The Effect of Yoga Interventions on Cancer-Related Fatigue and Quality of Life for Women with Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

O’Neill, Meagan; Samaroo, Dominic; Lopez, Christopher A.; Tomlinson, George; Mina, Daniel Santa; Sabiston, Catherine M.; Culos-Reed, S. Nicole; Alibhai, Shabbir M.H.

doi:10.1177/1534735420959882

Cited by 43 publications

(51 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, higher expression levels of Flt-3 ligand have been linked to an autoimmune response and to chronic inflammatory responses in the lung, central nervous system, and gastrointestinal tract [38]. By lessening inflammation and fatigue and improving mood, yoga is an ideal exercise that can be modified for individuals with a sedentary lifestyle or functional limitations [11,16,28,[39][40][41]. Our pilot data are consistent with those of previous retrospective studies demonstrating the beneficial effects of yoga on several psychological and QoL outcomes, add granularity at the molecular level, and identify putative inflammatory markers for future research.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial

Kaushik

Shah²,

Mukherjee³

et al. 2021

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Background Diagnosis and treatment of prostate cancer is associated with anxiety, fear, and depression in up to one-third of men. Yoga improves health-related quality of life (QoL) in patients with several types of cancer, but evidence of its efficacy in enhancing QoL is lacking in prostate cancer. Methods In this randomized controlled study, 29 men newly diagnosed with localized prostate cancer were randomized to yoga for 6 weeks (n = 14) or standard-of-care (n = 15) before radical prostatectomy. The primary outcome was self-reported QoL, assessed by the Expanded Prostate Index Composite (EPIC), Functional Assessment of Cancer Therapy-Prostate (FACT-P), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT–F), Functional Assessment of Cancer Therapy-General (FACT-G) at baseline, preoperatively, and 6 weeks postoperatively. Secondary outcomes were changes in immune cell status and cytokine levels with yoga. Results The greatest benefit of yoga on QoL was seen in EPIC-sexual (mean difference, 8.5 points), FACIT-F (6.3 points), FACT-Functional wellbeing (8.6 points), FACT-physical wellbeing (5.5 points), and FACT-Social wellbeing (14.6 points). The yoga group showed increased numbers of circulating CD4+ and CD8+ T-cells, more production of interferon-gamma by natural killer cells, and increased Fc receptor III expression in natural killer cells. The yoga group also showed decreased numbers of regulatory T-cells, myeloid-derived suppressor cells, indicating antitumor activity, and reduction in inflammatory cytokine levels (granulocyte colony-stimulating factor [0.55 (0.05–1.05), p = 0.03], monocyte chemoattractant protein [0.22 (0.01–0.43), p = 0.04], and FMS-like tyrosine kinase-3 ligand [0.91 (−0.01, 1.82), p = 0.053]. Conclusions Perioperative yoga exercise improved QoL, promoted an immune response, and attenuated inflammation in men with prostate cancer. Yoga is feasible in this setting and has benefits that require further investigation. Trial registration clinicaltrials.org (NCT02620033).

show abstract

Section: Discussionmentioning

confidence: 99%

“…Mindfulness defined as "paying attention in a particular way, on purpose, in the present moment, and nonjudgmentally"-has been shown to be improved with yoga practice with focus on breath work [7,8]. Moreover, in addition to improving fitness, flexibility, and muscle tone, yoga lessens anxiety and stress [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial

Kaushik

Shah²,

Mukherjee³

et al. 2021

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…Mistletoe extracts can be recommended within cancer care to treat CRF as an alternative or add-on therapy to physical activity. Mistletoe extracts have a pooled effect estimate that is comparable to other CRF interventions such as physical activity (SMD = -0.30 (95% CI -0.25 to -0.36)) [58], Tai Chi and Qigong (SMD = -0.53 (95% CI -0.97 to -0.28)) [59], and yoga (SMD = -0.30 (95% CI -0.51 to -0.08)) [60]. Patients would therefore have no disadvantage by choosing mistletoe extracts in addition to or instead of the aforementioned therapies, especially those who can no longer perform physical activities.…”

Section: Discussionmentioning

confidence: 52%

Cancer-related fatigue in patients treated with mistletoe extracts: a systematic review and meta-analysis

