The effect of week-long infusion of propranolol, via an osmotic minipump, on blood pressure, heart rate and vascular responses in spontaneously hypertensive rats

Abstract

Propranolol was infused in SHR subcutaneously for 7 days at two concentrations (either 3.75 or 7.5 mg kg-1 day) via a minipump. Mean blood pressure and heart rate measured under pentobarbitone anaesthesia on day 7 after implantation showed a significant dose-dependent decrease in both propranolol-treated groups. In the low-dose propranolol-treated rats, there was no change in contractile responses to phenylephrine over controls. In rats receiving the higher dose of propranolol there was a significant increase in the response to phenylephrine. There was no change in the relaxation response of any of the groups to isoprenaline. The results indicate that propranolol, while lowering blood pressure and heart rate, is also modifying the alpha-receptor response of the vascular wall in the spontaneously hypertensive rat.

Retracted: Propranolol suppresses HUVEC viability, migration, VEGF expression, and promotes apoptosis by downregulation of miR‐4295

“…[5][6][7][8] Since oral propranolol is first reported to treat IH in 2008, 5 a large number of clinical studies (case reports and case series reports) have evaluated its efficacy and safety. 14,15 Propranolol is lipid soluble and metabolized by the liver after oral administration. 4,12 Propranolol, a non-selective β-blocker, is first discovered by British scientist James W. Black in 1964.…”

“…Propranolol, a non‐selective β‐blocker, is first discovered by British scientist James W. Black in 1964 . It works through blocking β‐adrenergic receptors (β1 and β2) to decrease blood pressure, cardiac contractility, and heart rate . Propranolol is lipid soluble and metabolized by the liver after oral administration .…”

“…12,13 It works through blocking β-adrenergic receptors (β1 and β2) to decrease blood pressure, cardiac contractility, and heart rate. 14,15 Propranolol is lipid soluble and metabolized by the liver after oral administration. 16 Moreover, a report suggested that propranolol has sodium channel blocking effects, little intrinsic sympathomimetic activity, and strong membrane stabilizing activity.…”