The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Abstract

FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.

Comparison of an Intraoperative Application of a Haemostatic Agent (PerClot<sup>&reg</sup>) with Conventional Haemostatic Procedure after Thyroid Resection

“…Compared to other haemostatic agents, e.g. FloSeal ® (210 €/application [6]) or TachoSil ® (9.5 × 4.8 cm 210 €/application [30]), the costs are quite moderate. Further investigations using a higher dosage of PerClot ® powder are planned in a similar setting to further explore the haemostatic effect and possible influence on postoperative bleeding complications.…”

“…Haemostatic fleeces were shown to be superior to conventional methods in reaching a fast and effective haemostasis in cardiovascular surgery [24]. There are few studies investigating the usage of local haemostatic agents in neck surgery and thyroid surgery [6] [7] [11] [13]- [15] [25] [26]. After a systematic review of the literature, there has been no study that investigated the benefits of PerClot ® in the reduction of postoperative bleeding after thyroid resection.…”

“…Since the development of the capsular dissection by Thomson et al [3] [4], morbidity rates even decreased. Surgical technique and experience of the surgeon in the field of thyroid surgery are important for an uncomplicated perioperative course [5] [6]. The major complications of thyroidectomy are the laceration of the parathyroid glands, the injury of the recurrent laryngeal nerve (RLN), and a postoperative hemorrhage [7] [8].…”

“…Also, it is difficult to satisfy oozing-type bleeding near vulnerable anatomic structures, such as the RLN and the parathyroid glands [7]. In recent years, various topical haemostatic agents have been widely used in thyroid surgery as in other surgical disciplines [6] [7] [11]- [15]. PerClot ® (Starch Medical, Inc.; San Jose, CA) consists of dry, sterile, polysaccharide particles manufactured from purified plant starch using proprietary modification processes [16] [17].…”

Effectiveness of Ankaferd Blood Stopper on salivary gland bleeding

“…[1,2] Son birkaç yılda, cerrahi işlem sırasında hemostazı artırmak için çeşitli topikal hemostatik ajanlar ve yapıştırıcılar kullanılmaya başlanmıştır. [3] Ankaferd "Blood Stopper" (ABS) ülkemizde yeni kullanıl-maya başlayan kan durdurucu bir ajandır. Etkisini koagülasyon faktörleri yoluyla değil, fizyolojik olarak eritrosit agregasyonu yoluyla göstermektedir.…”