The effect of voluntary wheel running on 129/SvEvTac and C3H/Ibg alcohol consumption

Booher, Winona C.; Hoft, Nicole R.; Ehringer, Marissa A.

doi:10.1016/j.alcohol.2018.10.007

Cited by 4 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results from the separate studies of voluntary 2BC and voluntary wheel running by Belknap et al, Yoneyama et al, and Lerman et al support this hypothesis. Similarly, findings from the three strains (male and female C7BL/6Ibg, C3H/Ibg and 129/SvEvTac) examined in the Ehringer et al and Booher et al studies provide general support for this idea. The female C57BL/Ibg mice consumed the greatest amount of alcohol and ran the farthest distance.…”

Section: Role Of Genetics In Auds and Exercisementioning

confidence: 66%

“…In 129/SvEvTac mice, both sexes showed reduced alcohol consumption with both a locked wheel and a free running wheel. However, a sex difference was observed in C3H/Ibg mice, where the males showed a decrease in alcohol consumption with a locked wheel and free wheel, but the C3H/Ibg females showed no differences in alcohol intake among any of the three groups . Finally, Brager and Hammer demonstrated that aged Syrian male hamsters (24 months of age) with access to a free running wheel, as opposed to a locked wheel, will significantly decrease their 20% alcohol consumption and preference .…”

Section: Behavioral Models Investigating the Interaction Between Wheementioning

confidence: 96%

“…The female C57BL/Ibg mice consumed the greatest amount of alcohol and ran the farthest distance. This pattern was followed with the remainder of the mice except for the male C57BL/6Ibg mice, which consumed more alcohol than the C3H/Ibg and 129/SvEvTac strains of mice but only ran farther than the 129/SvEvTac mice . Collectively, there remain very few studies that have carefully examined both sex and genetics within the context of a single behavioral paradigm, so additional research is needed to clarify the relative importance of each factor.…”

Section: Role Of Genetics In Auds and Exercisementioning

confidence: 99%

“…Numerous studies in rodents have provided evidence for an interaction between voluntary wheel running and alcohol consumption . In a recent review, Hallgreen et al pointed out that, “physical exercise is widely regarded as “medicine” for the prevention and treatment of myriad somatic health conditions.” However, the effectiveness of physical activity to treat AUDs remains understudied.…”

Section: Behavioral Models Investigating the Interaction Between Wheementioning

confidence: 99%

“…Numerous studies in rodents have provided evidence for an interaction between voluntary wheel running and alcohol consumption. [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74] In a recent review, Hallgreen et al 75 pointed out that, "physical exercise is widely regarded as "medicine" for the prevention and treatment of myriad somatic health conditions." 75 alcohol 2BC and DID (20% alcohol).…”

Section: Behavioral Models Investigating the Interaction Between Whmentioning

confidence: 99%

See 4 more Smart Citations

Behavioral and neuronal interactions between exercise and alcohol: Sex and genetic differences

Booher

Martínez

Ehringer

2020

Genes Brain and Behavior

Self Cite

View full text Add to dashboard Cite

Alcohol use disorders (AUDs) lead to early death and many devastating consequences for individuals, families and society. Currently, few effective treatments are available, but emerging research suggests exercise might be beneficial in some individuals. To develop the most effective exercise treatment program, more research on intensity, type, timing, stage of addiction, drug involved, sex of subject and subject population is needed. This review highlights the complexity of the interaction between alcohol behaviors and exercise, with a focus on the role of sex and genetics. Moreover, we describe a variety of rodent models used to investigate the neuronal physiology changes that underlie alcohol consumption and exercise. Specifically, current data indicate that moderate exercise may ameliorate neuronal damage caused by alcohol consumption. Additionally, we describe studies of rodent models in the context of hedonic substitution to draw broad conclusions about shared underlying neurobiological mechanisms. Until recently, most studies in rodents were performed only in males, and few studies have utilized different genetic strains of mice or rats. Comparing similar behavioral paradigms across sex and strain, it has become clear that major sex and genetic differences exist for each behavioral context alone (alcohol consumption and exercise) and combined. Therefore, future research in this area should be developed with careful study design and attention to address both of these factors.

show abstract

Section: Role Of Genetics In Auds and Exercisementioning

confidence: 66%

Section: Behavioral Models Investigating the Interaction Between Wheementioning

confidence: 96%

Section: Role Of Genetics In Auds and Exercisementioning

confidence: 99%

Section: Behavioral Models Investigating the Interaction Between Wheementioning

confidence: 99%

Section: Behavioral Models Investigating the Interaction Between Whmentioning

confidence: 99%

See 3 more Smart Citations

Behavioral and neuronal interactions between exercise and alcohol: Sex and genetic differences

Booher

Martínez

Ehringer

2020

Genes Brain and Behavior

Self Cite

View full text Add to dashboard Cite

show abstract

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice

Reguilón,

Ferrer-Pérez,

Manzanedo

et al. 2023

Psychopharmacology

View full text Add to dashboard Cite

Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased ethanol seeking and consumption, accompanied by activation of the neuroinflammatory response. However, a resilient response can be potentiated through physical exercise in the form of voluntary wheel running (VWR) during or after exposure to social stress. Therefore, the aim of this study was to test whether physical exercise during adolescence prior to being exposed to SD can enhance resilience to the increase in ethanol intake. Methods Male mice had access to VWR during adolescence and the effects of social defeat (4 sessions every 72 h) on oral ethanol self-administration (SA) was evaluated. Based on the social interaction test, mice were classified as resilient or susceptible to depressive-like behavior. Two weeks after the last encounter, mice were subjected to the drinking in the dark and oral ethanol SA paradigms. Mice were then sacrificed to measure brain-derived neurotrophic factor (BDNF) levels in the striatum and hippocampus. Results As expected, susceptible mice increased ethanol intake in the oral SA protocol. However, susceptible mice in the exercise condition did not increase ethanol intake, showing similar consumption and motivation for ethanol than the control and resilient groups. On the other hand, decreased BDNF levels were observed in susceptible mice in both experimental conditions compared to the control groups after ethanol SA. Conclusions The pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake.

show abstract

Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Booher

Hall

Thomas

et al. 2021

Genes Brain and Behavior

Self Cite

View full text Add to dashboard Cite

High and Low Activity strains of mice (displaying low and high anxiety-like behavior, respectively) with 7.8-20 fold differences in open-field activity were selected and subsequently inbred to use as a genetic model for studying anxiety-like behavior in mice (DeFries et al., 1978, Behavior Genetics, 8:3-13). These strains exhibited differences in other anxiety-related behaviors as assessed using the light-dark box, elevated plus-maze, mirror chamber, and elevated square-maze tests (Henderson et al., 2004, Behavior Genetics, 34: 267-293). The purpose of these experiments was three-fold. First, we repeated a 6-day behavioral battery using updated equipment

show abstract

The effect of voluntary wheel running on 129/SvEvTac and C3H/Ibg alcohol consumption

Cited by 4 publications

References 48 publications

Behavioral and neuronal interactions between exercise and alcohol: Sex and genetic differences

Behavioral and neuronal interactions between exercise and alcohol: Sex and genetic differences

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice

Anxiety‐related defensive behavioral responses in mice selectively bred for High and Low Activity

Contact Info

Product

Resources

About