The Effect of β-Hydroxy β-Methylbutyrate on Muscular Strength and Body Composition in Collegiate Football Players

Ransone, Jack; NEIGHBORS, KERRI; LeFavi, Robert G.; Chromiak, Joseph A.

doi:10.1519/00124278-200302000-00006

Cited by 27 publications

(37 citation statements)

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“…However, despite some support for the efficacy of HMB in conditions of increased loading, positive adaptations have not always been evident. Similar improvements in lean tissue between RT vs. HMB + RT groups have been reported in studies of comparable HMB dosage and RT frequency/duration (Jowko et al, 2001;Kreider et al, 1999;Ransone et al, 2003;Vukovich et al, 2001). Thus, the collective body of work addressing the ergogenic effect of HMB on loaded skeletal muscle appears equivocal at best.…”

Section: Discussionsupporting

confidence: 75%

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Kim

Park

Lee

et al. 2012

Molecules and Cells

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Older women exhibit blunted skeletal muscle hypertrophy following resistance training (RT) compared to other age and gender cohorts that is partially due to an impaired regenerative capacity. In the present study, we examined whether β-hydroxy-β-methylbutyrate (HMB) provision to aged female rodents would enhance regenerative mechanisms and facilitate RT-induced myofiber growth. Nineteen-month old female Sprague-Dawley rats were randomly divided into three groups: HMB (0.48 g/kg/d; n = 6), non-HMB (n = 6), and control (n = 4). HMB and non-HMB groups underwent RT every third day for 10 weeks using a ladder climbing apparatus. Whole body strength, grip strength, and body composition was evaluated before and after RT. The gastrocnemius and soleus muscles were analyzed using magnetic resonance diffusion tensor imaging, RT-PCR, and immunohistochemistry to determine myofiber dimensions, transcript expression, and satellite cells/myonuclei, respectively. ANOVAs were used with significance set at p < 0.05. There were significant time effects (pre vs. post) for whole body strength (+262%), grip strength (+17%), lean mass (+20%), and fat mass (-19%). Both RT groups exhibited significant increases in the mean myofiber cross-sectional area (CSA) in the gastrocnemius and soleus (+8-22%) compared to control. Moreover, both groups demonstrated significant increases in the numbers of satellite cells (+100-108%) and myonuclei (+32%) in the soleus but not the gastrocnemius. A significant IGF-I mRNA elevation was only observed in soleus of the HMB group (+33%) whereas MGF and myogenin increased significantly in both groups (+32-40%). Our findings suggest that HMB did not further enhance intense RT-mediated myogenic mechanisms and myofiber CSA in aged female rats.

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Section: Discussionsupporting

confidence: 75%

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Kim

Park

Lee

et al. 2012

Molecules and Cells

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“…These results repeated in Thomson et al 22 study in trained men after 9 weeks resistance training. But these findings are not supported by several investigations 8,9,16,24,27,28 .…”

Section: Discussioncontrasting

confidence: 71%

“…It has been suggested that the HMB effect on body composition is inconsequential 23 .Some studies reported that HMB was unable to change the body composition of athletes involved in resistance training (22), water polo, rowing 9 or football 17,24 .On the other hand, a number of studies failed to confirm these results and indicated that HMB supplementation during 2-to 12-weeks of training promoted significantly greater changes in FFM and fat loss in trained and untrained men and women 4,5,25,26 . Based on previous studies, the data about the effect of HMB supplementation on body composition is inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Arazi

