The Effectiveness of Combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on Quality of Life of Patients with Migraine Headaches: A Randomized, Double Blinded, Placebo - Controlled Clinical Trial

Abstract

Headache is one of the most common public health problems in the world, which causes patients to see a doctor. Migraine is the second most common cause of headaches after tension headaches. This study is a randomized, double blinded, placebo - controlled clinical trial, using SF36 questionnaire, to evaluate the effect of combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on the quality of life, in patients with migraine after 4 weeks. In all domains of the SF36 questionnaire, the scores after intervention in the drug group were significantly higher than the control group after 4 weeks. This study showed that, combination of V. odorata, R. damascena and C. sativum, improves the quality of life of patients with migraine.

Evidence for Rosa damascena efficacy in mental disorders in preclinical animal studies and clinical trials: A systematic review

“…(Keyhanmehr et al, 2018; Khalili, Taraghi, & Ilali, 2021; Khalili, Taraghi, Ilali, & Mousavinasab, 2021). Studies were conducted on individuals who had experienced different types of mental disorders including labor anxiety (Kheirkhah et al, 2013; Valipour et al, 2012), sleep disorder (Babaii et al, 2015; Keyhanmehr et al, 2018), depressive disorder (Esfandiary et al, 2018; Farnia, Hojatitabar, et al, 2015; Farnia, Shirzadifar, et al, 2015; Riazi et al, 2021), preoperative anxiety, and work/exam anxiety (Bikmoradi, Roshanaei, Moradkhani, & Fatahi, 2020; Dagli et al, 2019; Dehkordi et al, 2017; Fazlollahpour‐Rokni et al, 2019; Gholami et al, 2019; Hamdamian et al, 2018; Jodaki et al, 2021; Mirzaee Jirdehi et al, 2021; Najafi et al, 2020; Noorian et al, 2020; Riazi et al, 2021; Sadeghi et al, 2020; Tazakori et al, 2016; Zare et al, 2020), and migraine (Kamali et al, 2019; Maddahian et al, 2017). In reported publications, R. damascena was used as an EO, extract (Esfandiary et al, 2018; Tazakori et al, 2016), essence, and a dried plant (Riazi et al, 2021).…”