The effectiveness of benzimidazole derivatives for the treatment and prevention of histomonosis (blackhead) in turkeys

Hegngi, F.N; Doerr, J. A.; Cummings, Timothy S.; Schwartz, Roger D.; Saunders, Geoffrey K.; Zajac, Anne M.; Larsen, C. T.; Pierson, F. W.

doi:10.1016/s0304-4017(98)00233-7

Cited by 24 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So it seems possible that the bacteria with which histomonads are grown inactivate the compounds within a short time. This also would explain the efficacy of benzimidazole against H. meleagridis in vivo where the compounds were applied continuously (Hegngi et al 1999) in contrast to the negative results obtained in vitro where the compounds were only added in the beginning. …”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Partial sequence of the beta-tubulin of Histomonas meleagridis and the activity of benzimidazoles against H. meleagridis in vitro

Hauck

Hafez

2008

Parasitol Res

View full text Add to dashboard Cite

The protozoan parasite Histomonas meleagridis is a member of the family Monocercomonadidae in the class Trichomonada. Due to food safety concerns, currently no prophylactic or therapeutic drug against the parasite is licensed in the European Union. Benzimidazoles are antiparasitic drugs, and some of them are licensed for use in food-producing animals. Benzimidazoles act on beta-tubulin, and the beta-tubulin sequence allows predictions about the efficacy of benzimidazoles. In this study, we sequenced and analyzed a part of the beta-tubulin gene of five H. meleagridis strains and of Dientamoeba fragilis. In each Histomonas strain, three to five different sequences were found. No clustering of sequences from the same strain was recognizable. A phylogenetic tree based on the amino acid sequences of trichomonal beta-tubulin genes placed the histomonal sequences on a branch with D. fragilis, separate from Monocercomonas sp. and Tritrichomonas foetus. All histomonal amino acid sequences predicted a susceptibility to benzimidazoles. However, when we tested the efficacy of five benzimidazoles, namely, albendazole, fenbendazole, flubendazole, mebendazole, and nocodazole, on H. meleagridis in vitro, all tested drugs showed no efficacy, even though the concentrations tested were higher than the concentrations found to be effective against Trichomonas vaginalis and T. foetus by other investigators.

show abstract

Section: Discussionmentioning

confidence: 59%

“…Hu and McDougald (2004) and Callait et al (2002) did not find activity of albendazole, fenbendazole, or mebendazole against histomonads in vitro. However, indications that albendazole and fenbendazol might be effective against histomoniasis in vivo were found (Hegngi et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Partial sequence of the beta-tubulin of Histomonas meleagridis and the activity of benzimidazoles against H. meleagridis in vitro

Hauck

Hafez

2008

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The "ideal" anthelmintic should have a broad spectrum of activity against mature and immature parasites (including hypobiotic larvae), be easy to administer, have a wide margin of safety and be compatible with other compounds and be cost effective. A broad range of anthelmintics have been used against helminths such as albendazole and fenbendazole for their effectiveness in the treatment and prevention of histomoniasis (black head) in turkeys by Hegngi et al (1999), levamisole against gastrointestinal nematodes in common peafowl (Pavo cristatus) by Ashraf et al (2002) in different climatic areas. Good management practices and the chemotherapy are two major methods of suppressing parasitic infestation in birds, however, good management alone is not enough and the need of chemotherapy to get optimum growth gain and production in birds cannot be under rated.…”

Section: A Study Of Gastro-intestinal Helminths In Native Peafowl Andmentioning

confidence: 99%

A Study of Gastro-Intestinal Helminths in Native Peafowl and Comparative Efficacy of Albendazol and Pyrantel Pamoate against the Helminth Parasites

Basit¹

2014

J. Inf. Mol. Biol.

View full text Add to dashboard Cite

The study was conducted to determine the infection rate of helminths in peafowls and to evaluate the comparative efficacy of two broad spectrum anthelmintics. For this purpose, fecal samples of 87 different breeds of peafowls were collected and tested for the presence of helminths. Fecal samples were examined by direct smear and centrifugal floatation methods for qualitative examination. For quantitative examination McMaster Egg Counting Technique was used. We found that 56.32% (49 out of 87) peafowls were positive for gastrointestinal helminths. Single or mixed infection of Heterakis gallinae, Ascaridia galli, Davainea proglottina, Capillaria columbae and Acuaria spiralis was present with their individual percentage was 36.73%, 26.53%, 6.12%, 18.37% and 12.24%, respectively. Out of these 49 birds 48 positive birds were divided in 3 groups A, B and C, each comprising of 16 birds. The uninfected and untreated birds were kept in group D. Chemotherapeutic trials were conducted to the birds of group A and B. While group C served as positive control and group D served as negative control for chemotherapeutic trials. Group A was treated with Albendazole 0.1ml/kg body weight and group B was treated with Pyrantel pamoate (0.1 mL /kg body weight). We found that Albendazole is more effective against gastrointestinal helminths having 94.92% efficacy as compare to Pyrantel pamoate which showed 78.34% efficacy on 10 th day of drug treatment. All copyrights reserved to Nexus® academic publishers

show abstract

“…Callait et al () showed that ALB is ineffective in the treatment of Histomonas meleagridis (turkey blackhead), one of the most important diseases of turkeys. However, another study indicated that ALB can be effective in protection of turkeys against Heterakis gallinarum or flagellated form of Histomonas (Hegngi et al , ). Clinical effectiveness in the treatment of turkeys infected by Ascaridia dissimilis is described for homologous drug fenbendazole (Yazwinski et al , ).…”

Section: Introductionmentioning

confidence: 99%

Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys

Grabowski

Jaroszewski

Swierczewska

et al. 2011

Biomed. Chromatogr.

View full text Add to dashboard Cite

Methods for determination of albendazole (ALB), albendazole sulfoxide (SOX) and albendazole sulfone (SON) in turkey blood plasma, using high-performance liquid chromatography (HPLC) with fluorescence detection, were developed. Moreover, comparison of HPLC columns with ultra-performance liquid chromatography (UPLC) columns was performed. Albendazol was administered orally in 5-week-old birds (n = 18) at a dose of 25 mg/kg b.w. Accuracy and precision of the developed method were satisfactory and stability studies showed acceptable variation (below 15%) in ALB, SOX and SON concentrations when the samples were stored at -75°C for 15 days. UPLC(®) columns gave higher peaks from typical HPLC columns retaining high quality of analysis. Pharmacokinetic analysis indicated quick elimination of ALB from turkey blood plasma. The mean residence time of SON was at least two times longer than that of SOX and four times longer than that of ALB. The elimination half-lives for ALB, SOX and SON were 0.7 ± 0.27, 5.37 ± 6.03, 9.17 ± 5.12 h, respectively. The obtained results indicate that the described method allows for precise determination of albendazole and its metabolites in turkey plasma. Moreover, using UPLC columns in HPLC apparatus results in higher sensitivity as compared with the classical HPLC columns.

show abstract

The effectiveness of benzimidazole derivatives for the treatment and prevention of histomonosis (blackhead) in turkeys

Cited by 24 publications

References 7 publications

Partial sequence of the beta-tubulin of Histomonas meleagridis and the activity of benzimidazoles against H. meleagridis in vitro

Partial sequence of the beta-tubulin of Histomonas meleagridis and the activity of benzimidazoles against H. meleagridis in vitro

A Study of Gastro-Intestinal Helminths in Native Peafowl and Comparative Efficacy of Albendazol and Pyrantel Pamoate against the Helminth Parasites

Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys

Contact Info

Product

Resources

About