The effect of vitamin <scp>D</scp> on nonspecific low back pain

Sandoughi, Mahnaz; Zakeri, Zahra; Mirhosainee, Zahra; Mohammadi, Mehdi; Shahbakhsh, Sogol

doi:10.1111/1756-185x.12172

Cited by 28 publications

(40 citation statements)

References 34 publications

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“…Our data were in agreement with previous research, which reported that both dark skin and less pigmented skin need three to six times more sun light exposure to produce a similar ratio of vitamin D 26. In addition, other studies confirm our results that both longer duration of sunlight exposure and skin left exposed by different dressing styles were significantly associated with vitamin D levels 107–110…”

Section: Discussionsupporting

confidence: 93%

Mechanical factors and vitamin D deficiency in schoolchildren with low back pain: biochemical and cross-sectional survey analysis

Alghadir¹,

Gabr²,

Al-Eisa³

2017

JPR

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ObjectiveThis study was designed to evaluate the role of vitamin D, muscle fatigue biomarkers, and mechanical factors in the progression of low back pain (LBP) in schoolchildren.BackgroundChildren and adolescents frequently suffer from LBP with no clear clinical causes, and >71% of schoolchildren aged 12–17 years will show at least one episode of LBP.Materials and methodsA total of 250 schoolchildren aged 12–16 years were randomly enrolled in this study. For all schoolchildren height, weight, percentage of daily sun exposure and and areas of skin exposed to sun, method of carrying the bag, and bag weight and type were recorded over a typical school week. Pain scores, physical activity (PA), LBP, serum vitamin 25(OH)D level, serum bone-specific alkaline phosphatase, creatine kinase (CK), and lactate dehydrogenase (LDH) activities and calcium (Ca) concentrations were estimated using prevalidated Pain Rating Scale, modified Oswestry Low Back Pain Disability Questionnaire, short-form PA questionnaire, and colorimetric and immunoassay techniques.ResultsDuring the period of October 2013–May 2014, LBP was estimated in 52.2% of the schoolchildren. It was classified into moderate (34%) and severe (18%). Girls showed a higher LBP (36%) compared with boys (24%). In schoolchildren with moderate and severe LBP significantly higher (P=0.01) body mass index, waist, hip, and waist-to-hip ratio measurements were observed compared with normal schoolchildren. LBP significantly correlated with less sun exposure, lower PA, sedentary activity (TV/computer use), and overloaded school bags. In addition, schoolchildren with severe LBP showed lower levels of vitamin 25(OH)D and Ca and higher levels of CK, LDH, and serum bone-specific alkaline phosphatase compared with moderate and healthy schoolchildren. Stepwise regression analysis revealed that age, gender, demographic parameters, PA, vitamin D levels, Ca, CK, and LDH associated with ~56.8%–86.7% of the incidence of LBP among schoolchildren.ConclusionIn children and adolescents, LBP was shown to be linked with limited sun exposure, inadequate vitamin D diets, adiposity, lower PA, sedentary lifestyles, vitamin 25 (OH) D deficiency, and lower levels of Ca, CK, and LDH.

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Section: Discussionsupporting

confidence: 93%

Mechanical factors and vitamin D deficiency in schoolchildren with low back pain: biochemical and cross-sectional survey analysis

Alghadir¹,

Gabr²,

Al-Eisa³

2017

JPR

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“…Human population studies have shown that plasma levels of vitamin D are inversely associated with risk for CLBP 159. However, results from a double-blind RCT of 53 patients aged 18–40 years with nonspecific CLBP showed no significant effect of vitamin D supplementation (50,000 IU) in decreasing the pain visual analog scale score of the patients 160. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.…”

Section: Vitamin D and Inflammatory Diseasesmentioning

confidence: 98%

Vitamin D and inflammatory diseases

Yin¹,

Agrawal²

2014

JIR

233

113

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Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed.

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“…Los cambios medios en el dolor crónico fueron de 2.3 ± 2.6, 95% CI = 1.3-3.4 en el grupo de VD y de 3.3± 3.6, 95% CI = 0.61-2.55 en el de placebo. Concluyen que, de acuerdo con estos resultados, tanto el tratamiento con D3 como placebo mejoraron el dolor lumbar crónico y que no hubo diferencias significativas entre los grupos 42 . El anterior artículo fue criticado por varias razones: tener algunas fallas metodológicas en su diseño, en el grupo de pacientes solo un porcentaje tenían deficiencia de VD, la intensidad del dolor fue significativamente más alta en el grupo placebo que en el de VD, a pesar del tratamiento no se logró siquiera normalizar los niveles de VD y se utilizaron pruebas estadísticas inapropiadas, lo cual afecta la validez interna y externa del estudio 43 .…”

Section: Evidencia En Contraunclassified

Dolor músculo esquelético y vitamina D

Salinas

2015

Rev Col Med Fis Reh

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The effect of vitamin D on nonspecific low back pain

Cited by 28 publications

References 34 publications

Mechanical factors and vitamin D deficiency in schoolchildren with low back pain: biochemical and cross-sectional survey analysis

Mechanical factors and vitamin D deficiency in schoolchildren with low back pain: biochemical and cross-sectional survey analysis

Vitamin D and inflammatory diseases

Dolor músculo esquelético y vitamina D

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