The effect of warfarin on the attachment of bone to hydroxyapatite-coated and uncoated porous implants.

Callahan, Bert C.; Lisecki, Edward J.; Banks, Ron; Dalton, Jeanette E.; Cook, Stephen D.; Wolff, James D.

doi:10.2106/00004623-199502000-00008

Cited by 60 publications

(10 citation statements)

References 3 publications

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“…Recently, pharmacological agents, such as warfarin and non‐steroid anti‐inflammatory drugs, were proposed to enhance bone formation and healing on an implant surface 8, 9. In addition, antioxidants such as quercetin and α‐lipoic acid inhibit osteoclast differentiation by reducing the OPG/RANK/RANKL pathway through down‐regulation of NF‐κB translocaiton 10, 11.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment

Lee¹,

Lee²,

Bhattarai³

et al. 2010

Cell Biochemistry & Function

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Titanium is biocompatible with bodily tissues. However, the formation of ROS on the titanium surfaces might have negative response of the activity of the surroundings cells. Terrein was isolated from Penicullium sp. 20135 and found to reduce the effects of LPS-induced inflammation. This study examined the role of Terrein on the biocompatibility of titanium to determine if it can help improve osseointegration. MC-3T3 E1 cells were grown on titanium surfaces. The biocompatibility of Terrein was examined by adding it directly to the culture media at the indicated concentration. The cells on the titanium surface produced excessive ROS and decreased the activity of Cu/Zn SOD and Mn SOD. Moreover, the cells had higher activity towards oxidative stress molecules, such as MAPK, FAK and iNOS expression. In addition, MC-3T3 E1 osteoblast-like cells promoted osteoclast differentiation but reduced osteoblast differentiation and mineralization on the titanium surface. Interestingly, the cells given the Terrein treatment showed higher resistance towards oxidative stress through the up-regulation of ERK1/2 and FAK activity but the down-regulation of SAPK/JNK and iNOS activity. Moreover, Terrein promoted osteoblast differentiation and bone mineralization to elevate the activity of ALP, SPARC and down-regulate RANKL expression after blocking NF-κB translocation from the cytosol to the nucleus. In conclusion, the presence of Terrein on titanium surfaces increases osteoblast cell growth without inflammation. Moreover, Terrein, as a putative antioxidant agent, may enhance osseointegration by decreasing the level of ROS and having a potentially synergistic effect on osteoblast differentiation.

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Section: Introductionmentioning

confidence: 99%

Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment

Lee¹,

Lee²,

Bhattarai³

et al. 2010

Cell Biochemistry & Function

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show abstract

“…Factors inhibiting osseointegration include excessive implant mobility, radiation therapy and pharmacological agents such as cyclosporine A, methotrexate, warfarin, low molecular weight heparins, non-steroid anti-inflammatory drugs and patients' related factors such as osteoporosis, rheumatoid arthritis, advanced age, smoking, renal insufficiency etc 17,19 . Thromboprophylaxis is necessary postoperatively in the majority of the Orthopaedic patients and the main and most common weapon for this is still LMWH 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Thromboprophylaxis is necessary postoperatively in the majority of the Orthopaedic patients and the main and most common weapon for this is still LMWH 20 . Unfortunately there is evidence for these drugs that they have deleterious effect on bone healing and osseointegration procedures 19,20 . Although the exact mechanism for this effect of LMWH on bone biology is not clear, it seems that LMWH reduce cancellous bone volume, affecting osteoblasts and human mesenchymal stromal cells in the early stages of bone healing 21,22 .…”

Section: Discussionmentioning

confidence: 99%

The effect of a new oral anticoagulant (Rivaroxaban) on implants pull-out strength. An experimental study in rats

Kapetanou

Savvidis

Potoupnis

et al. 2017

JFSF

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“…The bone models were imported into reverse-engineering software4 and coordinate systems were assigned based on local anatomical landmarks of the patella and femur [13, 16]. Femoral coordinates were applied such that the mediolateral axis (x-axis) passed through the center of the lateral and medial femoral condyles with the femoral origin located at the mid-point between the condyles (Fig.…”

Section: Methodsmentioning

confidence: 99%

Normal patellofemoral kinematic patterns during daily activities in dogs

et al. 2016

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BackgroundPatellar abnormalities are a common cause of pain and lameness in dogs; however, in vivo the relative motion between the femur and patella in dogs is not well described. The objective of this study was to define normal in vivo sagittal plane patellofemoral kinematics in three axes of motion using non-invasive methods. We hypothesized patellofemoral alignment in the sagittal plane would tightly correlate with the femorotibial flexion angle. Six healthy dogs without orthopedic disease underwent computed tomography (CT) of their hind limbs to create 3-D models of the patella and femur. Normal stifle joint motion was captured via flat-panel imaging while each dog performed a series of routine activities, including sitting, walking, and trotting. The 3-D models of the patella and femur were digitally superimposed over the radiographic images with shape-matching software and the precise movement of the patella relative to the femur was calculated.ResultsAs the femorotibial joint flexed, the patellofemoral joint also flexed and the patella moved caudally and distally within the femoral trochlea during each activity. Patellar flexion and distal translation during walk and sit were linearly coupled with the femorotibial flexion angle. Offset was evident while trotting, where patella poses were significantly different between early and late swing phase (p ≤ 0.003). Patellar flexion ranged from 51 to 6° while trotting. The largest flexion angle (92°) occurred during sit. The patella traversed the entire proximodistal length of the femoral trochlea during these daily activities.ConclusionsUsing single-plane flat-panel imaging, we demonstrated normal in vivo patellofemoral kinematics is tightly coupled with femorotibial kinematics; however, trot kinematic patterns did not follow the path defined by walking and stand-to-sit motions. Our normal data can be used in future studies to help define patellofemoral joint kinematics in dogs with stifle abnormalities.

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The effect of warfarin on the attachment of bone to hydroxyapatite-coated and uncoated porous implants.

Cited by 60 publications

References 3 publications

Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment

Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment

The effect of a new oral anticoagulant (Rivaroxaban) on implants pull-out strength. An experimental study in rats

Normal patellofemoral kinematic patterns during daily activities in dogs

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