The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis

Jafari, Fatemeh; Mohammadi, Hamed; Amani, Reza

doi:10.1016/j.jtemb.2021.126753

Cited by 11 publications

(8 citation statements)

References 103 publications

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“…Besides, zinc supplementations were associated with a higher concentration of insulin-like growth factors-1 (IGF-1) (WMD: 8.62 ng/ml, 95% CI: 1.13, 16.11) in children and adults ( 46 ), while not for brain-derived neurotrophic factor levels (SMD: 0.30 μg/ml, 95% CI: −0.08, 0.67) ( 47 ) as well as leptin levels (WMD: 0.74 ng/ml, 95% CI: −1.39, 2.87) ( 48 ) in adults.…”

Section: Resultsmentioning

confidence: 99%

“…The risk of depression was found lower with zinc supplementations (RR: 0.66, 95% CI: 0.50, 0.82), when the depressive symptom scores would be simultaneously lower than those in the control group only if given zinc monotherapy (WMD: −4.15 point, 95% CI: −6.56, −1.75) ( 55 ). However, due to the small magnitude of a meta-analysis, Jafari et al found out that adults taking supplementary zinc for 12 weeks failed to experience elevated blood brain-derived neurotrophic factor concentration (ES: 0.30 ng/ml, 95% CI: −0.08, 0.67) ( 47 ). Apart from derivative diseases, we can also firmly believe that mental and motor development are strengthened by zinc supplementations.…”

Section: Discussionmentioning

confidence: 99%

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Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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It is widely accepted that the zinc element is crucial in human beings. Zinc has gained more attention during the COVID-19 pandemic due to its utilization for the treatment and prevention of respiratory tract infections. However, some studies also pointed out that zinc intake might cause unwanted side effects and even be dangerous when overdosed. To reveal the relationship between zinc intake and health outcomes, we performed an umbrella review from human studies. In total, the umbrella review included 43 articles and identified 11 outcomes for dietary zinc intake and 86 outcomes for supplementary zinc intake. Dietary zinc intake in the highest dose would decrease the risk of overall and specific digestive tract cancers, depression, and type 2 diabetes mellitus (T2DM) in adults. Supplementary zinc consumption in adults was linked to an improvement of depression, antioxidant capacity and sperm quality, higher serum zinc concentration, and lower concentration of inflammatory markers. Zinc supplementation in children would reduce the incidence of diarrhea and pneumonia, improve zinc deficiency and boost growth. However, zinc might not decrease all-cause mortality in adults or the in-hospital mortality of COVID-19. And better maternal and neonatal outcomes may not derive from pregnant women who consumed higher or lower doses of zinc supplementation (>20 mg/day and <20 mg/day, respectively). Dose-response analyses revealed that a daily 5 mg increment of zinc would lower the risk of colorectal and esophageal cancer, whereas a large dose of zinc supplementation (daily 100 mg) showed no benefit in reducing prostate cancer risk.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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“…On the other hand, Zn supplementation in obese individuals increased the serum concentration of BDNF [ 116 ]. However, studies in humans have a limitation due to the circulating BDNF not necessarily reflecting its availability and concentration in encephalic structures [ 117 , 118 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis

et al. 2022

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Zinc (Zn) plays an important role in metabolic homeostasis and may modulate neurological impairment related to obesity. The present study aimed to evaluate the effect of Zn supplementation on the intestinal microbiota, fatty acid profile, and neurofunctional parameters in obese male Wistar rats. Rats were fed a cafeteria diet (CAF), composed of ultra-processed and highly caloric and palatable foods, for 20 weeks to induce obesity. From week 16, Zn supplementation was started (10 mg/kg/day). At the end of the experiment, we evaluated the colon morphology, composition of gut microbiota, intestinal fatty acids, integrity of the intestinal barrier and blood–brain barrier (BBB), and neuroplasticity markers in the cerebral cortex and hippocampus. Obese rats showed dysbiosis, morphological changes, short-chain fatty acid (SCFA) reduction, and increased saturated fatty acids in the colon. BBB may also be compromised in CAF-fed animals, as claudin-5 expression is reduced in the cerebral cortex. In addition, synaptophysin was decreased in the hippocampus, which may affect synaptic function. Our findings showed that Zn could not protect obese animals from intestinal dysbiosis. However, an increase in acetate levels was observed, which suggests a partial beneficial effect of Zn. Thus, Zn supplementation may not be sufficient to protect from obesity-related dysfunctions.

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“…With the increase of temperature, the DTG curve showed two peaks, and the inflection points of the peaks were 85.8 °C and 311.8 °C respectively. In addition, with the increase of temperature, the DTA curve of amomum had a wide exothermic peak, the peak values were 103. trace elements (Jafari et al, 2021;Zhang et al, 2021), including Al, Ba, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, Sc, Se, Sr and Zn, were obtained, as shown in Table 9. According to Table 9, the cumulative contribution rates of the first 4 main factors reached 100.00%, and the eigenvalues of the first 4 main correlation coefficient factors (λ > 0.6) were larger; The first 4 main factors contributed the most to the explanatory variables.…”

Section: ) Thermo Gravimetric Analysis Of Amomummentioning

confidence: 99%

Entropy analysis and grey correlation coefficient cluster analysis of multiple indexes of 5 kinds of condiments

et al. 2022

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Five condiments, including cinnamon, tangerine peel, clove, licorice, amomum, were selected as the research objects in Guangxi, China. The combustion heat, differential thermal gravimetric analysis, fat, crude fiber, trace element, calcium and ash content data for 5 condiments were determined. According to the combustion heat, differential thermal gravimetric analysis, fat, crude fiber, trace element, calcium and ash content data of condiments, we constructed a systematic multi-index comprehensive evaluation system using entropy analysis, gray pattern recognition and grey correlation coefficient cluster analysis. The multi-index comprehensive evaluation system established by the research provides a new idea for the nutritional evaluation of condiments. This research provides a strong scientific basis for the large-scale development of condiment resources and condiment classification research, basic support for the selection of condiment raw materials.

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The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis

Cited by 11 publications

References 103 publications

Zinc Intakes and Health Outcomes: An Umbrella Review

Zinc Intakes and Health Outcomes: An Umbrella Review

Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis

Entropy analysis and grey correlation coefficient cluster analysis of multiple indexes of 5 kinds of condiments

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