The Effectiveness of Combined Use of Antioxidant and Glutamine in Abdominal Sepsis

Назаретьян, В. В.; Лукач, В Н; Kulikov, A.V.

doi:10.15360/1813-9779-2017-2-52-60

Cited by 2 publications

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“…In addition, the inclusion of glutamine in nutritional support for patients with surgical sepsis contributed to a decrease in intoxication, a decrease in hypercatabolism and the restoration of nutritional status at the study stages, which confirms the studies of other authors on the need to include glutamine in the parenteral-enteral nutrition program to prevent mucosal atrophy, stimulate the immune the function of the intestinal lymphoid apparatus and the reduction of bacterial translocation [34].…”

Section: Discussion Of Research Resultssupporting

confidence: 84%

Pediatric surgical sepsis: diagnostics and intensive therapy

Сатвалдиева

Ashurova

Fayziev

et al. 2021

SR:MS

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The aim: Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring. Materials and methods: The research period is 2018-2020. The object of the study (n=73) – children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, abdominal trauma, etc.). Research methods: microbiological monitoring to determine the sensitivity of the microorganism to antibiotics was carried out before and at the stages of treatment (sputum, urine, wound, bronchoalveolar lavage, tracheal aspirate, blood, contents from drainages, wound surface). Determination of the sensitivity of the isolated strains to antibiotics was carried out by the disk-diffusion method. To determine predictors of sepsis in surgical patients, clinical (mean arterial pressure (mAP), heart rate (HR), respiratory rate (RR), SpO2, etc. and laboratory parameters on days 1–2 (up to 48 hours) of sepsis identification, days 4 and 8 of intensive therapy. Procalcitonin was determined by immunofluorescence on a Triage® MeterPro analyzer (Biosite Diagnostics, USA). Blood gases and electrolytes were analyzed using a Stat Profile CCX analyzer (Nova Biomedical, USA). Results: studies have shown the effectiveness of complex intensive care in 86.3 % of cases. Mortality was found in 13.7 % of cases. Patients with severe surgical pathology died: widespread peritonitis, severe TBI + coma with irreversible neurological disorders, urosepsis against the background of chronic renal failure, after repeated surgical interventions, due to the development of refractory septic shock (SS). Conclusions. Early diagnosis of sepsis, rational early ABT under the control of microbiological monitoring, non-aggressive infusion therapy with early prescription of vasopressors (SS) with constant monitoring of the child's main life support organs contribute to an improvement in sepsis outcomes and a decrease in mortality

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Section: Discussion Of Research Resultssupporting

confidence: 84%

Pediatric surgical sepsis: diagnostics and intensive therapy

Сатвалдиева

Ashurova

Fayziev

et al. 2021

SR:MS

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Criteria for choosing antibiotic therapy for surgical sepsis in children

Сатвалдиева

Fayziev

Ashurova³

et al. 2022

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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BACKGROUND: Sepsis is one of the leading causes of hospital mortality in children. A decisive role in improving the results of treatment of this group of patients belongs to early diagnosis and pathogenetic therapy. AIM: This study optimizes the diagnosis and intensive care of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring. MATERIALS AND METHODS: The study period is 20182020. The study subjects were children (n = 73) with surgical pathology (diffuse purulent peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, injuries of the abdominal organs, and others). Clinical and laboratory parameters were analyzed, and microbiological monitoring was performed to determine antibiotic sensitivity. RESULTS: Patients who developed sepsis had a pronounced hypermetabolic syndrome, which was manifested by tachycardia and tachypnea, hyperthermia, low levels of albumin, and total protein in the blood. Protein catabolism in patients was accompanied by a decrease in globulins (IgG) synthesis and the development of a secondary immunodeficiency state. Both gram-positive and gram-negative microorganisms were involved in developing surgical sepsis in children, increasing the proportion of the latter. Given the high proportion of multi-resistant flora, empirical combined de-escalation antibiotic therapy (ABT) with broad-spectrum antibiotics was prescribed. This was followed by its revision based on microbiological monitoring and clinical and laboratory data of the patient with sepsis. Studies have shown the effectiveness of complex intensive care in 86.3% of cases. Mortality occurred in 13.7% of cases. Patients with severe surgical pathology died: fecal, generalized peritonitis, severe traumatic brain injury + coma with irreversible neurological disorders, and urosepsis against the background of chronic renal failure after repeated surgical interventions. CONCLUSIONS: Early diagnosis of sepsis, rational ABT under the control of microbiological monitoring, non-aggressive infusion therapy, and active sanitation of the surgical infection focus contributed to a decrease in mortality in this category of patients.

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The Effectiveness of Combined Use of Antioxidant and Glutamine in Abdominal Sepsis

Cited by 2 publications

References 0 publications

Pediatric surgical sepsis: diagnostics and intensive therapy

Pediatric surgical sepsis: diagnostics and intensive therapy

Criteria for choosing antibiotic therapy for surgical sepsis in children

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