The effectiveness of a gel containing an active substances’ combination in the treatment of post-inflammatory hyperpigmentation

Суркичин, С. И.; Gryazeva, N. V.; Круглова, Л. С.

doi:10.17116/klinderma20212004172

Cited by 1 publication

(1 citation statement)

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“…After title/abstract screening of 2157 articles and full text review of 166 articles, ultimately 41 articles were included in this study representing 877 patients (Figure 1, Table S1). 10–50 Ten studies were level of evidence 1, 30 studies were level of evidence 2, and 1 study was level of evidence four. Study types included placebo‐controlled trials ( n = 2), non‐placebo‐controlled trials ( n = 8), cohort studies ( n = 30) and case series ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

Post‐inflammatory hyperpigmentation: A systematic review of treatment outcomes

Kashetsky,

Feschuk,

Pratt

2023

Acad Dermatol Venereol

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Post‐inflammatory hyperpigmentation is a common consequence of inflammatory dermatoses. It is more common in patients with darker skin and has significant morbidity. This systematic review summarizes treatment outcomes for post‐inflammatory hyperpigmentation to help physicians better predict clinical response and improve patient outcomes. Embase, MEDLINE, PubMed databases and clinicaltrials.gov were searched in accordance with PRISMA guidelines using a combination of relevant search terms. Title, abstract, and full text screening were done in duplicate. Studies were included if they met our predetermined PICOS framework criteria. Results are presented in descriptive form. In total, 41 studies, representing 877 patients were included. Complete response was achieved by laser and energy‐based devices in 18.1% (n=56/309) of patients, topicals in 5.4% (n=20/369), and combination therapies in 2.4% (n=4/166). Partial response was achieved by combination modalities in 84.9% (n=141/166) of patients, topicals in 72.4% (n=267/369), laser and energy‐based devices in 61.2% (n=189/309), and peels in 33.3% (n=5/15). Poor to no response occurred with peels in 66.7% (n=10/15) of patients, topicals in 22.2% (n=82/369), laser and energy‐based devices in 18.1% (n=56/309), and combination modalities in 12.7% (n=21/166). Additionally, in 2.6% (n=8/309) of patients treated with laser and energy‐based devices, post‐inflammatory hyperpigmentation worsened. Adverse events were reported in 10 patients, all while using topical treatments. In conclusion, the current treatment approaches yielded unsatisfactory rates of complete response. However, combination therapies, laser and energy‐based devices, and topical therapies showed high rates of partial response. Of note, the majority of post‐inflammatory hyperpigmentation cases included were associated with acne, and therefore the findings and conclusions drawn may have limited applicability to other types of post‐inflammatory hyperpigmentation.

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Section: Resultsmentioning

confidence: 99%