The effectiveness of berberine on noise-induced hearing loss: a rat model

Kılıç, Korhan; Sakat, Muhammed Sedat; Şahin, Abdulkadir; Yıldırım, Serkan; Dörtbudak, Muhammet Bahaeddi̇n

doi:10.1590/1806-9282.20220758

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Berberine partially reverses the detrimental effects of acoustic trauma. Rats with acoustic trauma who are treated with 100 mg/kg of berberine for five consecutive days exhibit minimal histopathological changes and a reduction in the 8-OHdG expression in the spiral ganglion of Corti and OHCs [111].…”

Section: Berberinementioning

confidence: 98%

“…In vivo experiments confirm these observations. Recently, Kilic et al [111] described the efficacy of berberine on noise-induced ROS accumulation in rats. Acoustic trauma (rats exposed to white noise for 12 h; 4 kHz, 110 dB) causes severe histopathological impairment of cochlear structures along with elevation of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage.…”

Section: Berberinementioning

confidence: 99%

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The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

Lazzeri,

Biagioni,

Ferrucci

et al. 2023

IJMS

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Tinnitus is the perception of noise in the absence of acoustic stimulation (phantom noise). In most patients suffering from chronic peripheral tinnitus, an alteration of outer hair cells (OHC) starting from the stereocilia (SC) occurs. This is common following ototoxic drugs, sound-induced ototoxicity, and acoustic degeneration. In all these conditions, altered coupling between the tectorial membrane (TM) and OHC SC is described. The present review analyzes the complex interactions involving OHC and TM. These need to be clarified to understand which mechanisms may underlie the onset of tinnitus and why the neuropathology of chronic degenerative tinnitus is similar, independent of early triggers. In fact, the fine neuropathology of tinnitus features altered mechanisms of mechanic-electrical transduction (MET) at the level of OHC SC. The appropriate coupling between OHC SC and TM strongly depends on autophagy. The involvement of autophagy may encompass degenerative and genetic tinnitus, as well as ototoxic drugs and acoustic trauma. Defective autophagy explains mitochondrial alterations and altered protein handling within OHC and TM. This is relevant for developing novel treatments that stimulate autophagy without carrying the burden of severe side effects. Specific phytochemicals, such as curcumin and berberin, acting as autophagy activators, may mitigate the neuropathology of tinnitus.

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Section: Berberinementioning

confidence: 98%

Section: Berberinementioning

confidence: 99%

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

Lazzeri,

Biagioni,

Ferrucci

et al. 2023

IJMS

View full text Add to dashboard Cite

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Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

Santaolalla Sanchez,

Gutierrez Posso,

Santaolalla Montoya

et al. 2024

Antioxidants

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Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs’ administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss.

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The effectiveness of berberine on noise-induced hearing loss: a rat model

Cited by 2 publications

References 20 publications

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

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