The Effectiveness of Hyperbaric Oxygen Therapy in Severe Idiopathic Sudden Sensorineural Hearing Loss

Ahn, Yeji; Seo, Young Joon; Lee, Young Sub

doi:10.5152/iao.2021.9182

Cited by 16 publications

(11 citation statements)

References 18 publications

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“…Combining steroids with HBOT is useful because it can reduce inflammation and improve hypoxia. There are reports that HBOT combination showed superior hearing improvement effects in patients with hearing loss ≥80 dB at the first visit (16) and that it promotes initial hearing improvement in patients with severe hearing loss of 60 to 79 dB (17). However, it should be used before irreversible changes occur in cochlear hair cells, and it was reportedly less effective in conditions with severe inflammation that cause irreversible changes (1).…”

Section: Discussionmentioning

confidence: 99%

Indications of Effective Hyperbaric Oxygen Therapy Combined With Steroid Therapy for Sudden Hearing Loss

Ohira,

Komori,

Tsuna

et al. 2023

Otol Neurotol

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Objective This study evaluated the therapeutic effect of hyperbaric oxygen therapy (HBOT) combined with steroid therapy to treat sudden hearing loss and examined the index associated with excellent therapeutic effect. Methods We included 109 patients with sudden hearing loss. Patients were divided into the HBOT combination group (59 sides) treated with HBOT and steroid therapy and HBOT noncombination group (50 sides) involving steroid therapy only. The recovery rate of each group was compared according to the severity of hearing loss. Blood samples were evaluated and inflammatory markers, such as neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR), were calculated and compared by severity. We evaluated the usefulness of inflammatory markers for predicting recovery rate, and calculated cutoff values were also evaluated. Results The HBOT combination group exhibited a higher overall recovery rate than the HBOT noncombination group, particularly in severe cases. However, there was no significant difference in the severity of hearing loss based on various inflammatory markers. NLR and PLR are useful for predicting the effect in patients treated with concomitant HBOT. By setting 2.43 and 146.67 as cutoff values for NLR and PLR, respectively, we observed that lower values resulted in better recovery rates. Conclusion The use of HBOT is effective for severe cases and early blood flow disorders with low NLR and PLR and less inflammation. When determining treatment, not only should the severity of hearing loss be considered, but also the NLR and PLR should be evaluated and examined based on the cutoff values.

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Section: Discussionmentioning

confidence: 99%

Indications of Effective Hyperbaric Oxygen Therapy Combined With Steroid Therapy for Sudden Hearing Loss

Ohira,

Komori,

Tsuna

et al. 2023

Otol Neurotol

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“…Some studies reported that HBO therapy is better for those with initial severe hearing loss [ 2 , 7 , 8 , 10 ]. Some studies indicate that patients with moderate ISSHL are improved by HBO therapy along with oral steroids, but HBO therapy is ineffective for patients with severe and profound hearing losses [ 16 , 19 ]. Another study reported that HBO therapy plus systemic steroid and ITS treatment show no gain in hearing regardless of the severity in hearing loss [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Sudden Sensorineural Hearing Loss: Is Hyperbaric Oxygen Treatment the Sooner and Longer, the Better?

Chin

Lee

Chen

et al. 2022

JPM

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(1) Background: We aimed to evaluate hearing benefits from hyperbaric oxygen (HBO) therapy in patients with Idiopathic Sudden Sensorineural Hearing Loss (ISSHL). (2) Methods: We performed a retrospective analysis of chart reviews on patients with ISSHL between Jan 2016 and Dec 2021. All patients were referred to receive HBO therapy by the department of Ear, Nose and Throat (ENT). Hearing gain was assessed based on pure-tone audiometry (PTA). Data were analyzed for 102 patients after 1 to 5 therapy sessions, and for 46 patients after 6 to 10 therapy sessions. (3) Results: After 1–5 HBO sessions, patients (N = 102) showed an improvement in 45 (44.1%) of the patients (p < 0.000). Also, improvements were found with patients showing different grades of ISSHL: 11 (26.8%) with slight-moderate, 11 (40.7%) with severe, and 23 (67.6%) with profound ISSHL. Significant treatment effects were found at different affected frequencies, especially the low frequency range. After 6–10 HBO sessions, patients (N = 46) showed similar treatment effects as after 1–5 HBO sessions, but no additional improvement. Moreover, patients who received HBO treatment within 12 days showed improvement effects 6.484 times greater (p < 0.000) compared with those who received treatment after 13 days. (4) Conclusions: The improvement of HBO therapy on ISSHL was significant after 1–5 sessions, with larger improvements for those suffering more serious symptoms. Further adding more HBO treatment sessions to 6–10, no further improvement was found. Patients starting HBO therapy within 12 days of ISSHL showed 6.484 times greater improvements compared with those starting HBO therapy later.

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“…Although several hearing‐loss etiologies have been proposed, including viral infection, vascular disturbance, and immune‐mediated mechanisms, the causes of inner‐ear disorders, including sudden sensorineural hearing loss, noise‐induced hearing loss, Meniere's disease, and presbycusis, are unclear. 1 Several studies have investigated inner‐ear disorders and impaired cochlear blood flow in animal models. Abnormal cochlear microcirculation has long been considered a crucial cause of noise‐induced hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Circulatory disturbance of the cochlear spiral modiolar artery in a type 2 diabetic mouse model

Seo

Shim

Sharif

et al. 2022

Laryngoscope Investig Oto

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Objective This study aimed to identify significant differences in cochlea microvessel size between a diabetic mouse model (db/db) and normal mice using three‐dimensional (3D) quantitative analysis. Methods Six control heterozygote db/+ as well as 18 male B6/BKS(D)‐Lepr db /J (db/db) mice aged 14 ( n = 9) and 28 ( n = 9) weeks were examined. After clearing the cochlea, we reconstructed the 3D volumes of the spiral modiolar artery (SMA) in the cochlea using light‐sheet microscopy and analyzed vessel wall thickness, cross‐sectional area, short and long diameter, and vessel height. Results The average SMA‐wall thickness in the db/db‐mouse group (3.418 ± 0.328 μm) was greater than that in the control group (2.388 ± 0.411 μm). The average cross‐sectional outer area, short diameter, and long diameter of the SMA in db/db mice were significantly larger than those in control mice (all p < 0.001). The cross‐sectional areas increased with age (control: 221.782 ± 121.230 μm, 14 weeks; 294.378 ± 151.008 μm, and 28 weeks; 312.925 ± 147.943 μm). Conclusion The db/db mice had thicker and larger proximal‐SMA vessel walls and diameters than control mice, respectively, thus potentially inducing increased blood viscosity or vascular insufficiency and aggravating hearing loss in type 2 diabetes mellitus. Level of Evidence IIb

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The Effectiveness of Hyperbaric Oxygen Therapy in Severe Idiopathic Sudden Sensorineural Hearing Loss

Cited by 16 publications

References 18 publications

Indications of Effective Hyperbaric Oxygen Therapy Combined With Steroid Therapy for Sudden Hearing Loss

Indications of Effective Hyperbaric Oxygen Therapy Combined With Steroid Therapy for Sudden Hearing Loss

Idiopathic Sudden Sensorineural Hearing Loss: Is Hyperbaric Oxygen Treatment the Sooner and Longer, the Better?

Circulatory disturbance of the cochlear spiral modiolar artery in a type 2 diabetic mouse model

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