The effectiveness of 0.5–0.7% tetracycline gel to reduced subgingival plaque bacteria

Setiawati, Ernie Maduratna

doi:10.20473/j.djmkg.v41.i3.p114-117

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Tetracycline further exerts direct inhibitory activity against MMPs (matrix metalloproteinase) released from the host immune cells while responding to the microorganisms. [ 9 ] Setiawati E[ 10 ] research inferred that tetracycline can restrain the action of the enzyme collagenase as calculated by means of gingival sulcular fluid.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Antimicrobial Efficacy of Chitosan-Based Tetracycline Gel on Periodontal Pathogens: An In vitro Study

Jalaluddin,

Kulkarni,

Raj

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Aim: The aim of the current research was to evaluate the antimicrobial effectiveness of chitosan-based tetracycline gel on periodontal pathogenic microorganisms. Materials and Methods: Preparation of chitosan-based tetracycline gel of 0.7% and 1% was done. In addition, 0.2 g of chitosan, 1% citric acid, and then 0.35 g of tetracycline in that order was added. Furthermore, 0.5 g of the tetracycline, which had been subjected to crushing and then stirring in a glass beaker to obtain a homogeneous gel was subjected to insertion into the syringe sterile. Such material prepared at the instance will attempt to investigate the sensitivity of bacteria in Surabaya to preserve the steadiness of the material. Evaluation of antimicrobial outcomes of chitosan-based tetracycline gel was performed against Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Results: The highest region of inhibition was noted at 28.26 ± 1.08 mm, 23.98 ± 2.02 mm against A. actinomycetemcomitans and P. gingivalis at 1% chitosan-based tetracycline gel, in pursuit by the 0.7% chitosan-based tetracycline gel at 15.12 ± 0.16 mm and 14.48 ± 1.22 mm region of inhibition, followed by a control group that exhibited 4.16 ± 1.29 mm and 4.82 ± 1.20 mm regions of inhibition against either of the pathogens. Conclusion: To conclude, the chitosan-based tetracycline gel is efficient in restraining the growth of A. actinomycetemcomitans and P. gingivalis bacteria. Tetracycline 1% gel-based chitosan exhibited maximum antibacterial action since it depicted the maximum inhibition region diameter versus tetracycline gel 0.7%.

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Section: Discussionmentioning

confidence: 99%

Assessment of Antimicrobial Efficacy of Chitosan-Based Tetracycline Gel on Periodontal Pathogens: An In vitro Study

Jalaluddin,

Kulkarni,

Raj

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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“…El uso de fármacos para el control del biofilm dental es parte importante para prevenir la aparición de enfermedades periimplantarias como son la mucositis o periimplantitis 5,6 dado que así el implante se coloque sumergido es invadido por el biofilm dental 17 . La clorhexidina es el fármaco más utilizado para el control del biofilm dental pero no quiere decir que sea la mejor alternativa, Figura 3.…”

Section: Discussionunclassified

“…Dentro del surco periimplantario no solo existen bacterias periodontopatógenas Gram negativas anaerobias sino también Gram positivas anaerobias, siendo el ambiente en las profundidades del surco muy adecuado para el crecimiento de bacterias anaerobias 1 . Para el control del biofilm dental se han usado diferentes fármacos, entre ellos la clorhexidina y tetraciclina 5,6 . La clorhexidina es la más investigada y la más usada pero tiene efectos secundarios locales como son tinción de dientes, encía y mucosa , tinción de restauraciones, cambio del gusto, formación de cálculos 5 y también está demostrado que los residuos de la clorhexidina afecta la fisicoquímica del titanio por lo cual la respuesta biológica a la superficie del implante no sería la adecuada 7 , mientras que las tetraciclina no tiene efectos secundarios locales y tiene efectos osteogénicos en estudios experimentales 8,9 .…”

Section: Introductionunclassified

“…Fortes et al 12 encontraron un alto nivel de descontaminación frente a bacterias específicas del biofilm dental utilizando la tetraciclina hidroclorada en solución y en pasta seguido del digluconato de clorhexidina sobre la superficie de implantes dentales. Setiawati 6 realizó un estudio utilizando diferentes concentraciones de gel de tetraciclina y reportó la inhibición del crecimiento del biofilm dental subgingival.…”

Section: Introductionunclassified

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Efecto antimicrobiano de tetraciclina 2% y clorhexidina 0,12% sobre biofilm dental de pilares de cicatrización

