The Effectiveness of Clinical Pharmacist Intervention in Reducing Drug Related Problems of Childhood Acute Lymphoblastic Leukemia Patient in Tangerang District General Hospital, Indonesia

Budiastuti, Rizky Farmasita; Radji, Maksum; Purnamasari, Rini

doi:10.7454/psr.v6i1.3966

Cited by 5 publications

(12 citation statements)

References 8 publications

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“…Children ≤ 6 years old accounted for most cases, at nearly 80.0%. Males accounted for a higher rate than females, at about 1.2%, similar to previous studies on DRPs in children [8,14,15,17,19,20]. The primary diseases, comorbidity status, and the total number of drugs in the prescription differed significantly between the two phases (p < 0.001).…”

Section: Characteristics Of the Study Populationsupporting

confidence: 87%

“…The intervention study of R.F. Budiastuti (2019) in pediatric patients with acute lymphoblastic leukemia reduced the number of DRPs from 177 pre-intervention to 10 postintervention. In this study, the pharmacist intervened by reporting and discussing DRPs face-to-face with the physicians, nurses, and dietitians to adjust treatment therapies [20].…”

Section: Drps In Prescriptions Pre-and Post-interventionmentioning

confidence: 99%

“…Marcela Urtasuna et al reported that implementing electronic prescription systems in the management of prescriptions resulted in a decrease of 30% in medication errors in pediatric patients [18]. In addition, there is considerable evidence supporting the role of clinical pharmacists in detecting and minimizing the DRPs occurrence, particularly DRPs in relation to the pediatric prescribing process [19][20][21]. In Vietnam, many healthcare facilities have some problems with inappropriate prescribing, including the overuse of antibiotics and vitamins, over-prescribing of medication, and inadequate prescription drugs instructions.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Pharmacist-Led Interventions on Physicians’ Prescribing for Pediatric Outpatients

Nguyen

et al. 2022

Healthcare

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Background: Children are at high risk of drug-related problems, increased risk of treatment failures, and high treatment costs. We aimed to evaluate the effect of pharmacist-led interventions on physicians’ prescribing for pediatric outpatients. Methods: A prospective study with pre- and post-intervention measurement assessment was conducted to collect pediatric outpatients’ prescriptions during the pre-intervention period (January 2020) and post-intervention (August 2020) at a children’s hospital in Vietnam. Drug-related problems were identified and categorized according to Pharmaceutical Care Network Europe (PCNE), version 9.1. The intervention program was developed based on the results of pre-intervention observations. After the intervention, prescriptions were evaluated. Statistical tests were used to compare the proportions of drug-related problems before and after the intervention and to identify factors related to drug-related problems. Results: There were 2788 out of 4218 (66.1%) prescriptions with at least one drug-related problem before the intervention. Of these drug-related problems, the most common was inappropriate timing of administration and incorrect dosage (36.1% and 35.6%, respectively). After the intervention, the percentage of prescriptions with at least one drug-related problem was 45.5% (p < 0.001). Most of the drug-related problem types decreased significantly (p < 0.05). The binary logistic regression analysis results showed that in addition to pharmacists’ intervention, patients’ gender, primary disease, comorbidity status, and the total number of drugs prescribed were also factors related to drug-related problems. Conclusions: Drug-related problems in pediatric outpatients were quite common. Pharmacists’ intervention helped to improve the prevalence and types of drug-related problems.

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Section: Characteristics Of the Study Populationsupporting

confidence: 87%

Section: Drps In Prescriptions Pre-and Post-interventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Pharmacist-Led Interventions on Physicians’ Prescribing for Pediatric Outpatients

Nguyen

et al. 2022

Healthcare

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“…Our results were similar to those reported in other studies regarding the proportion of significant drug-drug interactions recorded in outpatient prescriptions, of about 1% [ 24 , 28 ]. Drug-drug interaction rates were usually higher in pediatric inpatients, but with fluctuations only of around 10% [ 8 , 9 , 29 ]. The above results showed that drugs used with pediatric patients were less likely to have clinically significant drug-drug interactions.…”

