The effect of weight loss after bariatric surgery on albuminuria

Agrawal, Varun; Khan, I; Rai, Bhuvnesh; Krause, Kevin R.; Chengelis, David L.; Zalesin, Kerstyn C.; Rocher, Leslie L.; McCullough, Peter A.

doi:10.5414/cnp70194

Cited by 64 publications

(34 citation statements)

References 0 publications

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“…As was the case with a number of other similar studies, 3,12,19,20 another limitation of our study was the use of a single ACR measurement to diagnose normo-, micro-and macroalbuminuria. It is worth noting that the majority of patients from our study had established nephropathy prior to surgery; however, it is possible that some of the patients may have been misclassified.…”

Section: Discussionmentioning

confidence: 92%

“…3,12,19,20 The small size of our study group also acts as a limitation. This was largely due to insufficient recordings of surgery dates and ACR measurements prior to surgery.…”

Section: Discussionmentioning

confidence: 97%

“…This was largely due to insufficient recordings of surgery dates and ACR measurements prior to surgery. However, similar studies 3,12,19,20 had comparable limitations with relatively small sample sizes. Large randomized clinical trials are needed to more definitively assess the effects of bariatric surgery and weight loss on renal function.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15][16][17][18] The effects of bariatric surgery on renal function are not well defined. Two studies have shown that gastric bypass may lead to improvement in albuminuria levels, 3,19 and two other studies have shown improvements with biliopancreatic diversion (BPD). 12,20 In Australia, the majority of bariatric surgery is laparoscopic gastric banding (LAGB).…”

Section: Introductionmentioning

confidence: 99%

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Improvement in albuminuria in patients with type 2 diabetes after laparoscopic adjustable gastric banding

Stephenson

Jandeleit‐Dahm

Balkau

et al. 2013

Diabetes and Vascular Disease Research

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Purpose: To determine the effects of laparoscopic adjustable gastric banding (LAGB) on albuminuria in patients with obesity, type 2 diabetes mellitus (T2DM) and established diabetic nephropathy. Methods: A retrospective analysis of clinical records from a tertiary diabetes service identified obese patients with T2DM who had micro-or macroalbuminuria prior to LAGB surgery. Clinical data from follow-up appointments including albuminuria were analysed. Results: A total of 23 T2DM patients were included in the final study. Of 7 patients with macroalbuminuria at baseline, 2 reverted to normoalbuminuria, 2 reverted to microalbuminuria and 3 remained with macroalbuminuria on their final recording in the 36-month period of follow-up. Of 16 patients with microalbuminuria, 9 reverted to normoalbuminuria, while 6 remained with microalbuminuria. Conclusion: This study demonstrates significant improvements in albuminuria in patients with established diabetic nephropathy following LAGB. These results suggest the potential for LAGB to improve or reverse renal damage in patients with T2DM.

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Section: Discussionmentioning

confidence: 92%

“…3,12,19,20 The small size of our study group also acts as a limitation. This was largely due to insufficient recordings of surgery dates and ACR measurements prior to surgery.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improvement in albuminuria in patients with type 2 diabetes after laparoscopic adjustable gastric banding

Stephenson

Jandeleit‐Dahm

Balkau

et al. 2013

Diabetes and Vascular Disease Research

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“…Agrawal et al (30) reported that there was a significant decrease in urinary albumin-creatinine ratio in patients who had microalbuminuria and underwent Roux-en-Y gastric bypass surgery (median urinary albumin-creatinine ratio 66 mg/g [39 to 106 mg/g] to 13 mg/g [8 to 21 mg/g]). Data related to patients with microalbuminuria alone were not reported in studies that had both patients with normoalbuminuria and microalbuminuria (26 -29).…”

Section: Study Outcomesmentioning

confidence: 99%

Weight Loss Interventions in Chronic Kidney Disease

Navaneethan

Yehnert²,

Moustarah

et al. 2009

Clinical Journal of the American Society of Nephrology

345

192

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Background and objectives: Obesity is an independent risk factor for development and progression of chronic kidney disease (CKD). We conducted a systematic review to assess the benefits of intentional weight loss in patients with nondialysis-dependent CKD and glomerular hyperfiltration.Design, setting, participants, & measurements: We searched MEDLINE, SCOPUS, and conference proceedings for randomized, controlled trials and observational studies that examined various surgical and nonsurgical interventions (diet, exercise, and/or antiobesity agents) in adult patients with CKD. Results were summarized using random-effects model.Results

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