The Effect of Zingiber Officinale (Ginger) Root Ethanolic Extract on the Semen Characteristics of Adult Male Wistar Rats

Donkor, Yaw Otchere; Abaidoo, Chrissie Stansie; Tetteh, Joshua; Darko, Nancy Darkoa; Atuahene, Obed Ohene-Djan; Appiah, Atta Kusi; Diby, Thomas; Maalman, Raymond Saa Eru

doi:10.16965/ijar.2018.245

Cited by 7 publications

(6 citation statements)

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“…In accordance with improvement in semen quality by GIN treatment, Khaki et al (2009) reported increased sperm viability and motility in rat treated with GIN for 20 consequence days. In male albino rats, Donkor et al (2018) observed significant increase in sperm count, motility, viability and morphology by administration of ethanolic GIN extract for 30 consecutive days It is reported administration of 100 mg/kg of GIN increased motility, viability, and serum testosterones in rat (Khaki et al 2009). Also, GIN increased sperm motility via protective effect as antioxidant (Amr and Hamza et al 2006).…”

Section: Discussionmentioning

confidence: 97%

Ginger Extract as a Promoter of Sub-Fertility in Buffalo Bulls

Sakr

Ibrahim

Awady

2020

Journal of Animal and Poultry Production

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This study aimed to evaluate the effect of ginger extract (GIN) on reproductive performance of buffalo bulls. Sub-fertile buffalo bulls (n=8) with body weight ranging from 400-450 kg and 22-25 mo of age were divided into two groups (n=4 in each). The 1 st group was fed on the basal diet without treatment, but the basal diet was spread with 10 ml distilled water and served as a control. Bulls in the 2 nd group were fed the basal diet spread with liquid GIN extract (200 mg GIN dissolved in 100 ml/kg diet) for 4 mo (2 mo as a preliminary period and 2 mo as a collection semen period. Semen was collected twice/week for 8 weeks. Blood samples were taken at the end of experiment. Results showed that GIN improved ejaculate volume, motility types, vitality, membrane integrity, concentration and total sperm output, while decreased (P<0.001) reaction time, and acrosomal damage. Also, GIN increased (P<0.001) testosterone by 103.7%, RBCs, PCV, and hemoglobin, while decreased WBCs count (P<0.01). Plasma concentration of total proteins, albumin, globulin significantly increased, while urea and creatinine decreased (P<0.001). Enzyme activity of AST and ALT significantly decreased in GIN group. Oral dose of 200 mg ginger in 100 ml distilled water/kg diet improved sexual activity and semen quality of buffalo bulls with low reproductive efficiency.

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Section: Discussionmentioning

confidence: 97%

Ginger Extract as a Promoter of Sub-Fertility in Buffalo Bulls

Sakr

Ibrahim

Awady

2020

Journal of Animal and Poultry Production

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“…Notable effects include anti-diabetic [ 39 , 40 , 41 ], anti-emetic [ 42 , 43 , 44 ], anti-nauseant [ 45 , 46 ], anti-obesity [ 47 , 48 , 49 , 50 , 51 ], anti-inflammatory [ 52 , 53 , 54 , 55 ], antioxidant [ 56 , 57 , 58 , 59 , 60 ], nephroprotective [ 61 , 62 , 63 ], neuroprotective [ 64 , 65 , 66 ], gastroprotective [ 67 , 68 ], and anti-melanogenesis [ 69 , 70 ] effects. Moreover, ginger may also be protective against male infertility [ 71 ]. The anti-inflammatory and antioxidant activities of ginger extract, and 6-gingerol in particular, have also been shown to have antiproliferative and anticancer properties in another review by de Lima et al [ 26 ].…”

Section: Ginger As a Functional Foodmentioning

confidence: 99%

Polyphenol-Rich Ginger (Zingiber officinale) for Iron Deficiency Anaemia and Other Clinical Entities Associated with Altered Iron Metabolism

Ooi

Pak

Campbell³

et al. 2022

Molecules

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Ginger (Zingiber officinale) is rich in natural polyphenols and may potentially complement oral iron therapy in treating and preventing iron deficiency anaemia (IDA). This narrative review explores the benefits of ginger for IDA and other clinical entities associated with altered iron metabolism. Through in vivo, in vitro, and limited human studies, ginger supplementation was shown to enhance iron absorption and thus increase oral iron therapy’s efficacy. It also reduces oxidative stress and inflammation and thus protects against excess free iron. Ginger’s bioactive polyphenols are prebiotics to the gut microbiota, promoting gut health and reducing the unwanted side effects of iron tablets. Moreover, ginger polyphenols can enhance the effectiveness of erythropoiesis. In the case of iron overload due to comorbidities from chronic inflammatory disorders, ginger can potentially reverse the adverse impacts and restore iron balance. Ginger can also be used to synthesise nanoparticles sustainably to develop newer and more effective oral iron products and functional ingredients for IDA treatment and prevention. Further research is still needed to explore the applications of ginger polyphenols in iron balance and anaemic conditions. Specifically, long-term, well-designed, controlled trials are required to validate the effectiveness of ginger as an adjuvant treatment for IDA.

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“…The study by Donkor et al (2018) evaluated the efficacy of ethanolic ginger extract on the semen parameters. Treatment with ginger extract (100 mg/kg, 300 mg/kg, and 500 mg/kg) for 30 days enhanced sperm count, sperm morphology, sperm viability, and sperm motility.…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

“…Treatment with ginger extract (100 mg/kg, 300 mg/kg, and 500 mg/kg) for 30 days enhanced sperm count, sperm morphology, sperm viability, and sperm motility. The study concluded that could be used in the treatment of male infertility (Donkor et al, 2018). Muhammad et al (2019) assessed the effect of ginger (100 mg/kg/day) on reproductive dysfunction in STZ diabetesinduced rats.…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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The Effect of Zingiber Officinale (Ginger) Root Ethanolic Extract on the Semen Characteristics of Adult Male Wistar Rats

Cited by 7 publications

References 0 publications

Ginger Extract as a Promoter of Sub-Fertility in Buffalo Bulls

Ginger Extract as a Promoter of Sub-Fertility in Buffalo Bulls

Polyphenol-Rich Ginger (Zingiber officinale) for Iron Deficiency Anaemia and Other Clinical Entities Associated with Altered Iron Metabolism

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

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