This empirical study aims to design and test a research model that investigates the effect of job insecurity as a moderator of the relationships between perceived employability and employee well-being (work engagement). It also measures the impact of perceived employability on work engagement. Data were gathered from full-time frontline workers employed in five-star hotels in Northern Cyprus to test the study variables; the partial least square structural equation model (PLS-SEM) was applied and supported the research hypotheses. In line with the study predictions and findings from previous literature, perceived employability was found to have a significant positive impact on work engagement. The result revealed that, as a hindrance stressor, job insecurity negatively affects the relationship between perceived employability and work engagement. The findings of this study provide some insights concerning employability’s importance as well as influencing factors on employees’ job selection and their attitudes during job performance in the organizations. The knowledge gathered in this research is a source for stressing the value of employability in developing professional skills and professional involvement, as well as for reducing the perception of job insecurity, especially in the tourism industry, which has a delicate and sensitive structure. The implications of the empirical findings are discussed and future research directions are offered.