The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway

Babaei, Ayyub; Nourshahi, Maryam; Fani, Maryam; Entezari, Zahra; Jameie, Seyed Behnamedin; Haghparast, Abbas

doi:10.1016/j.jpsychires.2021.02.006

Cited by 20 publications

(8 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intriguingly, inducing a depressive-like state by deprivation of social interaction had no impact on fndc5 expression in either region. It is noteworthy that previous reports have indicated that chronic unpredictable stress protocols reduce hippocampal fndc5 expression in mice ( Babaei et al, 2021 ; Wu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

Lima-Filho

Fortuna

Cozachenco

et al. 2023

eNeuro

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a major cause of disability in adults. MDD is both a co-morbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III domain-containing protein 5 (FNDC5). FNDC5/irisin is reduced in the brains of AD patients and mouse models. However, whether brain FNDC5/irisin expression is altered in depression remains elusive. Here, we investigate changes infndc5expression in post-mortem brain tissue from MDD individuals and mouse models of depression. We found decreasedfndc5expression in the MDD prefrontal cortex, both with and without psychotic traits. We further demonstrate that induction of depressive-like behavior in male mice by lipopolysaccharide decreasedfndc5expression in the frontal cortex, but not in the hippocampus. Conversely, chronic corticosterone administration increasedfndc5expression in the frontal cortex, but not in the hippocampus. Social isolation in mice did not result in alteredfndc5expression in either frontal cortex or hippocampus. Finally, fluoxetine, but not other antidepressants, increasedfndc5gene expression in the mouse frontal cortex. Results indicate a region-specific modulation offndc5in depressive-like behavior and by antidepressant in mice. Our finding of decreased prefrontal cortexfndc5expression in MDD individuals differs from results in mice, highlighting the importance of carefully interpreting observations in mice. The reduction infndc5mRNA suggests that decreased central FNDC5/irisin could comprise a shared pathological mechanism between MDD and AD.Significance StatementMajor depressive disorder (MDD) is a major cause of disability in humans. Physical exercise reduces the incidence and severity of MDD, but molecular mechanisms are elusive. One of the pleiotropic actions of exercise alludes to the increased production and circulation of irisin, a myokine cleaved from fibronectin type III domain-containing protein 5 (FNDC5) that mediates some benefits of exercise in the brain. Here, we observed reducedfndc5expression in post-mortem samples of dorsolateral prefrontal cortex from patients with MDD. In the mouse frontal cortex, modulation offndc5was variable across models of depressive-like behavior. Our findings indicate reducedfndc5expression in MDD with discordant results in mice and stimulate further research on the roles of brain FNDC5/irisin in MDD.

show abstract

Section: Discussionmentioning

confidence: 85%

“…In rodents, a chronic unpredictable stress protocol reduced levels of FNDC5/irisin in the hippocampus ( Babaei et al, 2021 ; Wu et al, 2021 ). In addition, intracerebroventricular administration of irisin (0.5–1 ng) reduced immobility times in the tail suspension and forced swim tests in mice ( Siteneski et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

Lima-Filho

Fortuna

Cozachenco

et al. 2023

eNeuro

View full text Add to dashboard Cite

show abstract

“…As reported, exercise has an antidepressant effect, as it can elevate the level of 5-HT by upregulating peroxisome proliferator-activated receptor γ coactiva-tor-1α (PGC-1α), reducing oxidative stress and the inflammatory response (e.g., IL-6 and TNF-α), decreasing IDO activity, and increasing TRY activity [51]. In addition, the expression of PGC-1α-dependent fibronectin type III domain-containing protein 5 (FNDC5) also increases, inducing the expression of BDNF, one that can regulate FNDC5 gene expression [52]. An animal experiment demonstrated that rats under CUMS exhibited reductions in the expression of PGC-1α and FNDC5 in the skeletal muscle and BDNF in the hippocampus, whereas the three factors showed an increasing trend after exercise [53].…”

Section: Sirt1 Gene Expression Pattern During Exercisementioning

confidence: 99%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. Exercise is an important means to improve energy metabolism and depression, but it remains to be established how SIRT1 acts during exercise and improves depression. By induction and analysis, SIRT1 can be activated by exercise and then improve the function of the hypothalamic–pituitary–adrenal (HPA) axis by upregulating brain-derived neurotrophic factors (BDNF), inhibit the inflammatory response (suppression of the NF-κB and TNF-α/indoleamine 2,3-dioxygenase (IDO)/5-Hydroxytryptamine (5-HT) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (IGF-1) and growth-associated protein-43 (GAP-43) pathways, etc.), thereby improving depression. The present review gives a summary and an outlook based on this finding and makes an analysis, which will provide a new rationale and insight for the mechanism by which exercise improves depression.

show abstract

“…Exercise is known to augment BDNF brain concentrations and ameliorate cognitive performances and depressive symptoms, thus mimicking the effects of direct BDNF administration against chronic stress [ 234 - 238 ]. Programmed and controlled, as opposed to voluntary, exercise training may be able to provide even greater effects in suppressing reward from substance use, due to potentially larger increases in neurotransmitters and neurotrophic factors ( e.g.…”

Section: Role Of Bdnf Enhancers In the Treatment Of Alcohol Abuse In ...mentioning

confidence: 99%

BDNF and its Role in the Alcohol Abuse Initiated During Early Adolescence: Evidence from Preclinical and Clinical Studies

Cutuli

Sampedro-Piquero

2022

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) is a crucial brain signaling protein that is integral to many signaling pathways. This neurotrophin has shown to be highly involved in brain plastic processes such as neurogenesis, synaptic plasticity, axonal growth, and neurotransmission, among others. In the first part of this review, we revise the role of BDNF in different neuroplastic processes within the central nervous system. On the other hand, its deficiency in key neural circuits is associated with development of psychiatric disorders, including alcohol abuse disorder. Many people begin to drink alcohol during adolescence, and it seems that changes in BDNF are evident after the adolescent engaged regularly in alcohol use. Therefore, the second part of this manuscript addresses the involvement of BDNF during adolescent brain maturation and how this process can be negatively affected by alcohol abuse. Finally, we propose different BNDF enhancers, both behavioral and pharmacological, which should be considered in the treatment of problematic alcohol consumption initiated during the adolescence.

show abstract

The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway

Cited by 20 publications

References 71 publications

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

BDNF and its Role in the Alcohol Abuse Initiated During Early Adolescence: Evidence from Preclinical and Clinical Studies

Contact Info

Product

Resources

About