The Effectiveness of Glucomannan and Nano Activated-Carbon as Hypercholesterol-Lowering Agents

Abstract

Porang (konjac) plants have long been used as a food source and traditional medicine. Glucomannan derived from porang has been utilised for various uses such as antidiabetic and antihypercholesterolemia agent. This paper studies the mixture of porang flour and nano activated-carbon and its effect on the cholesterol activity of rats. The mixture of porang and activated carbon were subjected to test for male Sprague Dawley rats to test the antihypercholesterolemia activity. The result showed that concerted anticholesterol activity of porang and nano activated-carbon revealed the cholesterol level decreases in rat's blood. However, the different treatments of unleached and leached porang either leached porang and nano activated-carbon applied in the experiments showed that the levels of cholesterol decrease were slightly different (16–18%). Low glucomannan content as the alleged anticholesterol agent was regarded quite effective in lowering the cholesterol level in rat's blood and comparable with those of simvastatin which achieved 18% reduction. Therefore, it indicates potential utilisation as a functional food for a cholesterol-lowering agent. The involvement of activated carbon in the alleged anticholesterol agent (leached porang flour) did little in enhancing the cholesterol level decrease in rat's blood. The glucomannan in both leached porang flour and leached porang flour + nano activated-carbon shows potential utilisation as an anticholesterol agent. Yet, raw (unleached) porang is prospectively potential as a functional food for cholesterol-lowering.

AKTIVITAS ANTIOBESITAS TEPUNG UMBI SUWEG (Amorphophallus paeoniifolius) PADA MODEL TIKUS OBESITAS

“…Tepung umbi suweg ditimbang sebanyak 300 gram kemudian diekstraksi dengan metode remaserasi dengan cara direndam dengan 4500 ml (4,5 L) etanol 50% dan 300 mL NaHSO3 kemudian dilakukan pengadukan selama 4 jam, lalu disaring dengan alat corong buchner dan diambil ampasnya (Pasaribu et al, 2020;Saputro et al, 2014). Ampas yang diperoleh selanjutnya dikeringkan di atas loyang menggunakan oven pada suhu 45 ֯ C selama 24 jam untuk mengurangi kandungan air.…”

“…Adanya pengadukan selama pencucian diharapkan dapat mempermudah pelepasan komponen pada permukaan butiran glukomanan dan larut dalam etanol. Rasio tepung terhadap pelarut yang digunakan dapat mempengaruhi kandungan glukomanan, dimana semakin banyak pelarut yang digunakan dengan perbandingan (1:15), maka semakin tinggi hasil jumlah glukomanan (Pasaribu et al, 2020). Dengan metode ekstraksi ini dapat diperoleh nilai randemen yaitu 50,60% (Tabel 1).…”

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

“…It can also be activated in drug delivery sets. AC could be a great alternative to carrier drugs in cancer therapeutic agents [41].…”

Purification and separation of glucomannan from porang tuber flour (Amorphophallus muelleri) using microwave assisted extraction as an innovative gelatine substituent

“…As a result, microwave heating is considered a valuable and effective technology for extraction purpose. Pasaribu et al [ 14 ] successfully increased the extracted glucomannan levels from 32.65 % to 83.96 % by utilizing 50 % (v/v) of ethanol with the addition of 2 % sodium bisulfite solution (NaHSO 3 ). However, it takes a long extraction time of up to 4 h. Bui et al [ 15 ] claimed that Microwave-assisted extraction (MAE) using hydrochloric acid (HCl) solvent can reduce the extraction time to 15 min.…”