2019
DOI: 10.1016/j.wneu.2018.11.076
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The Effectiveness of Antiepileptic Medications as Prophylaxis of Early Seizure in Patients with Traumatic Brain Injury Compared with Placebo or No Treatment: A Systematic Review and Meta-Analysis

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Cited by 50 publications
(38 citation statements)
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“…Post-traumatic seizures (PTS) can be seen early (after the first seven days of the trauma) and late (after the 7 th day after the trauma) after traumatic brain injury, and have the potential to induce secondary injury and post-traumatic epilepsy in the traumatic brain. Thus, the use of prophylactic antiepileptic drugs in patients with traumatic brain injury is recommended, albeit controversial [13,14] . This practice has been adopted by the appropriate clinics of our hospital, and antiepileptic treatment is routinely added to the treatment in cases where brain damage is predicted to occur.…”
Section: Discussionmentioning
confidence: 99%
“…Post-traumatic seizures (PTS) can be seen early (after the first seven days of the trauma) and late (after the 7 th day after the trauma) after traumatic brain injury, and have the potential to induce secondary injury and post-traumatic epilepsy in the traumatic brain. Thus, the use of prophylactic antiepileptic drugs in patients with traumatic brain injury is recommended, albeit controversial [13,14] . This practice has been adopted by the appropriate clinics of our hospital, and antiepileptic treatment is routinely added to the treatment in cases where brain damage is predicted to occur.…”
Section: Discussionmentioning
confidence: 99%
“…significantly reduced the heightened cortical excitation in these mice. It is currently thought that antiepileptic medications have little therapeutic impact early after TBI (Wat et al, 2019) and there is even less evidence suggesting efficacy in later phases for reducing post-traumatic epilepsy (Temkin et al, 1990;Thompson et al, 2015). Because of urgent medical need (Temkin, 2009), the potential value of a dampener of TBI-induced cortical excitation in helping TBI patients should be considered.…”
Section: Discussionmentioning
confidence: 99%
“…Seizure probabilities and the development of epilepsy (post-traumatic epilepsy) are increased in cases of TBI. Early after trauma, the probability of seizures is relatively high, making anticonvulsant treatment a relatively standard procedure despite only small proven efficacy (Wat et al, 2019). Although seizure likelihood decreases after the first few weeks of injury, posttraumatic epilepsy develops later in TBI patients and is associated with affective, neurocognitive, and psychosocial disruption of life (Semple et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…A child with a brief generalized seizure following mTBI within the first 24 hours who recovers rapidly and with no complications is low risk and does not need prophylaxis, but children with more severe presentations, structural abnormalities, and significant EEG abnormalities are treated for longer periods and should be individualized. [107][108][109]…”
Section: Posttraumatic Seizures and Epilepsymentioning
confidence: 99%