The Effectiveness of Local Atorvastatin in the Treatment of Moderate Periodontitis

khoder, Mayada M.; Girgis, Germin N.S.; Anees, Mohamed M.; Youssef, Jilan M.

doi:10.21474/ijar01/10080

Cited by 2 publications

(2 citation statements)

References 64 publications

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“…To minimize the possibility of bacterial recolonization resulting from the conventional therapy limitations, additional therapeutic agents have been used complementary with scaling and root planing (SRP) but unfortunately have some unwanted effects. Local drug delivery (LDD) systems containing antibiotics, antiseptics, herbal products, and/or osteoregenerative agents have been widely used targeting the diseased site at efficacious concentrations with no systemic effect [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Can Erythropoietin Open a Novel Avenue for Periodontal Regeneration?

Farid,

Ata,

Elhennawy

et al. 2024

Cureus

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Introduction: Periodontitis is a dramatic inflammatory disease, representing vigorous interactions between specific causative pathogens and host immune responses resulting in the activation of the destructive inflammatory cascade with the subsequent irreversible destruction of the teeth-supporting apparatus.Aim: This study aims to evaluate the effect of using erythropoietin (EPO) injectable hydrogel, as an additional therapeutic option to scaling and root planing (SRP) in the treatment of stage II periodontitis patients, and to assess its effect on the level of osteocalcin and interleukin (IL)-1β in the gingival crevicular fluid (GCF).Methodology: A total number of 40 patients clinically diagnosed with stage II periodontitis were included. The participants were allocated into two equal groups: study and control groups. Patients in the control group received SRP, while those in the study group received SRP followed by injectable hydrogel containing EPO. Clinical parameters such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed at baseline and two months post treatment. GCF samples were collected at baseline and two months post treatment from both groups to analyze GCF IL-1β and osteocalcin levels using enzyme-linked immunosorbent assay (ELISA).Results: Significant reductions in all tested clinical parameters were revealed in both groups in comparison to baseline values. A marked significant reduction in GCF IL-1β level was detected in the study group. However, two months post treatment, the osteocalcin level was decreased significantly in both groups.Conclusion: This preliminary study shows great promise for the local application of EPO hydrogel as an adjunct to SRP for the management of stage II periodontitis.

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Section: Introductionmentioning

confidence: 99%

Can Erythropoietin Open a Novel Avenue for Periodontal Regeneration?

Farid,

Ata,

Elhennawy

et al. 2024

Cureus

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“…Although SRP is considered the gold standard in the treatment of periodontitis, it may not remove all the pathogens from the base of deep periodontal pockets because of the complex anatomy of the root and the location of lesions. Therefore, adjunctive therapies have been proposed to improve the NSPT outcomes, 3 such as antibiotics, antiseptics, 4 anti-inflammatory drugs, 5 non-pharmacological agents, and herbal products. 6 …”

Section: Introductionmentioning

confidence: 99%

Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study

Alkayali

Badria

ElBaiomy

et al. 2022

J Adv Periodontol Implant Dent

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Background. The aim of this study was the clinical and laboratory evaluation of using polycaprolactone (PCL) nanofibers loaded with oxytetracycline hydrochloride (OTC) and zinc oxide (ZnO) as an adjunct to mechanical therapy in managing stage II grade A periodontitis patients concerning GCF lipocalin2- levels. Methods. Fifty stage II grade A periodontitis patients (27 women and 23 men, with an age range of 30‒60) were enrolled in the study. The patients were randomly assigned to five equal groups and treated with scaling and root planing (SRP), followed by local application of PCL nanofibers: group I: SRP + PCL loaded with OTC and ZnO, group II: SRP + PCL loaded with OTC, group III: SRP + PCL loaded with ZnO, group IV: SRP + unloaded PCL, and group V: SRP alone. Additionally, 10 healthy subjects with healthy periodontium (group VI) (age- and gender-matched) served as the negative control. Nanofibers were applied in the selected pockets of periodontitis patients in groups I to IV once weekly for two months. All the participants were examined clinically by assessing periodontal indices (gingival index, plaque index, pocket depth, and clinical attachment level), and biochemically by assessing GCF lipocalin-2 levels. Results. Compared to controls, periodontitis groups (I, II, III, IV, and V) showed significant elevation of both clinical parameters and GCF lipocalin2- levels at baseline. In addition, these parameters improved significantly after treatment, which was more pronounced in groups I, II-, and III) compared to groups IV and V. However, it did not reach normal values. Conclusion. In association with SRP, PCL nanofibers loaded with OTC and ZnO had beneficial therapeutic effects at both clinical and laboratory levels.

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The Effectiveness of Local Atorvastatin in the Treatment of Moderate Periodontitis

Cited by 2 publications

References 64 publications

Can Erythropoietin Open a Novel Avenue for Periodontal Regeneration?

Can Erythropoietin Open a Novel Avenue for Periodontal Regeneration?

Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study

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