The effectiveness of Nigella sativa, methotrexate and their combination in the treatment of moderate to severe psoriasis

Ahmed, Jawad; Kadhim, Sheima Nadim; Al-Hamdi, Khalil Ismael

doi:10.5799/ahinjs.01.2014.04.0450

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…A systematic review by Khabbazi [ 53 ] suggested that Nigella sativa might be effective in the treatment of rheumatoid arthritis, especially in animal and in vitro studies, as well as in humans (a decrease in the disease activity score 28 (DAS28) was especially noted). It is also supposed to alleviate the course of other autoimmune diseases, such as autoimmune encephalomyelitis [ 54 ], ulcerative colitis [ 55 ], and psoriasis [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Osowiecka

Myszkowska-Ryciak

2023

Nutrients

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Diet can be a complementary treatment for Hashimoto’s disease by affecting thyroid function and anti-inflammatory properties. It is still unclear which dietary strategy would be the most beneficial. The aim of this systematic review is to examine all the data currently available in the literature on the effects of nutritional intervention on biochemical parameters (anti-thyroid antibody and thyroid hormones levels) and characteristic symptoms in the course of Hashimoto’s thyroiditis. This systematic review was prepared based on PRISMA guidelines. Articles in PubMed and Scopus databases published up to November 2022 were searched. As a result of the selection, out of 1350 publications, 9 were included for further analysis. The nutritional interventions included the following: elimination of gluten (3 articles) or lactose (1 article), energy restriction with or without excluding selected foods (n = 2), consumption of Nigella sativa (n = 2), or dietary iodine restriction (n = 1). The intervention duration ranged from 21 days to 12 months and included individuals with various thyroid function. Of the nine studies, three studies were female only. An improvement was observed during an energy deficit and after the elimination of selected ingredients (e.g., gluten, lactose, or goitrogens), as well as after the intervention of Nigella sativa. These interventions improved antibody levels against peroxidase (anti-TPO), (thyrotropin) TSH, and free thyroxine (fT4). No improvement was seen on the iodine-restricted diet. Varied outcomes of analyzed dietary interventions may be due to the heterogeneous thyroid condition, high variability between patients, and differences in habitual intake of critical nutrients (e.g., iodine, selenium, and iron) in different populations. Therefore, there is a great need for further experimental studies to determine whether any nutritional interventions are beneficial in Hashimoto’s disease.

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Section: Discussionmentioning

confidence: 99%

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Osowiecka

Myszkowska-Ryciak

2023

Nutrients

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“…A little research has shown the topical benefits of NS oil. NS, for example, may be beneficial as a topical therapy for psoriasis [71]. Indomethacin and nanoparticles derived from NS essential oil have been demonstrated to have anti-inflammatory effects [72].…”

Section: Antioxidant and Anti-inflammatorymentioning

confidence: 99%

Potential Pharmacological Applications of Nigella Seeds with a Focus on Nigella sativa and Its Constituents against Chronic Inflammatory Diseases: Progress and Future Opportunities

Wahab,

Alsayari

2023

Plants

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The leading cause of death worldwide has been identified as chronic illnesses, according to the World Health Organization (WHO). Chronic inflammatory conditions such as asthma, cancer, diabetes, heart disease, and obesity account for three out of every five deaths. Although many people benefit from using nonsteroidal anti-inflammatory medicines (NSAIDs) for pain and inflammation relief, there are significant adverse effects to using these medications. Medicinal plants possess anti-inflammatory properties with minimal or no side effects. Nigella sativa (NS), also known as black cumin, is one of the plants used in traditional medicine the most. Many studies on the NS have shown that their therapeutic properties are attributed to the seed, oil, and secondary metabolites. This plant has been studied extensively and has many medical uses, such as anti-inflammatory. NS or its phytochemical compounds, such as thymoquinone, can cause cell apoptosis via oxidative stress, block efflux pumps, enhance membrane permeability, and exert potent biocidal effects. Notwithstanding the extensively documented anti-inflammatory effectiveness observed in the experimental model, the precise mechanisms underlying its anti-inflammatory effects in diverse chronic inflammatory diseases and its multi-targeting characteristics remain largely unexplored. This review examines NS or its secondary metabolites, a valuable source for the therapeutic development of chronic inflammatory diseases. Most clinical studies were done for diabetes and cardiovascular disease; therefore, more studies are required to examine the NS extracts and phytoconstituents to treat cancer, obesity, diabetes, asthma, neurological disorders, and COVID-19. This study will be a significant resource for clinicians and biologists seeking a pharmaceutical solution for inflammatory diseases.

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“…However, there are only a few studies showing the use of Nigella sativa oil topically. For instance, topical Nigella sativa could be effective treatment for psoriasis [13], application of 50% Nigella sativa oil in cream could heal burn wounds in rats [14], while Nigella sativa essential oil nanoparticles have also been shown to have anti-inflammatory properties in combination with indomethacin [15]. The topical use of Nigella sativa oil needs to be developed in the form of a practical dosage form such as a balm stick.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019

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Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

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The effectiveness of Nigella sativa, methotrexate and their combination in the treatment of moderate to severe psoriasis

Cited by 7 publications

References 25 publications

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Potential Pharmacological Applications of Nigella Seeds with a Focus on Nigella sativa and Its Constituents against Chronic Inflammatory Diseases: Progress and Future Opportunities

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

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