The effectiveness of lamotrigine for persistent depressive disorder: A case report

Matsuzaka, Yusuke; Urashima, Kayoko; Sakai, S.; Morimoto, Yoshiro; Kanegae, Shinji; Kinoshita, Hirohisa; Imamura, Akira; Ozawa, Hiroki

doi:10.1002/npr2.12228

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Used off-label for bipolar disorder [179]. Could potentially offer an effective option in addressing individuals with treatment-resistant persistent depressive disorder, being a viable substitute for the combination of antidepressant and benzodiazepine therapies in this disorder [180].…”

Section: Lamotriginementioning

confidence: 99%

Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

Correia,

Vale

2024

IJTM

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Major depressive disorder (MDD), a prevalent mental illness, is marked by a complex mixture of biological factors. This review focuses on the roles of oxidative stress, tryptophan-serotonin metabolism, brain-derived neurotrophic factor (BDNF), and the hypothalamic–pituitary–adrenal (HPA) axis in MDD’s pathophysiology. Oxidative stress, defined as an imbalance between pro-oxidants and antioxidants, is closely linked to MDD’s neurobiological changes. The tryptophan (TRP)-/serotonin (5-HT) metabolic pathway is also known to be crucial in mood regulation, with its dysregulation being a central aspect of MDD. Additionally, BDNF, key for neuronal growth and plasticity, often shows alterations in MDD patients, supporting its role in the disorder’s progression. Furthermore, the HPA axis, which manages stress response, is frequently disrupted in MDD, further contributing to its complex pathology. In addition to exploring these biological mechanisms, this review also explores the pharmacotherapy of MDD, including new advances. These advancements in treatment strategies are crucial for managing MDD effectively. Understanding these mechanisms and the latest pharmacological interventions is essential for developing more effective treatments for MDD.

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Section: Lamotriginementioning

confidence: 99%

Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

Correia,

Vale

2024

IJTM

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“…Lamotrigine has advantages beyond its usage in treating epilepsy and bipolar disorder, according to findings from two blinded studies and many open trials for individuals with severe mental disability and refractory epilepsy [ 59 ]. Overall, while lamotrigine was originally developed for the treatment of epilepsy, its unique mechanism of action and favorable effects on psychological well-being have made it a promising option for the management of bipolar disorder and other conditions [ 60 ].…”

Section: Overview Of Antiepileptic Drugsmentioning

confidence: 99%

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Costa

Vale

2023

IJMS

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The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. Recent studies have highlighted the involvement of LTG in modulating the activity of voltage-gated ion channels, particularly those related to the inhibition of neuronal excitability. Additionally, LTG has been found to have neuroprotective effects, potentially through the inhibition of glutamate release and the enhancement of GABAergic neurotransmission. LTG’s unique mechanism of action compared to other anti-epileptic drugs has led to the investigation of its use in treating other CNS disorders, such as neuropathic pain, PTSD, and major depressive disorder. Furthermore, the drug has been combined with other anti-epileptic drugs and mood stabilizers, which may enhance its therapeutic effects. In conclusion, LTG’s potential to modulate multiple neurotransmitters and ion channels in the CNS makes it a promising drug for treating various neurological disorders. As our understanding of its mechanism of action in the CNS continues to evolve, the potential for the drug to be used in new indications will also be explored.

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“…This drug selectively binds and inhibits voltage-gated sodium channels, characterized by being an anti-seizure/anti-epileptic drug, also used in bipolar I disorder [ 31 ]. In persistent depression, lamotrigine was also reported to be possibly effective for the treatment of individuals with persistent depression who were antidepressant resistant [ 32 ]. A meta-analysis also concluded that this drug was also better than the placebo in improving unipolar and bipolar depressive symptoms [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Serotonin Type 3 Receptor Is Potentially Involved in Cellular Stress Induced by Hydrogen Peroxide

Correia

Silva

Oliveira

et al. 2022

Life

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Depression is a disease with several molecular mechanisms involved, such as problems in the serotonergic pathway. This disease is very complex and prevalent, and thus important to deeply study and aim to overcome high rates of relapse and therapeutic failure. In this study, two cellular lines were used (HT-22 and SH-SY5Y cells) to gain insight about the role of the serotonin type 3 (5-HT3) receptor in cellular stress induced by hydrogen peroxide and/or corticosterone. In research, these compounds are known to mimic the high levels of oxidative stress and dysfunction of the hypothalamus–hypophysis–adrenal axis by the action of glucocorticoids, usually present in depressed individuals. The receptor 5-HT3 is also known to be involved in depression, previously demonstrated in studies that highlight the role of these receptors as promising targets for antidepressant therapy. Indeed, the drugs used in this work (mirtazapine, scopolamine, and lamotrigine) interact with this serotonergic receptor. Thus, by using cell morphology, cell viability (neutral red and MTT), and HPLC assays, this work aimed to understand the role of these drugs in the stress induced by H2O2/corticosterone to HT-22 and SH-SY5Y cell lines. We concluded that the antagonism of the 5-HT3 receptor by these drugs may be important in the attenuation of H2O2-induced oxidative stress to the cells, but not in the corticosterone-induced stress.

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The effectiveness of lamotrigine for persistent depressive disorder: A case report

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 17 publications

Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Serotonin Type 3 Receptor Is Potentially Involved in Cellular Stress Induced by Hydrogen Peroxide

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