Pelzer

Loef

Martin

et al. 2022

Support Care Cancer

View full text Add to dashboard Cite

Purpose Cancer-related fatigue remains one of the most prevalent and distressing symptoms experienced by cancer patients. Effective treatments for cancer-related fatigue are needed. The objective of this meta-analysis is to determine the impact of mistletoe extracts as a pharmacological treatment for the management of cancer-related fatigue. Methods We included randomized clinical trials (RCTs) and non-randomized studies of interventions (NRSIs) in cancer patients. Inclusion criteria were cancer-related fatigue severity or prevalence as an outcome and testing of mistletoe extracts compared to control groups. We searched Medline (EuropePMC), Embase, the Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and opengrey.org through October 2020. We assessed the risk of bias using the Cochrane risk of bias tools for RCTs and NRSIs and conducted a meta-analysis. Results We performed one meta-analysis with 12 RCTs, including 1494 participants, and one meta-analysis with seven retrospective NRSIs, including 2668 participants. Heterogeneity between the studies was high in both meta-analyses. Most studies had a high risk of bias. A random-effects model showed for RCTs a standardized mean difference of –0.48 (95% confidence interval –0.82 to –0.14; p = 0.006) and for NRSIs an odds ratio of 0.36 (95% confidence interval 0.20 to 0.66; p = 0.0008). Conclusion Treatment with mistletoe extracts shows a moderate effect on cancer-related fatigue of similar size to physical activity. These results need to be confirmed by more placebo-controlled trials. Future trials should investigate different treatment durations and their effect on cancer-related fatigue in post-treatment cancer survivors. Trial registration. This meta-analysis has been registered under the PROSPERO registration number CRD42020191967 on October 7, 2020.

show abstract

“…Sixteen reviews [23,24,[36][37][38][39][40][41][42][43][44][45][46][47][48][49] explored the effects of exercise therapy on CRF by including studies with different types of exercise, including aerobic exercise, yoga, resistance exercise, and Pilates. For the other 13 reviews, six [50][51][52][53][54][55] focused on yoga, ve[56-60] on aerobic exercise, and two[61, 62] on tai chi. Routine methods of care and/or health education without any active exercise components were commonly utilized as the study comparisons.…”

Section: Characteristics Of the Included Reviewsmentioning

confidence: 99%

“…The other reasons were an unclear description of the blinding procedures [36,40,50,52,53,55,61,62] (n = 8), inclusion of invalid values (RR = 1.0) within the con dence intervals [23,42,49,51,52,59,60,62] (n = 8), failure to report publication bias [38,42,48,49,51,62] (n = 6), unsatisfactory methodological quality of the included RCTs [24,43,44,52,53] (n = 5), unreported or incomplete report of outcomes such as adverse reactions[58] (n = 1), and the inclusion of only one RCT resulting in an inability to measure heterogeneity [42] (n = 1). The results of the evidence assessment are presented in Table 3.…”

Section: Evidence Qualitymentioning

confidence: 99%

Effects of exercise interventions on cancer-related fatigue in breast cancer patients: An overview of systematic reviews

Zhou

Wang

Xu³

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective This overview of systematic reviews (OoSRs) aims to critically appraise and consolidate evidence from current systematic reviews (SRs)/meta-analyses on the effects of exercise interventions on cancer-related fatigue (CRF) in breast cancer patients. Methods SRs/meta-analyses that focused on exercise intervention for CRF in breast cancer and relevant grey literature were searched in electronic databases, through September 2021. Methodological quality of the included SRs was appraised using A MeaSurement Tool to Assess systematic Reviews II (AMSTAR II). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to calculate the grading of outcomes in the included SRs. Stata 16.0 software was utilized for data analysis.Results Twenty-nine reviews were located. The overall methodological quality was unsatisfactory, with only three reviews rated as high quality. The evidence quality was generally low, with no high-quality SRs identified via the GRADE. Moderate certainty evidence indicating exercise could improve fatigue in breast cancer patients (SMD=-0.40 [95%CI -0.58, -0.22]; P=0.0001). Subgroup analysis based on the types of exercise showed that yoga (SMD=-0.30 [95%CI -0.56, -0.05]; I2=28.7%) and aerobic exercise (SMD=-0.29 [95%CI -0.56, -0.02]; I2=16%) had a significantly better effect on CRF in breast cancer patients; exercising for over six months (SMD=-0.88 [95%CI -1.59, -0.17]; I²=42.7%; P=0.0001), three times per week (SMD= -0.77 [95%CI -1.04, -0.05]; I²= 0%; P=0.0001), and for 30 to 60 minutes per session (SMD=-0.81 [95%CI -1.15, -0.47];I²=42.3%; P=0.0001) can contribute to a moderate improvement of CRF. Supervised exercise (SMD=-0.48 [95%CI -0.77, -0.18]; I²=87%; P=0.001) was shown to relieve CRF.Conclusion Exercise played a favorable role in alleviating CRF in breast cancer. Yoga was recommended as a promising exercise for CRF management in majority of the included studies. Exercising for at least three times per week with 30 to 60 minutes per session could be recommended as a suitable dosage for achieving improvement in CRF. Supervised exercise was found to be more effective in alleviating CRF than unsupervised exercise. More rigorously designed clinical studies are warranted to generate more robust evidence to support the use of exercise interventions for CRF management in breast cancer patients.PROSPERO registration of the study protocol: CRD42020219866

show abstract

The Effect of Yoga Interventions on Cancer-Related Fatigue and Quality of Life for Women with Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 43 publications

References 63 publications

Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial

Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial

Cancer-related fatigue in patients treated with mistletoe extracts: a systematic review and meta-analysis

Effects of exercise interventions on cancer-related fatigue in breast cancer patients: An overview of systematic reviews

Contact Info

Product

Resources

About