The effectiveness and safety of acupuncture for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Xu, Zhijun; Wang, Fudi; Wu, Yue; Wang, Chengbing; Fang, Xuedong

doi:10.3389/fneur.2022.963358

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…There are currently 2 systematic reviews 18,27 of neuromodulation interventions and 4 studies [80][81][82][83] of acupuncture for CIPN similar to ours. There are similarities in the results, suggesting that such therapies reduce neuropathic pain 27,83,84 and improve patient quality of life.…”

Section: Comparison Of Similar Studiesmentioning

confidence: 57%

“…There are similarities in the results, suggesting that such therapies reduce neuropathic pain 27 , 83 , 84 and improve patient quality of life. 81 , 83 It can also be combined with usual care to improve outcomes. 82 However, unlike other studies: we found that neuromodulation interventions significantly improved CIPN symptoms (FACT-Ntx and EORTC QLQ-CIPN20) compared with usual care, but there was no significant difference in efficacy compared with sham stimulation across all outcomes.…”

Section: Discussionmentioning

confidence: 99%

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The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Xu,

Yu,

Zhang

et al. 2024

JPR

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To determine the efficacy and safety of a neuromodulation intervention regimen in the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Patients and Methods: Systematic searches were conducted in seven English databases. Randomized controlled trials of all neuromodulation interventions (both invasive and non-invasive) for the treatment of CIPN were selected. Group comparisons of differences between interventions and controls were also made. We divided the outcomes into immediate-term effect (≤3 weeks), short-term effect (3 weeks to ≤3 months), and long-term effect (>3 months). Results: Sixteen studies and 946 patients with CIPN were included. Among immediate-term effects, neuromodulation interventions were superior to usual care for improving pain (SMD=−0.77, 95% CI −1.07~ 0.47), FACT-Ntx (MD = 5.35, 95% CI 2.84~ 7.87), and QOL (SMD = 0.44, 95% CI 0.09~ 0.79) (moderate certainty); neuromodulation loaded with usual care was superior to usual care for improving pain (SMD=−0.47, 95% CI −0.71 ~ −0.23), and QOL (SMD = 0.40, 95% CI 0.12 ~ 0.69) (moderate certainty). There were no statistically significant differences between the neuromodulation interventions regimen vs usual care in short-and long-term outcomes and neuromodulation vs sham stimulation from any outcome measure. There were mild adverse events such as pain at the site of stimulation and bruising, and no serious adverse events were reported. Conclusion: Neuromodulation interventions had significant immediate-term efficacy in CIPN but had not been shown to be superior to sham stimulation; short-term and long-term efficacy could not be determined because there were too few original RCTs. Moreover, there are no serious adverse effects of this therapy.

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Section: Comparison Of Similar Studiesmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Xu,

Yu,

Zhang

et al. 2024

JPR

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“…Furthermore, its effectiveness in improving FC and HRQOL has been verified [20,21]. Despite the limited number of randomized clinical trials examining the safety and efficacy of acupuncture in CKD patients receiving maintenance HD, these parameters have been extensively investigated and established across diverse medical conditions [28][29][30][31][32][33][34]. Nevertheless, the results of a recent review and meta-analysis indicate that acupuncture may be a safe and effective therapeutic alternative for uremic pruritus in patients undergoing HD.…”

Section: Discussionmentioning

confidence: 99%

Integrating Acupuncture into a Dialysis Center

et al. 2023

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A growing interest in integrating traditional Chinese medicine (TCM) and conventional medicine (CM) to create a more comprehensive approach to healthcare has been verified. Scientific evidence supports acupuncture as an integrative treatment for specific health conditions. The aim of this study was to assess the acceptance and feasibility by patients and healthcare professionals of integrating acupuncture in a dialysis center. Individuals undergoing hemodialysis (HD) who participated in a patient-assessor-blinded randomized controlled trial that evaluated the effect of acupuncture on functional capacity and quality of life were included. Acceptance was measured by adherence (percentage of patients who completed treatments and dropouts) and patients’ and healthcare professionals’ opinions toward acupuncture (pre- and pro-intervention questionnaires). Feasibility was measured by safety (number of reported adverse events) and effectiveness (changes in functional capacity, peripheral muscle strength, and health-related quality of life scores after treatment). Forty-eight patients were included, and forty-five (93.8%) were analyzed. No adverse events were reported. All patients completed the treatment, and only three patients (6.2%) were lost to the 12-week post-treatment follow-up. The attitudes of patients and health professionals were favorable to acupuncture, namely in relation to its use, degree of discomfort, recommendation to others, and interference with routine care and clinical setting. Integrating acupuncture into a dialysis center seems viable and well-accepted by patients with kidney failure on maintenance HD, doctors and nurses.

