The Effectiveness of Hyaluronic Acid in Controlling Pain, Edema, and Trismus After Extraction of Third Molars: Systematic Review and Meta-Analysis

Souza, Glaciele Maria de; Elias, Gabriel Mariano; Andrade, Pedro Figueiredo Pereira de; Sales, Késsia N. A.; Galvão, Endi Lanza; Falci, Saulo Gabriel Moreira

doi:10.1016/j.joms.2020.07.005

Cited by 12 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, 19 eligible meta-analyses were retrieved (Figure 1). Seven types of complementary interventions were identified among the retrieved meta-analyses including PRF application [12,[27][28][29][30][31][32], LLLT [33], [6,[34][35][36][37], Kinesio taping [8,38], cryotherapy [11], surgical drainage [9], ozone therapy [7], and hyaluronic acid application [10].…”

Section: Identification Of the Eligible Meta-analysesmentioning

confidence: 99%

“…On the other hand, nonpharmacological complementary interventions are proposed to enhance pain relief, and reduce analgesic use, mitigating the unwanted e ects and contraindications of allopathic medications [6][7][8][9][10][11][12]. is goal is especially important in reducing or eliminating the use of opioid analgesics.…”

Section: Introductionmentioning

confidence: 99%

“…ey include the application of low-level laser therapy (LLLT) [13], cryotherapy [11], application of platelet-rich fibrin (PRF) [12], application of hyaluronic acid [10], ozone therapy [7], application of drainage [9], and kinesio taping (sports tapes) [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses

Firoozi

Falci

Kim

et al. 2022

Pain Research and Management

Self Cite

View full text Add to dashboard Cite

Objectives. To provide a nonbiased, complete assessment of what the evidence from meta-analyses informs us about complementary and nonpharmacological treatment options for the management of pain after third molar surgery, as well as highlight any discordancy, gaps, or lack of evidence among meta-analyses. Methods. The quality of the included systematic reviews was assessed using the ROBIS tool. Corrected covered area (CCA) was calculated for pairs of similar meta-analyses to identify the amount of overlap. Reviews that were the most recent, comprehensive, and had adequate quality were considered for analyses when reviews showed a high overlap. In cases with a low amount of overlap among meta-analyses, all eligible studies were included. Also, citation matrices were constructed to address overlap. A network meta-analytical approach was adopted to rank different interventions. Results. Ten meta-analyses were included for quantitative synthesis. The quantitative analysis revealed that platelet-rich fibrin and its derivatives as well as ozone therapy reduce early and late pain better than the other complementary interventions compared to control (no complementary intervention). Conclusions. Despite the shortcomings of included meta-analyses, consolidated evidence suggests that platelet-rich-fibrin and its derivatives as well as ozone therapy outperform the other nonpharmacological complementary interventions in reducing early and late postsurgical pain following third molar extraction. However, the results should be interpreted with caution due to an unclear risk of bias and lack of firm evidence in the included meta-analyses. Moreover, there is a need for a standard protocol for the application of nonpharmacological complementary interventions.

show abstract

Section: Identification Of the Eligible Meta-analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses

Firoozi

Falci

Kim

et al. 2022

Pain Research and Management

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hyaluronic acid (HA) is a biocompatible, high-molecular glycosaminoglycan that is found in the connective tissue and synovial fluid. It regulates tissue hydration and mechanism of cell detachment [ 5 , 6 ]. HA has been shown to conduct a wide range of functions in previous investigations.…”

