The effect of Δ1-tetrahydrocannabinol on the uptake of serotonin by rat brain homogenates

Sofia, R. D.; Ertel, Robert J.; Dixit, Balwant N.; Barry, Herbert

doi:10.1016/0014-2999(71)90025-2

Cited by 32 publications

(11 citation statements)

References 10 publications

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“…The hypothermic effect of THC, when injected into cerebral ventricles, suggests that the primary action of this agent is in the CNS (4). According to some authors the hypothermic effect of THC may be related to changes of 5-HT and/or noradrena line metabolism in the brain (9,14), however, this hypothesis has not been confirmed by others (1 ,1 3 , 21).…”

Section: Discussionmentioning

confidence: 67%

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

Uran¹,

Tulunay²,

Ayhan³

et al. 1980

Pharmacology

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The administration of 0.3–40 mg/kg Δ⁹-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed.

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Section: Discussionmentioning

confidence: 67%

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

Uran¹,

Tulunay²,

Ayhan³

et al. 1980

Pharmacology

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“…Holtzman et al (1969) suggested that the hypothermic response in mice induced by A9-THC is correlated to changes in the brain levels of noradrenaline (NA) and 5-HT. Other workers have found that A9-THC or cannabis extracts cause brain NA concentrations to fall (Schildkraut & Efron, 1971), to rise (Constantinidis & Miras, 1971) or to remain unchanged (Maitre, Staehelin & Bein, 1970;Mazurkiewicz-Kwilecki & Filczewski, 1973), whereas concentrations of 5-HT have been reported to increase (Schildkraut & Efron, 1971; Sofia, Dixit & Barry, 1971) or to remain unchanged (Gallager, SandersBush & Sulser, 1972;Yagiela, McCarthy & Gibb, 1974). 0 In the light of these conflicting reports, it was decided to investigate the effect of A9-THC on the body temperature of rats maintained at different 5 ambient temperatures, and at the same time to examine whether a correlation exists between changes in body temperature and changes in brain monoamine concentrations.…”

Section: Introductionmentioning

confidence: 99%

THE EFFECT OF Δ⁹‐TETRA‐HYDROCANNABINOL ON BODY TEMPERATURE AND BRAIN AMINE CONCENTRATIONS IN THE RAT AT DIFFERENT AMBIENT TEMPERATURES

Fennessy

Taylor

1977

British J Pharmacology

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I Rats were injected intravenously with 2 mg/kg (-)-trans-A9-tetrahydrocannabinol (A9-THC) at ambient temperatures of 40, 2 10, 310 and 370C. 2 The general behaviour exhibited by rats treated with A9-THC was similar at all four ambient temperatures.3 Body temperatures were recorded continuously before and after drug administration. At 40 and 210C, A9-THC caused hypothermia whereas no change in body temperature occurred at 310 and 370C. 4 The concentrations in the whole brain of noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined spectrophotofluorimetrically 1 h after drug administration. At 40C A9-THC caused an increase of 5-HT, at 21 OC an increase of 5-HIAA, at 31 OC an increase of 5-HIAA and a decrease of NA, and at 370C an increase of 5-HT and 5-HIAA.5 At all ambient temperatures, A9-THC increased the brain levels of 5-HT and/or 5-HIAA. A correlation between the A9-THC-induced hypothermic response and the possible alteration of brain 5-HT metabolism cannot be excluded.

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“…Since A9-tetrahydrocannabinol (A9-THC) has been shown to alter the brain levels of 5-hydroxytryptamine (5-HT) (Holtzman, Lovell, Jaffe & Freedman, 1969;Schildkraut & Efron, 1971;Sofia, Dixit & Barry, 1971) and 5-hydroxyindoleacetic acid (5-HIAA) it has been suggested that A9-THC may exert some of its effects, such as hypothermia, through modification of tryptaminergic mechanisms. Evidence from previous studies indicates that clomipramine, a tricyclic antidepressant, preferentially inhibits the neuronal uptake of 5-HT (Lidbrink, Jonsson & Fuxe, 1971;Sugrue, Goodlet & Mireylees, 1976).…”

Section: Introductionmentioning

confidence: 99%

ANTAGONISM OF THE EFFECTS ON THERMOREGULATION OF Δ⁹‐TETRAHYDROCANNABINOL BY CLOMIPRAMINE IN THE RAT

Fennessy

Taylor

1978

British J Pharmacology

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1 The effect of pretreatment with clomipramine hydrochloride (15 mg/kg, i.p.) on the (-)-trans-A9-tetrahydrocannabinol (A9-THC)-induced changes in body temperature and brain amines of the rat was investigated. 2 A dose of 0.05 mg/kg of A9-THC produced hyperthermia and a decrease in whole brain concentration of 5-hydroxyindoleacetic acid (5-HIAA). Doses of 2 and 5 mg/kg produced hypothermia and increases in brain 5-HIAA whereas 0.5 mg/kg did not affect either parameter. A9-THC, at any of the doses, did not affect the whole brain concentrations of dopamine, noradrenaline or 5-hydroxytryptamine. 3 Clomipramine modified these responses of A9-THC in that the dose-response curves appeared to be shifted to the right. 4 It is concluded that clomipramine acts as an antagonist to these actions of A9-THC by interfering with entry of A9-THC into tryptaminergic neurones.

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The effect of Δ1-tetrahydrocannabinol on the uptake of serotonin by rat brain homogenates

Cited by 32 publications

References 10 publications

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

THE EFFECT OF Δ⁹‐TETRA‐HYDROCANNABINOL ON BODY TEMPERATURE AND BRAIN AMINE CONCENTRATIONS IN THE RAT AT DIFFERENT AMBIENT TEMPERATURES

ANTAGONISM OF THE EFFECTS ON THERMOREGULATION OF Δ⁹‐TETRAHYDROCANNABINOL BY CLOMIPRAMINE IN THE RAT

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The effect of Δ1-tetrahydrocannabinol on the uptake of serotonin by rat brain homogenates

Cited by 32 publications

References 10 publications

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

Correlation between the Dose and Development of Acute Tolerance to the Hypothermic Effect of THC

THE EFFECT OF Δ9‐TETRA‐HYDROCANNABINOL ON BODY TEMPERATURE AND BRAIN AMINE CONCENTRATIONS IN THE RAT AT DIFFERENT AMBIENT TEMPERATURES

ANTAGONISM OF THE EFFECTS ON THERMOREGULATION OF Δ9‐TETRAHYDROCANNABINOL BY CLOMIPRAMINE IN THE RAT

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THE EFFECT OF Δ⁹‐TETRA‐HYDROCANNABINOL ON BODY TEMPERATURE AND BRAIN AMINE CONCENTRATIONS IN THE RAT AT DIFFERENT AMBIENT TEMPERATURES

ANTAGONISM OF THE EFFECTS ON THERMOREGULATION OF Δ⁹‐TETRAHYDROCANNABINOL BY CLOMIPRAMINE IN THE RAT