitamin D was measured after the completion of treatment. Data were analyzed by independent t-test and Chi-square test (alpha = 0.05). Results. A reduction in root length was noted in all patients, which was significant ( P < 0.0001 ); 75% of patients showed EARR in at least one maxillary incisor. EARR had no significant correlation with the serum level of vitamin D ( P = 0.423 ). Conclusions. Serum level of vitamin D had no significant correlation with the occurrence of EARR. However, the high prevalence of EARR calls for measures to minimize it.

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“…According to the Al-Attar et al study, 39 the sample size for this study was estimated and based on the ability to distinguish a clinically relevant difference in the orthodontic tooth (primary outcome) in the three groups of the trial, with a significance level of .05 and 80% power. Based on the calculation, at least 23 patients had to be assigned to each group.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Farzanegan

Nour

Mobarhan

et al. 2023

Journal of Advanced Oral Research

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Aim: One of the problems that orthodontists commonly face is the prolonged duration of the treatment. Therefore, it is important to find an effective method to increase the rate of orthodontic tooth movement (OTM). This study aimed to evaluate the effectiveness of oral administration of vitamin D3 on OTM rates in humans. Materials and Methods: In this randomized clinical trial study, we selected 29 healthy women aged 18–25 years who sought orthodontic treatment and required bilateral maxillary first premolar extraction. Participants were tested to measure the blood levels of vitamin D3 and, based on the outcomes, were divided into three groups: control (without vitamin D3 deficiency; N = 10), placebo ( N = 9), and experiment ( N = 10), both with vitamin D3 deficiency. Subjects of the last two groups, who were randomly assigned, received 50,000 IU (International Unit) vitamin D3 pearls (Dana Pharmaceutical Company, Tabriz, Iran) or a placebo every 2 weeks for 2 months. Inclusion criteria were patients requiring bilateral extraction of the first premolar in the maxilla. The canines were retracted by nickel-titanium (NiTi) coil springs into the extraction sites. At the beginning, after 1 and 2 months, the distance between canine and lateral teeth on both sides was measured to calculate OTM. Results: In the first month ( t (1–2)), the mean values of OTM in the placebo group were higher than the other groups. However, during the second month ( t (2–3)) and overall ( t (1–3)), the experiment group showed a higher OTM. The experiment and control groups were statistically different in all three time periods ( P-value < .05). The difference between the experiment and placebo groups was only significant in t (2–3) ( P-value < .05). Whereas the placebo and control groups showed a significant difference in t (1–2) ( P-value < .05). Conclusion: Vitamin D3 deficiency seems to increase OTM. Receiving oral supplements of vitamin D3 may not have much effect on increasing the level of vitamin D3. The lowest OTM rate was observed in the control group.

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The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

Cited by 10 publications

References 52 publications

Effects of vitamin D deficiency on bone and root resorption post-orthodontic retention in rats

Effects of vitamin D deficiency on bone and root resorption post-orthodontic retention in rats

Effect of Serum Level of Vitamin D on External Apical Root Resorption in Maxillary Anterior Teeth in Patients under Fixed Orthodontic Treatment

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

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