The effectiveness of broncho-alveolar lavage for the pathogen detection in children with pulmonary tuberculosis

Russkikh, Anastasiia; Veselova, Elena; Lovacheva, Olga; Клевно, Н. И.; Panova, Anna; Gracheva, Alexandra; Samoilova, Anastasia; Vasilyeva, Irina

doi:10.1183/13993003.congress-2021.oa4206

Cited by 1 publication

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“…Полученную в процессе проведения БАЛ жидкость подвергали исследованию, в том числе с применением молекулярно-генетических методов (например, с применением теста GeneXpert), что позволяло обнаружить в полученном материале ДНК МБТ. Так, у пациентов с отрицательными результатами микробиологических исследований мокроты при проведении процедуры бронхоскопии с БАЛ из зоны поражения отмечено повышение качества этиологической диагностики на 60% (95% доверительный интервал (ДИ) 43,6-74,5), при этом в 14,3% случаев обнаружены МБТ с множественной/широкой лекарственной устойчивостью (МЛУ/ШЛУ) [8] с последующим изменением химиотерапии. Другим методом получения материала для подтверждения наличия МБТ являлась индукция мокроты, выполняемая с помощью ультразвукового распыления гипертонического физиологического раствора [9].…”

Section: диагностика туберкулеза легких с недоказанным бактериовыделе...unclassified

Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review)

Tyulkova¹,

Lugovkina²,

Kutuzova³

et al. 2022

Russian Medical Inquiry

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The authors analyzed 31 scientific publications, which highlighted modern methods to the diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (PTB). In the article, such clinical cases are classified into two groups due to the absence of the tuberculosis causative agent. This approach can serve as a justification for choosing optimal and appropriate additional methods and techniques for diagnosing bacteriologically unconfirmed PTB. Given the fact that bacterial excretion is determined by traditional microbiological methods (microscopic and cultural) in sputum, the literature review presents data on additional measures for obtaining biological material for the etiological diagnosis of tuberculosis, using molecular genetic methods for detecting Mycobacterium tuberculosis DNA. Besides, the article shows the diagnostic significance of immunological and serological tests for the tuberculosis diagnosis, as well as modern methods to the X-ray results interpretation, using mathematical methods that evaluate the dynamic X-ray imaging. A special place in the bacteriologically unconfirmed PTB diagnosis is occupied by the description of biopsy material using artificial intelligence. That is, the integration of medicine and information technology achievements allows us having a source of additional information that should help the doctor diagnose tuberculosis in difficult clinical cases. KEYWORDS: tuberculosis, oligobacillar forms of tuberculosis, sputum smear-negative tuberculosis, diagnosis, bacteriologically unconfirmed, diagnostic material, immunological methods, radiation methods, mathematical methods. FOR CITATION: Tyulkova T.E., Lugovkina T.K., Kutuzova D.M., Khabibullina N.F. Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review). Russian Medical Inquiry. 2022;6(7):387–392 (in Russ.). DOI: 10.32364/2587-6821-2022-6-7-387-392.

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Section: диагностика туберкулеза легких с недоказанным бактериовыделе...unclassified

Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review)

Tyulkova¹,

Lugovkina²,

Kutuzova³

et al. 2022

Russian Medical Inquiry

View full text Add to dashboard Cite

show abstract

The effectiveness of broncho-alveolar lavage for the pathogen detection in children with pulmonary tuberculosis

Cited by 1 publication

References 0 publications

Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review)

Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review)

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