The effect of β-pyridylcarbinol on lipoprotein lipids in primary type IIa hyperlipoproteinemia

Schwandt, P.; Weisweiler, P.; Neureuther, G.

doi:10.1016/0021-9150(79)90103-5

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…b Log fe'(corr) = log fe'(obsd) + log [(10"pKa + l0"pH)/10"pH]. 6 Data from ref 17. d Negative log of Langmuir's a constant, which is inversely proportional to the effective binding constant.…”

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confidence: 99%

A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships

Brent¹,

Sabatka²,

Minick³

et al. 1983

J. Med. Chem.

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A highly deactivated octadecyl-bonded silica column and a mobile phase consisting of an water-methanol mixture in the range of blood pH and ionic strength are used to correlate log kappa' with biological activity for a series of sulfonamides and barbiturates. The results were compared to literature methods by using retention volume (VR) and retention indexes (I). For the nine sulfonamides tested, log VR and log kappa' were used with and without correction for ionization. For each biological end point (protein binding and minimum inhibitor concentration against Eschericia coli from two sources) and each independent variable (log kappa' and log VR) the residual standard derivation for the regression was determined. the standard derivations were compared in an F test for each of 12 relevant regressions. Log kappa' was statistically superior in for cases, while log VR was superior in one case. Overall, the methods were statistically indistinguishable. Log kappa' values and I values for 15 barbiturates were regressed against three biological end points [hypnotic activity (the minimum effective dose in rabbits), inhibition of Arbacia egg cell division, and inhibition of rat brain respiration]. Standard deviations were compared by an F test, and the two methods were indistinguishable as far as the goodness of biological correlations are concerned. Procedures for controlling the column's activity are presented. Choices for an appropriate mobile phase are discussed, and a method of calculating pH and ionic strength in a methanol-aqueous mobile phase is presented.

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mentioning

confidence: 99%

A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships

Brent¹,

Sabatka²,

Minick³

et al. 1983

J. Med. Chem.

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Drugs controlling triglyceride metabolism

Franceschini

Paoletti

1993

Medicinal Research Reviews

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Wirkung von Bezafibrat bei primären Hyperlipidämien

et al. 1982

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The effect of long-term treatment over 40 weeks with Bezafibrate on lipids and lipoproteins was investigated in 27 patients with primary hyperlipoproteinemias (hlp) (12 patients with hlp type IV, 7 patients with type IIb, 3 patients with type IIa, 4 patients with type V and 1 patient with type III). Bezafibrate reduced total cholesterol by 16%, whereas HDL-cholesterol increased by 28% and 36% (p less than 0.05). Serumtriglycerides decreased by 59% (450 mg Bezafibrate daily) and by 66% (600 mg Bezafibrate daily) statistically significant (p less than 0.05). In hyperlipidemias type IV, IIb, IIa and V increases of HDL-cholesterol could be observed. The course of LDL-cholesterol was different in the various types of hlp. The postheparin-lipoprotein-lipase (PHLA) was activated by treatment with Bezafibrate from 10.5 +/- 0.7 to 14.7 +/- 0.7 and 15.5 +/- 0.8 mumol FFA/ml/h or by 30% (p less than 0.05). Only few side-effects during treatment with Bezafibrate could be ascertained.

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The effect of β-pyridylcarbinol on lipoprotein lipids in primary type IIa hyperlipoproteinemia

Cited by 4 publications

References 14 publications

A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships

A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships

Drugs controlling triglyceride metabolism

Wirkung von Bezafibrat bei primären Hyperlipidämien

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