Section: Introductionmentioning

confidence: 99%

Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal

Altaweel

Gaber

Alnaffar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. Extraction of impacted molars is commonest operation in oral cavity and associated with complications disturbing patient’s quality of life. Hyaluronic acid is a nontoxic agent recommended for wound management due to its anti-inflammatory effects. Also, methylprednisolone sodium is used to reduce pain and edema. The aim this study was to compare the effect of combined use of corticosteroid and hyaluronic acid versus each agent alone in controlling postextraction complications of impacted mandibular third molars. Materials and Methods. This prospective randomized trial included patients suffering from impacted mandibular third molar. Patients were divided into four groups. Group I, control, and group II received methylprednisolone sodium succinate injection preoperatively, group III received hyaluronic acid applied in extraction socket, and group IV received preoperative methylprednisolone sodium succinate injection and topical hyaluronic acid in the socket. All patients were evaluated preoperatively and postoperative day to assess swelling, pain, mouth opening, and total analgesic dose. Results. Group IV showed insignificant edema along the study period, and other groups showed significant edema on third postoperative day that improved on seventh postoperative in group II and III and tenth postoperative day in group I. Significant decreased mouth opening occurred on second postoperative day in group I, while in other groups, it occurred in third postoperative day. Significant improvement occurred on seventh postoperative day in all groups except in group I which occurred on tenth postoperative day. There was less pain and analgesic dose reported in group IV than other groups. Conclusion. Combined use of methylprednisolone sodium succinate and hyaluronic acid significantly decrease postoperative complications than using each agent alone.

show abstract

“…When applied in combination with L-PRF, superior soft tissue healing (Afat et al, 2019), less oedema, and lower intake of analgesics have been reported (Afat et al, 2018). Furthermore, a recent systematic review showed that application of HA resulted in greater reduction of pain levels but had no influence on postoperative trismus (Maria de Souza et al, 2020). Conflicting results have been published in terms of prevention and treatment of alveolitis by HA application (Guazzo et al, 2018;Afat et al, 2019;Suchánek et al, 2019;Muñoz-Cámara et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled trial evaluating hyaluronic acid gel as wound healing agent in alveolar ridge preservation

Eeckhout

Julie

Glibert

et al. 2021

J Clinic Periodontology

View full text Add to dashboard Cite

Aim: To compare the results of administration of hyaluronic acid (HA) gel to no gel administration following alveolar ridge preservation (ARP) in terms of changes in wound dimensions over time.Materials and Methods: Systemically healthy patients scheduled for ARP at one or two sites in the incisor, cuspid, or premolar area with at least one neighbouring tooth and >50% buccal bone present following extraction were included. ARP consisted of socket grafting with collagen-enriched, deproteinized bovine bone mineral and socket sealing by means of a collagen matrix. Following surgical therapy, sites were randomly allocated to the control group (no gel application) or the test group (0.8% HA gel applied onto the collagen matrix three times per day for 7 days). Bucco-lingual and mesio-distal wound dimensions were registered at T0 (immediately post operation), T1 (1 week), and T2 (3 weeks). Patient-reported outcomes, clinical outcomes, and hard and soft tissue changes were recorded up to 4 months (T3).Results: In the control group, 20 patients (7 males, 13 females; mean age 53.30) with 23 sites, and in the test group 18 patients (9 males, 9 females; mean age 52.56) with 23 sites, were included. There were no significant differences between the groups in the changes in wound dimensions from T0 to T2 (bucco-lingual aspect: p = .340; mesio-distal aspect: p = .883). Three sites (13%) in the control group and six (26%) in the test group demonstrated complete wound resolution at T2 (p = .259). HA failed to show any effect on the number of analgesics taken (p = .175), patient-reported outcomes (p ≥ .263), alveolitis (p = .136), socket healing (p ≥ .424), soft tissue changes (p ≥ .064), or mucosal scarring (p = .548).However, significantly more horizontal bone loss at the coronal aspect was found in the test group (p ≤ .025). Conclusion:HA failed to promote wound resolution on a collagen matrix.This study was registered in ClinicalTrials.gov (NCT04467736).

show abstract

The Effectiveness of Hyaluronic Acid in Controlling Pain, Edema, and Trismus After Extraction of Third Molars: Systematic Review and Meta-Analysis

Cited by 12 publications

References 28 publications

Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses

Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses

Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal

A randomized controlled trial evaluating hyaluronic acid gel as wound healing agent in alveolar ridge preservation

Contact Info

Product

Resources

About