The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

Abstract

Cardiovascular events due to decompensated lipid metabolism are commonly found in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients using anti-retroviral therapy (HAART). Thus, the aim of this study was to identify the effect of a bioactive food compound (BFC) containing functional foods on individuals with HIV undergoing HAART. Particularly, this study aims to verify the clinical outcome in the change of the lipid profile due to the use of this compound. This study includes 115 individuals with HIV on HAART. All patients received dietary guidelines; however, sixty-one consumed BFC while fifty-one did not (NO BFC). Biochemical examinations and socio-demographic and clinical profiles were evaluated. As result, in patients using hypolipidemic and/or hypoglycemic drugs, there was 28.6% decrease in triglyceride levels (p < 0.001) in the NO BFC group, and 18.3% reduction in low density lipoprotein cholesterol (LDL-C) (p < 0.001) in the BFC group. In patients who did not use hypolipidemic and/or hypoglycemic drugs in the NO BFC group, there was 30.6% increase in triglycerides, 11.3% total cholesterol and 15.3% LDL-C levels (p < 0.001) while for the BFC group there was 4.5% reduction in total cholesterol (p < 0.001). In conclusion, this study evidenced that the dietary intervention containing BFC positively affected in lipid control, since these HIV/AIDS patients using HAART are more vulnerable to lipid disorders.

Effectiveness of a bioactive food compound in anthropometric measures of individuals with HIV/AIDS: A nonrandomized trial

“…Previous results indicate that BFC exerts an antiatherogenic effect on glycemic control and reduces triglycerides [ 9 , 10 ], which is probably due to its chemical composition, its high linolenic acid, soluble fibers and isoflavone contents, and the benefits observed in this study.…”

“…Database”), there were few changes: 20 more participants in the expected sample amount and inclusion of one more study variable, the Conicity Index. Regarding the bromatological, microbiological and sensory analysis of the BFC and the lipid profile after consumption have already been published in other manuscripts [ 9 , 10 ].…”

“…In this perspective, functional foods play an important role in lipid metabolism, especially when their components are combined, potentializing their effect when consumed over time [ 6 , 7 ]. In preliminary studies [ 8 – 10 ], a Bioactive Food Compound (BFC) was developed using a combination of functional foods: flaxseed, oat bran and soybean textured protein. Effective results were obtained for the reduction of serum lipids, such as total cholesterol (TC), Low Density Lipoprotein (LDL-C) and triglycerides (TG), in HIV patients with decompensated lipid metabolism due to effects of HAART regimens.…”

Do Bioactive Food Compound with Avena sativa L., Linum usitatissimum L. and Glycine max L. Supplementation with Moringa oleifera Lam. Have a Role against Nutritional Disorders? An Overview of the In Vitro and In Vivo Evidence

“…Some effects from functional foods, such as Avena sativa L. (oats), Linum usitatissimum L. (brown flaxseed), Glycine max L. (soya) and Moringa oleifera, have been presented for nutritional disorders through in vitro and in vivo tests [ 16 , 17 , 18 , 19 , 20 ], NCT04314258 ( Table 1 and Table 2 ). In the literature, there is vast knowledge of the benefits of these functional foods.…”

“…In the literature, there is vast knowledge of the benefits of these functional foods. However, a formulation, called a bioactive food compound (BFC), showed efficiency in the association of oats, flaxseed and soy for dyslipidemia and obesity [ 17 , 18 ].…”