The effectiveness of e-health on reducing stigma, improving social support and quality of life among people living with HIV: A systematic review and meta-analysis of randomized controlled trials

Zhang, Liao; Ni, Zhao; Liu, Ying; Chen, Hong

doi:10.1016/j.ijnurstu.2023.104606

International Journal of Nursing Studies

2023

DOI: 10.1016/j.ijnurstu.2023.104606

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The effectiveness of e-health on reducing stigma, improving social support and quality of life among people living with HIV: A systematic review and meta-analysis of randomized controlled trials

Liao Zhang,

Zhao Ni,

Ying Liu

et al.

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Cited by 4 publications

References 51 publications

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The associations of e-health perception and dementia knowledge with dementia public stigma in nursing students: A cross-sectional study

Su,

Tsui,

Lam

et al. 2025

Nurse Education Today

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The associations of e-health perception and dementia knowledge with dementia public stigma in nursing students: A cross-sectional study

Su,

Tsui,

Lam

et al. 2025

Nurse Education Today

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The impact of Chatbot-Assisted Self Assessment (CASA) on intentions for sexual health screening in people from minoritised ethnic groups at risk of sexually transmitted infections

Nadarzynski,

Knights,

Husbands

et al. 2024

Sex. Health

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Background Sexually transmitted infections (STIs) present a significant global public health issue, with disparities in STI rates often observed across ethnic groups. The study investigates the impact of Chatbot-Assisted Self Assessment (CASA) on the intentions for sexual health screening within minoritised ethnic groups (MEGs) at risk of STIs as well as the subsequent use of a chatbot for booking STI screening. Methods A simulation within-subject design was utilised to evaluate the effect of CASA on intentions for STI/HIV screening, concern about STIs, and attitudes towards STI screening. Screening intentions served as the dependent variable, while demographic and behavioural factors related to STI/HIV risk were the independent variables. ANCOVA tests were conducted to measure the impact of CASA on these perceptions. Results Involving 548 participants (54% women, 66% black, average age = 30 years), the study found that CASA positively influenced screening intentions t(547) = −10.3, P < 0.001], concerns about STIs t(544) = −4.96, P < 0.001, and attitudes towards sexual health screening [t(543) = −4.36, P < 0.001. Positive attitudes towards CASA were observed (mean, 13.30; s.d., 6.73; range, −17 to 21). About 72% of users who booked STI screening appointments via chatbot were from MEGs. Conclusion CASA increased motivations for STI screening intentions among ethnically diverse communities. The intervention’s non-judgemental nature and the chatbot’s ability to emulate sexual history-taking were critical in fostering an environment conducive to behavioural intention change. The study’s high acceptability indicates the potential for broader application in digital health interventions. However, the limitation of not tracking actual post-intervention behaviour warrants further investigation into CASA’s real-world efficacy.

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Limited Impact of Cannabidiol on Health-related Quality of Life of People With Long-term Controlled HIV: A Double-blind, Randomized, Controlled Trial

Barré,

Couton,

Mourad

et al. 2024

Open Forum Infectious Diseases

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Background People living with HIV (PWH) with undetectable HIV viral load still have an impaired health-related quality of life (HRQoL). Cannabidiol (CBD) is a non-intoxicating cannabis-derived cannabinoid that holds promise for the treatment of many ailments. In the present study, we tested whether oral CBD-rich medication could significantly improve PWH’s HRQoL. Methods Eighty participants with undetectable HIV viral load were randomized to either a placebo or full-spectrum CBD (1 mg/kg twice a day) arm for 12 weeks plus a 4-week follow-up period. HRQoL was assessed at baseline, week 12 and week 16 using the SF-36 questionnaire. Primary outcomes were physical and mental component summary scores; secondary outcomes were the eight SF-36 subscale scores. Treatment effects on outcomes were estimated using generalized estimating equations. Results We found no effect of CBD intake on the summary score for either component. However, CBD intake was associated with a higher physical functioning score at W12 only (regression coefficient [95% confidence interval] 7.72 [0.55 ; 14.89], p=0.035). No significant main effect of CBD intake on the other HRQoL subscale scores was observed. Furthermore, there was no difference in self-reported adverse effects between the two arms. Conclusion Twice daily CBD full-spectrum oil at 1 mg/kg had no major effect on virologically suppressed PWH’s HRQoL, but had a positive effect on physical functioning. Further randomized controlled trials including PWH with lower baseline HRQoL are needed to confirm this finding.

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The effectiveness of e-health on reducing stigma, improving social support and quality of life among people living with HIV: A systematic review and meta-analysis of randomized controlled trials

Cited by 4 publications

References 51 publications

The associations of e-health perception and dementia knowledge with dementia public stigma in nursing students: A cross-sectional study

The associations of e-health perception and dementia knowledge with dementia public stigma in nursing students: A cross-sectional study

The impact of Chatbot-Assisted Self Assessment (CASA) on intentions for sexual health screening in people from minoritised ethnic groups at risk of sexually transmitted infections

Limited Impact of Cannabidiol on Health-related Quality of Life of People With Long-term Controlled HIV: A Double-blind, Randomized, Controlled Trial

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