Section: Discussionmentioning

confidence: 99%

Drug-Related Problems in Prescribing for Pediatric Outpatients in Vietnam

Nguyen

Quach

et al. 2021

Healthcare

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Background: Our study was conducted to determine the prevalence of drug-related problems (DRPs) in outpatient prescriptions, the impact of DRPs on treatment efficacy, safety, and cost, and the determinants of DRPs in prescribing for pediatric outpatients in Vietnam. Methods: A retrospective cross-sectional study was conducted on pediatric outpatients at a pediatric hospital in Can Tho, Vietnam. DRPs were classified according to the Pharmaceutical Care Network Europe classification (PCNE) of 2020. The study determined prevalence of DRPs and their impacts on efficacy, safety, and cost. Multivariate regression was used to identify the determinants of DRPs. Results: The study included 4339 patients (mean age 4.3, 55.8% male), with a total of 3994 DRPs, averaging 0.92 DRP/prescription. The proportion of prescriptions with at least one DRP was 65.7%. DRPs included inappropriate drug selection (35.6%), wrong time of dosing relative to meals (35.6%), inappropriate dosage form (9.3%), inappropriate indication (7.1%), and drug-drug interactions (0.3%). The consensus of experts was average when evaluating each aspect of efficiency reduction, safety reduction, and treatment cost increase, with Fleiss’ coefficients of 0.558, 0.511, and 0.541, respectively (p < 0.001). Regarding prescriptions, 50.1% were assessed as reducing safety. The figures for increased costs and decreased treatment effectiveness were 29.0% and 23.9%, respectively. Patients who were ≤ 2 years old were more likely to have DRPs than patients aged 2 to 6 years old (OR = 0.696; 95% CI = 0.599–0.809) and patients aged over 6 years old (OR = 0.801; 95% CI = 0.672–0.955). Patients who had respiratory system disease were more likely to have DRPs than patients suffering from other diseases (OR = 0.715; 95% CI = 0.607–0.843). Patients with comorbidities were less likely to have DRPs than patients with no comorbidities (OR = 1.421; 95% CI = 1.219–1.655). Patients prescribed ≥ 5 drugs were more likely to have DRPs than patients who took fewer drugs (OR = 3.677; 95% CI = 2.907–4.650). Conclusion: The proportion of prescriptions in at least one DRP was quite high. Further studies should evaluate clinical significance and appropriate interventions, such as providing drug information and consulting doctors about DRPs.

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“…Table 1 provides an overview of the study's characteristics. This evaluation included a total of 17 studies from eleven different nations 8–24. These 17 studies include four from Ethiopia, 9,10,15,24 two each from China, 12,14 Indonesia, 16,18 France, 17,23 and each study from India, 8 Belgium, 11 Brazil, 13 Turkey, 19 Nigeria, 20 Kenya, 21 and Singapore.…”

Section: Resultsmentioning

confidence: 99%

Drug-related problems in cancer patients: A systematic review

Venugopal,

et al. 2024

J Oncol Pharm Pract

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Background Cancer patients are at a significantly increased risk of drug-related problems due to multiple drugs. An inclusive review of drug-related problems would offer an approach for healthcare providers to decrease the frequency of drug-related problems in cancer patients. The purpose of this study was to assess all characteristic components of drug-related problems in cancer patients, and explore actions taken to resolve the detected drug-related problems the results could be used as a baseline for epidemiology and potential related risk factors for drug-related problems in cancer patients. Methods The present systematic review was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search consisted of studies listed from January 2015 and up to May 2023. A systematic review was carried out using an electronic database with a combination of Medical subject Headings of key words Medical Subject Heading terms. Results This evaluation included 17 studies from 11 different nations having 11 prospective and 6 retrospective studies. Pharmaceutical Care Network Europe classification system is the most commonly used to classify the drug-related problems. The prevalence of drug-related problems varied from 9.6% to 92.8%. The key predictors of the drug-related problems were age, polypharmacy, multiple comorbidities, and the stage of the disease. Conclusion Drug-related problems are significantly more common among cancer patients. The age, polypharmacy, multiple comorbidities, and the stage of the malignancy all enhance the risk of acquiring drug-related problems. This review raises awareness of drug-related problems, encourages their early detection, and emphasizes the necessity for framing effective drug-related problem management strategies which will enhance patient care.

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The Effectiveness of Clinical Pharmacist Intervention in Reducing Drug Related Problems of Childhood Acute Lymphoblastic Leukemia Patient in Tangerang District General Hospital, Indonesia

Cited by 5 publications

References 8 publications

Effect of Pharmacist-Led Interventions on Physicians’ Prescribing for Pediatric Outpatients

Effect of Pharmacist-Led Interventions on Physicians’ Prescribing for Pediatric Outpatients

Drug-Related Problems in Prescribing for Pediatric Outpatients in Vietnam

Drug-related problems in cancer patients: A systematic review

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