The effectiveness and safety of Chinese Patent Medicines based on syndrome differentiation in patients following percutaneous coronary intervention due to acute coronary syndrome (CPM trial): A nationwide Cohort Study

Bai, Ruina; Yang, Qiaoning; Xi, Ruixi; Che, Qianzi; Zhao, Yang; Guo, Ming; Dong, Guoju; Gao, Zhuye; Fu, Changgeng; Wang, Peili; Gu, Feng; Du, Jia; Zhang, Dawu; Duan, Weijia; Liu, Lizhi; Shi, Dazhuo

doi:10.1016/j.phymed.2022.154554

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…The results showed that this kind of syndrome differentiation and treatment reduced the incidence of the 3 main outcomes mentioned previously, improved quality of life, and reduced indicators related to rehospitalization for thrombotic events such as acute coronary syndrome and heart failure. [27] This large RCT validated the scientific validity of the concept of TCM evidence-based treatment and provided a reference for more standardized clinical studies related to evidence-based staging.…”

Section: Clinical Evidence and Mechanisms Of Tcm Against Cardiovascul...mentioning

confidence: 75%

“…) is a formula used for tumor treatment, and it can clear heat, remove toxins, ChiCTR-OOC-14,005,552 [27] Xinkeshu tablets Danshen, Gegen, Shanzha, Sanqi, Muxiang Xinkeshu tablets/placebo, 4#, tid, 12 wk Depressive/anxiety symptoms and the levels of 440 peripheral blood cytokines ChiCTR-IPR-17010940 [103] Danhong injection Danshen, Honghua DHI/0.9% normal saline (40 mL, qd) + 0.9% normal saline (250 mL, ivgtt, qd)…”

Section: Mechanisms 421 Inhibition Of Tumor Cell Proliferation and In...mentioning

confidence: 99%

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Clinical evidence and mechanisms of traditional Chinese medicine in major diseases

Luo,

Li,

Wang

et al. 2023

Sci Tradit Chin Med

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Major diseases cause a double blow to patients' physical and mental health and family life and pose a great challenge to the healthcare system. The high incidence of major diseases compels us to constantly improve the medical prevention and treatment system to reduce disability and death rates as much as possible. Traditional Chinese medicine (TCM) has been widely used in the treatment of malignancies and cardiovascular and cerebrovascular diseases such as myocardial infarction and stroke, in the rehabilitation of patients with these diseases, as well as in the prevention and treatment of new outbreaks of infectious diseases and other major illnesses. After the coronavirus disease 2019 outbreak, the clinical application of “three prescriptions and three drugs” has greatly increased the cure rate, reduced the mortality rate, and provided a “Chinese solution” for global epidemic prevention and control. This article reviewed the clinical evidence and mechanisms of action of TCM in the prevention and treatment of major diseases, summarized the advances, and proposed future research directions to provide scientific evidence to expand the clinical application of TCM and improve its efficacy for the benefit of all humankind.

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Section: Clinical Evidence and Mechanisms Of Tcm Against Cardiovascul...mentioning

confidence: 75%

Section: Mechanisms 421 Inhibition Of Tumor Cell Proliferation and In...mentioning

confidence: 99%

Clinical evidence and mechanisms of traditional Chinese medicine in major diseases

Luo,

Li,

Wang

et al. 2023

Sci Tradit Chin Med

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show abstract

“…While there exists a substantial body of evidence supporting the effectiveness of natural remedies in direct disease treatment, this approach has encountered challenges such as the limited oral bioavailability of certain constituents, a low cellular uptake rate, and the instability of active ingredients over time. [107][108][109] These hurdles constrain the standardized application and exploration of natural pharmaceutical preparations. 110 A promising solution to surmount these issues involves harnessing nanocarriers, including small extracellular vesicles, for the extraction and conveyance of the active elements found in natural medicines.…”

Section: Msc-sev Pretreated With Natural Drugsmentioning

confidence: 99%

A Powerful Tool in the Treatment of Myocardial Ischemia-Reperfusion Injury: Natural and Nanoscale Modified Small Extracellular Vesicles Derived from Mesenchymal Stem Cells

Zhou,

Zhang,

Wang

et al. 2023

IJN

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Myocardial ischemia-reperfusion injury (MI/RI) constitutes a pivotal determinant impacting the long-term prognosis of individuals afflicted by ischemic cardiomyopathy subsequent to reperfusion therapy. Stem cells have garnered extensive application within the realm of MI/RI investigation, yielding tangible outcomes. Stem cell therapy encounters certain challenges in its application owing to the complexities associated with stem cell acquisition, a diminished homing rate, and a brief in vivo lifespan. Small extracellular vesicles (sEV) originating from mesenchymal stem cells (MSCs) have been demonstrated to possess the benefits of abundant availability, reduced immunogenicity, and a diminished tumorigenic incidence. They can exert their effects on damaged organs, improving injuries by transporting a lot of constituents, including proteins, RNA, lipid droplets, and more. This phenomenon has garnered substantial attention in the context of MI/RI treatment. Simultaneously, MSC-derived sEV (MSC-sEV) can exhibit enhanced therapeutic advantages through bioengineering modifications, biomaterial incorporation, and natural drug interventions. Within this discourse, we shall appraise the utilization of MSC-sEV and their derivatives in the context of MI/RI treatment, aiming to offer valuable insights for future research endeavors related to MI/RI.

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“…The distinctive feature of syndrome differentiation in traditional Chinese medicine (TCM) has been extensively utilized in the clinical diagnosis and treatment of various diseases. 1 , 2 , 3 Holistic syndrome differentiation is a unique clinical diagnostic method based on TCM theory, which enables comprehensive analysis of a patient's overall pathological condition to assess the intricacy of TCM syndrome patterns for clinical practice. 4 , 5 , 6 , 7 The TCM holistic syndrome differentiation diagnosis method plays a significant role in the treatment and outcome of various diseases, serving as a crucial component within the distinctive clinical TCM diagnosis and treatment system.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning

Chen,

Zhang,

Liu

et al. 2024

Integrative Medicine Research

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The effectiveness and safety of Chinese Patent Medicines based on syndrome differentiation in patients following percutaneous coronary intervention due to acute coronary syndrome (CPM trial): A nationwide Cohort Study

Cited by 7 publications

References 15 publications

Clinical evidence and mechanisms of traditional Chinese medicine in major diseases

Clinical evidence and mechanisms of traditional Chinese medicine in major diseases

A Powerful Tool in the Treatment of Myocardial Ischemia-Reperfusion Injury: Natural and Nanoscale Modified Small Extracellular Vesicles Derived from Mesenchymal Stem Cells

Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning

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