The effect of α-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites

Takenaka, Yukinori; Miki, Masayuki; Yasuda, Hiroshi; Mino, Makoto

doi:10.1016/0003-9861(91)90370-x

Cited by 125 publications

(46 citation statements)

References 32 publications

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“…Vitamin E is also an important radical scavenging antioxidant that interrupts the chain reaction of lipid peroxidation by reacting with lipid peroxyradicals (Takenaka et al, 1991). The observed increase in plasma ceruloplasmin and vitamin E in diabetic rats may be due to increased lipid peroxides, which is responsible for the increased production of these nonenzymatic antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

Senthilkumar

Subramanian

2007

Pharmaceutical Biology

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Oxidative stress is believed to be a pathogenic factor in the development of diabetic complications. Recently, we have reported the antidiabetic activity of Terminalia chebula Retz. (Combretaceae) fruits on streptozotocin (STZ)-induced experimental diabetes. The current study was aimed to evaluate the antioxidant potential of Terminalia chebula fruits on STZ-induced diabetic rats. Oral administration of ethanol extract of Terminalia chebula fruit at a concentration of 200 mg=kg body weight for 30 days significantly controlled the alteration in the levels of thiobarbituric acid reactive substances, hydroperoxides, and both enzymatic and nonenzymatic antioxidants. In addition, the treatment also resulted in a significant decrease in the levels of blood glucose and glycosylated hemoglobin. The results are comparable with glibenclamide, a known hypoglycemic drug. The presence of biologically active ingredients in the fruit extract may be responsible for the antioxidant properties of the Terminalia chebula fruits, which in turn may be partially responsible for its antidiabetogenic properties.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

Senthilkumar

Subramanian

2007

Pharmaceutical Biology

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“…As a consequence of the activity of ROS, lipid peroxidation can occur. The polyunsaturated fatty acids in the cell membrane are protected against lipid peroxidation through endogenous antioxidants such as the lipid-soluble chain-breaking antioxidant (a-tocopherol) [3,4]. ~-Tocopherol terminates the chain reaction of lipid peroxidation by scavenging lipidperoxyl radicals (LOO') by a process of hydrogen donation.…”

Section: Introductionmentioning

confidence: 99%

The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidant

et al. 1995

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The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble a-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to ot-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in a-tocopherol. Introducing propofol (2 and 5 tiM) restored the protective effect of GSH. Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes. These results suggest that propofol acts similarly to a-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

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“…A link between decreasing vitamin E concentration and lipid peroxidation has been implied in the work of Takenaka et al (1991).…”

Section: Antioxidant Statusmentioning

confidence: 99%

Effect of an Acute Iron Overdose on PMN Cells Chemiluminescence and Indices of Inner Environment in a Swine Model

et al. 2006

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The objective of the study was to evaluate the effect of an acute iron dextran administration on polymorphonuclear cells chemiluminescence and indices of inner environment in piglets. Piglets in the experimental group (n = 16) were given 2000 mg (20 ml) Fe 3+ in the form of iron dextran i.m. Piglets in the control group (n = 13) were given the same amount of physiological saline. Blood was taken before administration, and 1, 4 and 24 hours after. Iron application resulted in a ten times higher concentration of iron in blood plasma in the experimental group. No differences in spontaneous, PMA-and OZP-stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of a muscle injury at the injection site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration. Iron dextran, reactive oxygen species, antioxidant

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The effect of α-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites

Cited by 125 publications

References 32 publications

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidant

Effect of an Acute Iron Overdose on PMN Cells Chemiluminescence and Indices of Inner Environment in a Swine Model

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