The effect of warm ischemia at uterus transplantation in a rat model

Díaz-García, César; Akhi, Shamima N.; Martínez-Varea, Alicia; Brännström, Mats

doi:10.1111/aogs.12027

Cited by 63 publications

(38 citation statements)

References 34 publications

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“…The insufficiency of basic studies in this field was pointed out, and since then, basic research using animal species was started. The animal experiments regarding UTx have been conducted on small animals, such as mice, rats, and rabbits, large animals (including pigs and sheep), and non‐human primates like monkeys and baboons . Many results regarding transplantation techniques, postoperative management, immunosuppression methods, and so on have been obtained …”

Section: Basic Animal Researchmentioning

confidence: 99%

“…The animal experiments regarding UTx have been conducted on small animals, such as mice, [12][13][14][15][16] rats, [17][18][19][20][21][22] and rabbits, [23][24][25][26] large animals (including pigs [27][28][29][30][31] and sheep [32][33][34][35][36][37][38][39][40], and non-human primates like monkeys [41][42][43][44][45][46][47][48] and baboons. [49][50][51][52] Many results regarding transplantation techniques, postoperative management, immunosuppression methods, and so on have been obtained.…”

Section: Basic Animal Researchmentioning

confidence: 99%

See 1 more Smart Citation

Uterus transplantation: Toward clinical application in Japan

Suganuma

Hayashi

Kisu³

et al. 2017

Reprod Medicine & Biology

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BackgroundIn recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be considered through both the history of UTx technology development in the world and future prospects.MethodsRecent information on UTx was collected via a literature survey and the Internet.ResultsBasic research using various animals has been done mainly since 2000. In 2014, the world's first UTx baby was born in Sweden. In total, 24 UTx procedures have been performed at 10 institutes in nine countries and five births were obtained (as of May, 2017). In Japan, the “Project Team for Uterus Transplantation” initiated UTx experiments in 2008 and the “Japan Society for Uterus Transplantation” was organized in March, 2014. In the rest of the world, the “International Society for Uterus Transplantation” was established in January, 2016.ConclusionUterus transplantation is still under development as a reproductive medicine tool and organ transplant procedure. A collaborative system that is not limited by facilities and specialties should strive to build an “all‐Japan” team.

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Section: Basic Animal Researchmentioning

confidence: 99%

Section: Basic Animal Researchmentioning

confidence: 99%

Uterus transplantation: Toward clinical application in Japan

Suganuma

Hayashi

Kisu³

et al. 2017

Reprod Medicine & Biology

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“…22 In separate experiments, it was found that the uterus is an organ, i.e., fairly resistant to warm ischemia. 23…”

Section: Ratmentioning

confidence: 99%

Uterus Transplantation: An Update and Preparations for Introduction in India

Dahm‐Kähler¹,

Brännström²

2016

International Journal of Infertility &Amp; Fetal Medicine

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“…A total of 25 rats were initially included, but two rats of the UTx-nonTAC animals were found dead on postoperative day 1 (major intra-abdominal bleeding in both cases), and these were excluded from the experiments. Fourteen days after surgery, all the animals underwent a midline laparotomy, and the uteri were evaluated according to a previous validated scale to assess rejection of a murine uterine allograft (28). Uterine samples were collected for histology, immunohistochemistry, and analysis of mRNA expression.…”

Section: Animals and Experimental Designmentioning

confidence: 99%