Arízaga-Rujel

Guerrero

García-Linares

2021

Odontol Sanmarquina

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Objetivo. Comparar el efecto antimicrobiano de la tetraciclina en gel al 2% y de la clorhexidina en gel al 0,12% sobre el biofilm dental de pilares de cicatrización en implantes dentales. Métodos. Estudio experimental en laboratorio, de corte transversal. Se tomaron 25 muestras de biofilm dental presente en los pilares de cicatrización de implantes dentales de la zona en contacto con la mucosa del surco periimplantario de 19 pacientes. Las muestras fueron sembradas en placas Petri con agar Schaedler, a las cuales se les hizo tres pocillos, en uno se colocó tetraciclina en gel al 2%, en otro clorhexidina en gel al 0,12% y en el último agua destilada en cantidades iguales. Las placas Petri fueron incubadas a 37 °C en medio anaerobio por 96 horas luego de los cuales se midieron los halos de inhibición. Resultados. Ambos geles inhibieron el crecimiento de biofilm dental. La tetraciclina en gel al 2% obtuvo mayores diámetros de halos de inhibición que la clorhexidina en gel al 0,12%, con un máximo de 51 mm y 17 mm respectivamente y un mínimo de 21 mm y 10 mm respectivamente, con medias de 35 mm y 12.84 mm respectivamente. Conclusiones. La tetraciclina en gel al 2% tuvo un mayor efecto antimicrobiano en comparación a la clorhexidina en gel al 0,12% sobre el biofilm dental tomado de pilares de cicatrización de implantes dentales.

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“…8 Persiapan bentuk bahan antimikroba yang akan ditempatkan secara lokal pada jaringan periodontal dapat berupa gel, fiber, strip dan chip. 9 Hidrogel merupakan bahan polimetrik yang memiliki kemampuan untuk mempertahankan komponen air dengan jumlah yang signifikan dan mampu bertahan selama mungkin dalam sukus gingiva dikarenakan hidrogel bersifat hidrofilik. 10 Sodium alginat merupakan polimer natural yang sudah banyak digunakan untuk perawatan beberapa tipe luka oleh karena sifat biokompabilitas, biodegradibilitas dan kemampuan untuk membentuk hidrogel.…”

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The Effectiveness of Aloe vera Hydrogel Against Fusobacterium nucleatum

Susanto¹,

Girsang

2020

IJPST

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Bacteria can cause infectious diseases on oral health such as gingivitis and periodontitis. Scaling and rootplaning are effective against this disease, nevertheless several types of antimicrobial material can be added to increase the effectiveness of the initial treatment. Aloe vera is one of the natural antimicroba materials that is usually used. Hydrogel is a polymetric material that is stable in wet conditions, especially in the gingival sulcus. Sodium alginate is a natural polymer that is often used to produce hydrogels due to its biocompability. The aim of this study was to know the the effectiveness of Aloe vera hydrogel against Fusobacterium nucleatum by in vitro method. This research is experimental research with a total of 20 samples. The samples used were 5% and 10% sodium alginate based Aloe vera hydrogel which were placed in pure culture of F. nucleatum in MHA media for 24 hours. The inhibition zone diameter were measured using calipers. The results of the study using Shapiro-Wilk normality test showed that the data were not normally distributed. Then Kruskal Wallis test was performed which showed significant differences in each treatment group followed by Post Hoc Mann Whitney test to see a significant difference in the 5% group and 10%. Aloe vera hydrogel showed a significant inhibition against F. nucleatum bacteria at both 5% and 10% concentrations.Keywords: Alginate, Aloe vera, Antimicrobial material, Fusobacterium nucleatum, Hydrogel, Inhibitory zone

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The effectiveness of 0.5–0.7% tetracycline gel to reduced subgingival plaque bacteria

Cited by 3 publications

References 6 publications

Assessment of Antimicrobial Efficacy of Chitosan-Based Tetracycline Gel on Periodontal Pathogens: An In vitro Study

Assessment of Antimicrobial Efficacy of Chitosan-Based Tetracycline Gel on Periodontal Pathogens: An In vitro Study

Efecto antimicrobiano de tetraciclina 2% y clorhexidina 0,12% sobre biofilm dental de pilares de cicatrización

The Effectiveness of Aloe vera Hydrogel Against Fusobacterium nucleatum

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