The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania

Roșu, Oana-Maria; Gimiga, Nicoleta; Ştefănescu, Gabriela; Ioniuc, Ileana; Tataranu, Elena; Bălan, Gheorghe G.; Ion, Laura-Mihaela; Pleșca, Doina Anca; Schiopu, Cristina Gabriela; Diaconescu, Smaranda

doi:10.3390/children9091391

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Parenting and childcare practices, including breastfeeding, bottle-feeding, or using a pacifier, are often handled by the mother. 11 On the other hand, some reports suggest that H. pylori infection can be acquired from siblings, mainly from older siblings to younger siblings. 12 , 13 However, few studies on the relationship of H. pylori strains between families and members use molecular genotyping techniques.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Urrutia-Baca,

Gonzalez Brosig,

Salazar-Garza

et al. 2023

CEG

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Purpose Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies have found that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico. Patient and Methods Ninety-nine dental plaque samples from 36 families were studied. Real-time PCR was performed to detect H. pylori using previously reported primers. The Mann–Whitney U -test was used for the statistical analysis. According to the family role of H. pylori -positive individuals, the VacA s1/m1 genotype and CagA gene correlated. Results The mother had the highest expression of VacA s1/m1-/cagA- with 19% (8/42), followed by the first child with 14.3% (6/42). The major roles for the vacA s1/m1+/cagA- were the mother and first child with 9.5% (4/42), followed by the remaining children with 4.8% (2/42). The vacA s1/m1-/cagA+ genotype was 7.1% (3/42) for the mother and 4.8% (2/42) for the father. Finally, the vacA s1/m1+/cagA+ genotype only appeared in the mother, son I, and son III with 2.4% (1/42). Conclusion The vacA s1/m1/cagA genotypes predominated in the mother, suggesting potential transmission between the mother and child during the first years of life.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Urrutia-Baca,

Gonzalez Brosig,

Salazar-Garza

et al. 2023

CEG

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Trends in Upper Gastrointestinal Bleeding in Children: The Impact of Helicobacter pylori Infection and Non-Steroidal Anti-Inflammatory Drug Use

Galos,

Ionescu,

Mirea

et al. 2024

Antibiotics

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Upper gastrointestinal bleeding (UGIB) is a significant concern in children, contributing to 6–20% of cases in pediatric intensive care units. This study evaluates the roles of Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory drug (NSAID) usage in the etiology of UGIB in children, with a particular focus on trends observed during the COVID-19 pandemic. We conducted a retrospective analysis of 103 pediatric patients who underwent esophagogastroduodenoscopy (EGD) for UGIB between January 2015 and December 2023. Of these, 88 patients were included in the final analysis, where the source of bleeding was successfully identified. Hematemesis was the most common presentation, and the source of bleeding was identified in 85.43% of cases. The prevalence of H. pylori infection remained stable across the pre-pandemic (39.7%) and post-pandemic (36.7%) periods. However, NSAID usage increased nearly threefold during the pandemic, with 36.7% of post-pandemic UGIB cases associated with NSAID use, compared to 12.1% pre-pandemic. These findings underscore the significant roles of H. pylori and NSAID use in pediatric UGIB, with a notable increase in NSAID-related cases during the pandemic.

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Bacterial Infections, Trends, and Resistance Patterns in the Time of the COVID-19 Pandemic in Romania—A Systematic Review

Vulcanescu,

Bagiu,

Avram

et al. 2024

Antibiotics

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Background: The COVID-19 pandemic has intensified concerns over bacterial infections and antimicrobial resistance, particularly in Romania. This systematic review explores bacterial infection patterns and resistance during the pandemic to address critical gaps in knowledge. Methods: A systematic review, following PRISMA guidelines, was conducted using databases such as PubMed and Scopus, focusing on studies of bacterial infections from 2020 to 2022. Articles on bacterial infections in Romanian patients during the pandemic were analyzed for demographic data, bacterial trends, and resistance profiles. Results: A total of 87 studies were included, detailing over 20,000 cases of bacterial infections. The review found that Gram-negative bacteria, particularly Escherichia coli and Klebsiella pneumoniae, were the most frequently identified pathogens, alongside Gram-positive Staphylococcus aureus and Enterococcus spp. Multidrug resistance (MDR) was noted in 24% of the reported strains, with common resistance to carbapenems and cephalosporins. Conclusions: The pandemic has amplified the complexity of managing bacterial infections, particularly in critically ill patients. The rise in MDR bacteria underscores the need for stringent antimicrobial stewardship and infection control measures. Continuous monitoring of bacterial trends and resistance profiles will be essential to improve treatment strategies in post-pandemic healthcare settings.

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The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection—A Single-Center Comparative Study from Romania

Cited by 3 publications

References 24 publications

Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Trends in Upper Gastrointestinal Bleeding in Children: The Impact of Helicobacter pylori Infection and Non-Steroidal Anti-Inflammatory Drug Use

Bacterial Infections, Trends, and Resistance Patterns in the Time of the COVID-19 Pandemic in Romania—A Systematic Review

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