Background: Statistics show that, neonatal mortality (NNM) accounts for approximately 40% of the under-five mortality globally. The risk factors are varied but cut across all nations. The purpose of this study was to empower the expectant adolescent mothers through 'evidence-based health education' hence reduce NNM. The study objectives were; to identify, describe and find solutions to the risk factors through health education. Methods: the study was carried out at Busia County Referral Hospital (BCRH), Western Kenya using a cross-sectional interventional design. 226 expectant adolescent mothers attending the antenatal clinic were randomly sampled. Expectant adolescent mothers aged ≤19 years, 26-34 weeks gestation and residents of Busia County were selected. Mothers with co-morbidities, students and non-Kenyans were excluded. Ethical approvals from KNH/UONREC, BCRH; Director of Health, County Government of Busia were obtained. Data was collected using semi-structured researcher-administered questionnaires. Analysis utilized Epi Data 3.1, STATA version 8.0, Microsoft excel and reported in frequencies and percentages. Intervention: respondents were grouped in 20s of same gestation. A pragmatic approach was used to cushion respondents from making many trips to the hospital. The sessions were conducted by the researcher who after each overview, allowed respondents to share experiences. Results: risk factors identified; lack of knowledge-84.5%, poor infrastructure-83.6%, negligence-81% non-breastfeeding-80.1%, lack of emphasis on neonatal care by the community-77% and prematurity-67.3%. 87% of the respondents applauded the intervention. Discussion: the respondents expressed desire for neonates to be recognized and valued at home. Conclusion: risk factors that contributed to NNM were of duo play, involving respondents and the community. This revealed gaps in information acquisition, awareness and neonatal care practices. Recommendation: there is need for space and age-specific care tailored to adolescent mothers and the need to step-up and intensifies health education strategies.