The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam

Abstract

AIM:This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.METHODS:We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nine’s Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly.RESULTS:A complete response (CR) was seen in 24 out of 29 PLC patients (82.8%) with a mean cumulative dose of 9760.5 mJ/cm2 after a mean treatment period of 4.6 weeks (13.8 ± 7.4 exposures). Mild side effects were observed: 69% erythema minimum, 55.2% irritation related to dry skin. No severe side effects were seen during the study. No relapses occurred in 24 CR patients within a mean period of 3 months after the last treatment.CONCLUSION:NB-UVB therapy is an effective and safe option for the treatment and management of PLC.

Efficacy and safety of excimer light (308 nm) in the treatment of pityriasis lichenoides chronica

“…The majority of the patients in the current study did not develop any noticeable side effects that required discontinuation of the treatment with only 6% of patients developing irritation, this is less than the side effects reported by a study on 180 patients with PLC treated with nbUVB with 55% developing skin irritation 27 …”

“…The majority of the patients in the current study did not develop any noticeable side effects that required discontinuation of the treatment with only 6% of patients developing irritation, this is less than the side effects reported by a study on 180 patients with PLC treated with nbUVB with 55% developing skin irritation. 27 Although excimer light is a targeted treatment, it has been studied for several generalized conditions (e.g., Psoriasis, vitiligo, and atopic dermatitis). [28][29][30][31] It could be time consuming for the operator, however, if it offers better response and longer remissions than nbUVB then it is worth to be used.…”

Narrowband ultraviolet B phototherapy for pityriasis lichenoides: A real‐life experience

“…The favorable immunotherapeutic effect of NB‐UVB in PL might be explained by these anti‐inflammatory and immunologic alterations 16 . Several studies documented the efficacy of NB‐UVB 3,8,10,17,18 therefore it has been recommended as first‐line treatment option for generalized PL 4 …”

“…In our study, CR was obtained in 66.7% of the PLC patients with a mean cumulative dose of 95 J/cm 2 and with a mean number of 51.2 sessions. Huu et al assessed the efficacy of NB‐UVB treatment with 29 PLC patients and reported that 82.8% of the patients achieved CR with a mean number of 13.8 sessions 17 . Fernandez et al have reported 8 adult PLC patients with diffuse involvement whose disease showed no response to topical therapy.…”

“…The favorable immunotherapeutic effect of NB-UVB in PL might be explained by these anti-inflammatory and immunologic alterations. 16 Several studies documented the efficacy of NB-UVB 3,8,10,17,18 therefore it has been recommended as first-line treatment option for generalized PL. 4 In a study by Ersoy-Evans et al, in which they documented the clinical features of 124 children with PL, it was reported that 77% of the patients had a chronic recurrent course in a median duration of 18.5 months (range: 3-132 months).…”