The effectiveness and safety of nonsurgical integrative interventions for symptomatic lumbar spinal spondylolisthesis

Abstract

Background:Surgery is generally accepted as the main therapeutic option for symptomatic lumbar spondylolisthesis. However, new nonsurgical therapeutic options need to be explored for this population.Objectives:The objective of this study is to assess the effectiveness and safety of a 5-week Mokhuri treatment program compared with conventional nonsurgical treatments for symptomatic lumbar spondylolisthesis.Methods:This is a study protocol for a multinational, multicenter clinical randomized controlled trial comparing the effectiveness and safety of 5 weeks of nonsurgical integrative treatments (a Mokhuri treatment program consisting of Chuna, acupuncture, and patient education) with nonsurgical conventional treatments (drugs for pain relief, epidural steroid injections, and physical therapy). Clinical outcomes including visual analogue scale (VAS) scores ranging from 0 to 100 for low back pain and leg pain, EQ-5D scores, Oswestry disability index (ODI) scores, Roland–Morris Disability Questionnaire (RMDQ) scores, Zurich Claudication Questionnaire (ZCQ) scores, walking duration and distance without leg pain, and a 5-minute treadmill test, and the ratio between the actual duration of participation and the originally scheduled duration in each group, the presence of any additional spondylolisthesis treatments, the types of concomitant treatments during the follow-up period, and adverse events (AEs) will be assessed at 7 weeks, 18 weeks, 30 weeks, 54 weeks, and 102 weeks after the end of the treatments.Conclusion and discussion:The results of this study will provide clinical evidence on nonsurgical integrative interventions for patients with symptomatic lumbar spondylolisthesis.Clinical trial registry:clinicaltrials.gov (NCT03107468)

A Protocol for a Single-Centered, Pragmatic, Randomized, Controlled, Parallel Trial Comparing Comprehensive Nonsurgical Therapy Options for Individuals with Lumbar Spinal Stenosis

“…12 The multimodal integrative treatments without herbal concoctions versus conventional nonsurgical therapies have been protocolized for symptomatic lumbar spinal spondylolisthesis. 41 Lumbar Acupotomy is helpful for soft tissue pathologies, including weakened muscles, ligaments, and articular capsules. 42 Recent studies suggest that acupotomy may be an effective non-invasive treatment for LSS in a meta-analysis of pooled estimates.…”

Research trends of acupuncture therapy on stress urinary incontinence from 1992 to 2022: A bibliometric analysis

“…While Chinese institutions did not publish their first article until 2008. Since the relevant research had just surged in the recent decade in China, and Chinese institutions led the way in the number of publications, it is recommended that Chinese institutions should pave the way for multinational projects, as in other fields of acupuncture treatment [ 23 , 24 ].…”

Phase angle is related to physical function and quality of life in preoperative patients with lumbar spinal stenosis

“…The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) is a patient-administered scale that includes a lumbar spine disease-specific QOL assessment that can evaluate not only pain but also functional disability, gait dysfunction, social disadvantage, and psychological disability due to back pain [3]. The EuroQOL 5 dimensions 3-level (EQ-5D) is a scale that assesses a comprehensive health-related quality of life score that evaluates mobility, self-care, activity, pain, and depression on three levels [4].…”