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“…Other treatment alternatives are venlafaxine, pregabalin, amitriptyline, tramadol, strong opioids and topical baclofen (87); although limited evidence and ASCO advices against use outside studies (88). A meta-analysis of acupuncture showed no improvement in CIPN symptoms or impairment, but pain was relieved (151). Treatment decisions should take depression, anxiety, and sleep into consideration due to association with CIPN (121,152).…”

Section: Prevention and Treatment Of Cipnmentioning

confidence: 99%

Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models

Engvall

2024

Linköping University Medical Dissertations

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Background: Taxane-induced peripheral neuropathy (TIPN) is a common and distressful side effect. Little is known on how long TIPN persist and its effect on health-related quality of life (HRQL). The overall aim of this thesis was to study the prevalence and severity of persistent TIPN, to investigate its impact on HRQL and to explore the clinical and genetic risk factors for TIPN among early-stage breast cancer survivors (ESBCS).Methods: A population-based cohort of 884 recurrence-free ESBCS diagnosed 2010-2015 in the Southeast Health Care region, Sweden and 1768 control women without prior cancer, who received a postal questionnaire including EORTC chemotherapy-induced peripheral neuropathy (CIPN20) and QLQ-C30 instruments. Prevalence of TIPN symptoms and clinical risk factors were explored. Adjusted relative risks (RR) were estimated for ESBCS compared to control women. For impact on HRQL, adjusted mean scores of QLQ-C30 scales among ESBCS with and without TIPN were calculated. Blood samples from 362 ESBCS were whole-exome sequenced. We leveraged logistic regression models to develop and validate polygenic prediction models to estimate the risk of persistent PN symptoms in a training and test cohort.Results: The response rate was 79% for ESBCS and 59% for controls. The median time post-taxane was 3.6 years. The adjusted RR for ESBCS vs. controls was highest (RR 1.8) for tingling in feet and numbness in feet. Individual sensory symptoms occurred in 9%-48% and motor symptoms in 7%-61% of ESBCS. The most prevalent symptoms were difficulty opening jar and cramps in feet. Paclitaxel, older age, overweight, diabetes mellitus, vibrating hand tools, smoking and autoimmune disease were independent risk factors (Study I). All 13 sensory and motor TIPN symptoms at increased risks among ESBCS had a significant impact on global health status, which worsened with increased severity of TIPN. Between 30%-93% of ESBCS with moderate-severe TIPN reported a clinically important impairment of functioning and personal finances. Moderate-severe difficulty climbing stairs and problems standing/walking were associated with medium-large clinically important differences (Study II). In the explorative sub-study, two of five prediction models based on genetic and clinical risk factors obtained Did you have difficulty hearing?Difficulty hearingPlease answer the following question only if you drive a car Did you have difficulty using the pedals? Difficulty using pedals Docetaxel60+Capecitabin900 2 w x 3-4 Concomitant with EC-T 3w, every 3 weeks; 2w, every 2 weeks; EC, Epirubicin-Cyclophosphamide. Note: As suggested in revision of guidelines.Neoadjuvant chemotherapy is the preferred choice in HER2+ and TNBC due to highly proliferative disease, the possibility to evaluate response (26), and since the evidence as to the efficacy of additional treatments is only shown in trials conducted in a neoadjuvant setting. In HER2+ disease, 'Plus' Increase of sensation Tingling, Burning sensation Allodynia, Hyperalgesia Cramps 'Minus' Loss of function Num...

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The effectiveness and safety of acupuncture for chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Cited by 10 publications

References 43 publications

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Integrating Acupuncture into a Dialysis Center

Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models

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