The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure

Baltacı, Volkan; Ayvaz, Özge Üner; Ünsal, Evrim; Aktaş, Yasemin; Baltaci, A.; Turhan, Feriba; Özcan, Sarp; Sönmezer, Murat

doi:10.1016/j.fertnstert.2009.03.107

Cited by 51 publications

(27 citation statements)

References 19 publications

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“…In our previous study; we obtained very encouraging results of piezoelectric combined ICSI in Total Fertilization Failure (TFF) patients and reported apregnancy rate of 12.8% [11]. Yanagida et al…”

Section: Groupsmentioning

confidence: 86%

“…The protocols and procedures for ovarian stimulation and oocyte handling have been published previously [11]. Fertilization was assessed 12-16 hours post microinjection.…”

Section: Ovarian Stimulation and Embryo Developmentmentioning

confidence: 99%

“…Several methods have been used for activation of oocytes after ICSI such as electrical activation [11][12][13][14], mechanical activation [15,16], and chemical activation such as ethanol [17], Ca 2+ ionophores [18][19][20], strontium [21] and 6-dimethylaminopurine (6-DMAP) [10,22,23].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Piezoelectric Stimulation in Patients with Low Fertilization Potential

Ünsal¹

2014

Human Genet Embryol

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Objective: To assess the value of the electrical activation of oocytes in ICSI patients with previous limited fertilization outcomes.Design: Prospective randomized study. Settings Result(s):Patients were subdivided into six study groups. In Group I, testicular elongated spermatids were used and 27.9% fertilization, 2.3% clinical pregnancy rates were evaluated. In testicular immotile spermatozoa injected group (Group II), 56.5% fertilization and 50% clinical pregnancy rates were obtained. 66.7% fertilization and 30%clinical pregnancy rates were achieved in Group III with testicular motile spermatozoa. In Group IV, patients with severe oligozoospermia, 64% fertilization and 28.6% clinical pregnancy rates were achieved. Group V included patients with total immotile spermatozoa and fertilization and clinical pregnancy rates were 50% and 57.1% respectively. In patients with history of low fertilization rate (Group VI), 38.7% fertilization and 19% clinical pregnancy rates were obtained. Conclusion(s):Piezoelectric stimulation can be used for patients with low fertilization rates and total immotile spermatozoa; as we detected an improvement in the fertilization and clinical pregnancy rates of these patients.

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Section: Groupsmentioning

confidence: 86%

“…The protocols and procedures for ovarian stimulation and oocyte handling have been published previously [11]. Fertilization was assessed 12-16 hours post microinjection.…”

Section: Ovarian Stimulation and Embryo Developmentmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Piezoelectric Stimulation in Patients with Low Fertilization Potential

Ünsal¹

2014

Human Genet Embryol

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“…378 Although an instance of spontaneous activation has been reported, 379 post-ICSI failure to fertilize is most likely due to the inability of the oocyte to activate. 15 Artificial oocyte activation (AOA) protocols using calcium ionophores, 380,381 strontium chloride, 382 or electrical impulses 383,384 have therefore been used. However, despite reassuring reports on obstetric, neonatal, and 1-year-old children, the routine use of AOA warrants caution, as alterations in calcium oscillations are associated with alterations in gene expression and embryonic development in a mouse model.…”

Section: Risk Of Fertilization Failurementioning

confidence: 99%

Assisted Reproduction

Ginsburg¹,

Racowsky²

2014

Yen &Amp; Jaffe's Reproductive Endocrinology

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“…Des échecs de pénétration spermatique sont plus souvent incriminés en FIV [1,3,[6][7][8][9][10], et des défauts d'activation et maturation ovocytaires en ICSI [1,3,7,11,12] ; mais les causes des échecs de fécondation peuvent être multiples et restent encore mal connues, malgré les nombreuses recherches sur le sujet.…”

Section: Introductionunclassified