Rohani²,

Ghiasi

et al. 2015

Rev Bras Med Esporte

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RESUMOIntroduction: In recent years, there was an increased interest on the effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on skeletal muscle due to its anti-catabolic effects. Objectives: To investigate the effect of HMB supplementation on body composition, muscular strength and anabolic-catabolic hormones after resistance training. Methods: Twenty amateur male athletes were randomly assigned to supplement and control groups in a double-blind crossover design and participated in four weeks resistance training. Before and after the test period fasting blood samples were obtained to determine anabolic (the growth hormone and testosterone) and catabolic (cortisol) hormones, and fat mass, lean body mass (LBM) and muscular strength were measured. Dependent and independent t-tests were used to analyze data. Results: After the training period, there were no significant differences between the groups with respect to fat mass, LBM and anabolic-catabolic hormones. HMB supplementation resulted in a significantly greater strength gain (p≤0.05). Conclusion: Greater increase in strength for HMB group was not accompanied by body composition and basal circulating anabolic-catabolic hormonal changes. It seems that HMB supplementation may have beneficial effects on neurological adaptations of strength gain.Keywords: resistance training, hormones, body composition, dietary supplements, HMB, muscle strength. ABSTRACT Introduçao: Nos últimos anos, houve um aumento no interesse sobre os efeitos da suplementação de beta-hidroxi--beta-metilbutirato (HMB) no

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“…Ransone et al 31 conduziram um estudo randomizado e duplo-cego de quatro semanas de duração com jogadores de futebol americano. Cada sujeito participou de sessões de treinamento contra-resistência quatro vezes na semana, executando 10 exercícios com 8-12 séries de 2-10 repetições por exercício a 70%-90% de 1 RM por sessão.…”

Section: Efeitos Do Hmb Em Indivíduos Treinados Em Atividade Contra-runclassified

“…Panton et al 17 Ransone et al 31 Kreider et al 32 Kreider et al 34 Thomson 35 Kreider et al 37 Hoffman et al 38 39 H e 36 …”

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Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

Álvares

Meirelles

2008

Rev. Nutr.

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Efeitos da suplementação de β-hidroxi-β-metilbutirato sobre a força e a hipertrofia Effects of β-hydroxy-β-methylbutyrate supplementation on strength and hypertrophyThiago da Silveira ALVARES 1 Cláudia de Mello MEIRELLES 1,2,3 R E S U M OO β-hidroxi-β-metilbutirato é um metabólito da leucina estudado devido aos seus efeitos anticatabólicos e possíveis implicações sobre os ganhos de força e massa muscular associados ao treinamento contra--resistência (conhecido como musculação). O objetivo deste trabalho foi revisar a literatura referente à suplementação de β-hidroxi-β-metilbutirato e os seus efeitos sobre força e hipertrofia em adultos jovens e idosos iniciantes ou treinados em treinamento contra-resistência. Estudos em indivíduos iniciando um programa de treinamento contra-resistência sugerem que a suplementação diária de 1,5 a 3,0g de β-hidroxi-β-metilbutirato pode trazer benefício ergogênico durante as primeiras quatro ou cinco semanas. Entretanto, à medida que o programa de treinamento evolui, tais efeitos não permanecem e os ganhos de força e massa muscular são proporcionados apenas pelo treinamento contra-resistência. Em indivíduos treinados, os resultados parecem não ser os mesmos, uma vez que, desde o início da suplementação, o β-hidroxi-β-metilbutirato não demonstra qualquer benefício adicional aos induzidos pelo treinamento contra-resistência. Alguns efeitos do β-hidroxi-β-metilbutirato na redução do colesterol total e lipoproteína de baixa densidade também foram observados, porém, devido às poucas evidências, não há recomendações para tal finalidade. Nenhum efeito adverso da suplementação foi observado, sendo, aparentemente, segura, contudo a maioria dos estudos foi realizada em curto prazo (menos de 4 semanas) e em indivíduos destreinados. Assim, mais estudos são necessários para esclarecer o mecanismo fisiológico por meio do qual o β-hidroxi-β-metilbutirato exerce seus efeitos anticatabólicos em destreinados e para observar possíveis efeitos adversos.

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The Effect of β-Hydroxy β-Methylbutyrate on Muscular Strength and Body Composition in Collegiate Football Players

Cited by 27 publications

References 0 publications

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

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