The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children

Nuhoğlu, Yonca; Bahceciler, Nerin N.; Barlan, Işıl; Başaran, Müjdat

doi:10.1016/s1081-1206(10)63306-6

Cited by 42 publications

(25 citation statements)

References 12 publications

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“…27 Repeated doses of budesonide over 3 days resulted in similar pulmonary and pulmonary function indices to prednisolone in an open study. 28 Schuh et al obtained different results when assessing children over five years old with severe acute asthma. Patients treated with fluticasone via metered-dose inhaler, exhibited a worse response to treatment when compared with those who were prescribed oral prednisone.…”

Section: Discussionmentioning

confidence: 99%

Budesonida inalatória em crianças com asma aguda

Milani¹,

Filho²,

Riedi³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To investigate the efficacy of a single dose of inhaled budesonide as compared to oral prednisone in patients with acute asthma.Methods: Randomized double-blind, double-dummy and placebo-controlled clinical trial. Fortynine children aged 2 to 7 years with acute asthma were randomized in three groups after receiving nebulized salbutamol (0.15 mg/kg). Group I received placebo both as tablets and nebulization, group II was treated with a single dose of oral prednisone (1 mg/kg) and inhaled placebo, and group III received a single dose of placebo tablet and nebulized budesonide (2 mg). Patients were evaluated in terms of symptom score and transcutaneous hemoglobin saturation. Nebulized salbutamol was repeated in case of increasing symptom score or lower saturation.Results: Progressive clinical improvement was observed in all three groups. However, a significant increase in hemoglobin saturation was observed after 2 hours with prednisone, 4 hours with budesonide, and 24 hours with placebo. Conclusion:A combination of single-dose nebulized budesonide and salbutamol may be as effective as oral prednisone to improve symptom severity, but the latter increases hemoglobin saturation in exacerbation of asthma.J Pediatr (Rio J). 2004;80(2):106-12: Budesonide, acute asthma, prednisone, inhaled steroids.

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Section: Discussionmentioning

confidence: 99%

Budesonida inalatória em crianças com asma aguda

Milani¹,

Filho²,

Riedi³

et al. 2004

J. Pediatr. (Rio J.)

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“…46,47 When therapy combining ICS and systemic CS is used, studies yield mixed results. [48][49][50] Overall, without further data, ICSs appear to play a marginal role in treating severe acute asthma. Though ICS may be effective in treating mild asthma symptoms in children at home, systemic CS should be used in moderate to severe exacerbations.…”

Section: Corticosteroidsmentioning

confidence: 99%

Assessment and Treatment of Acute Asthma in Children

Chipps

Murphy

2005

The Journal of Pediatrics

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“…Increasing evidence indicates that inhalation of high-dose corticosteroids (ICS) is beneficial when it is initiated early. [55][56][57] However, data on ICS in children are inconsistent. [58] A meta-analysis showed that inhaled steroids reduced admission rates of patients with acute asthma.…”

Section: Epinephrinementioning

confidence: 99%