The effect of β-cyclodextrin on tenoxicam photostability, studied by a new liquid chromatography method; the dependence on drug dimerisation

Voulgari, Afrodite; Benaki, Dimitra; Michaleas, Sotiris; Antoniadou-Vyza, Ekaterini

doi:10.1007/s10847-006-9206-y

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Inclusion complex between the drug Tenoxican and CD was also characterized by ROESY-2D experiment (Voulgari et al, 2007) and drug molecular dimerization was studied by NOESY, showing that further description of these systems can be obtained with different NMR different experiment.…”

Section: The Noe Experiments For Structural Characterization Of Cds Imentioning

confidence: 99%

Review: Cyclodextrin Inclusion Complexes Probed by NMR Techniques

Pessine¹,

Calderini²,

Alexandrino³

2012

Magnetic Resonance Spectroscopy

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Section: The Noe Experiments For Structural Characterization Of Cds Imentioning

confidence: 99%

Review: Cyclodextrin Inclusion Complexes Probed by NMR Techniques

Pessine¹,

Calderini²,

Alexandrino³

2012

Magnetic Resonance Spectroscopy

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“…The inclusion of small molecules in the CD cavity induces modification of the physicochemical properties of the “guest” molecules, particularly in terms of water solubility and solution stability. , Besides, other properties of an encapsulated molecule are modified by interaction with CDs: photostability, suppression of the bitterness, reduction of the irritating character, etc. One important aspect is to know optimized CD-containing drug formulations, since a less optimum drug bioavailability can result due too much or too little CD.…”

Section: Introductionmentioning

confidence: 99%

Study of the Interaction between Progesterone and β-Cyclodextrin by Electrochemical Techniques and Steered Molecular Dynamics

et al. 2008

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The interaction of progesterone with beta-cyclodextrin (beta-CD) was studied by differential pulse polarography. The aim of the present work was to study the effect of beta-CD on the electrochemical behavior of progesterone in aqueous solution and also to analyze the molecular interactions involved in formation of the inclusion complex. The complex with stoichiometry of 1:1 was thermodynamically characterized. In addition, steered molecular dynamics (SMD) was used to investigate the energetic properties of formation of the inclusion complex along four different pathways (reaction coordinates), considering two possible orientations. From multiple trajectories along these pathways, the potentials of mean force for formation of the beta-CD progesterone inclusion complex were calculated. The energy analysis was in good agreement with the experimental results. In the beta-CD progesterone inclusion complex, a large portion of the steroid skeleton is included in the beta-CD cavity. The lowest energy was found when the D-ring of the guest molecule is located near the secondary hydroxyls of the beta-CD cavity. In the most probable orientation, one intermolecular hydrogen bond is formed between the O of the C-20 keto group of the progesterone and a secondary hydroxyl of the beta-CD.

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“…The effect of cyclodextrins on drug stability is influenced by drug concentration and/or the formation of inclusion complexes of a different nature . Molecular modelling was carried out for βLAP‐RMβCD inclusion complexes to predict possible conformations for 1 : 1 and 1 : 2 stoichiometries.…”

Section: Resultsmentioning

confidence: 99%