The effectiveness of non-invasive brain stimulation on arousal and alertness in patients in coma or persistent vegetative state after traumatic brain injury

Li, Yabin; Luo, Xianggui; Wan, Miao; Li, Jiao; Wang, Hongxia; Wei, Dang; Feng, Haixia

doi:10.1097/md.0000000000012321

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…According to the duration, transient disorder of consciousness lasts less than 1 month, and prolonged is beyond this, however, no clear timeframe to regaining consciousness is established, and spontaneous recovery can occur within the first year and even, in some cases, later (5)(6)(7). pDOC develop in 1-14% of traumatic brain injury (TBI) patients, and 12% in non-traumatic injuries (8).…”

Section: Introductionmentioning

confidence: 99%

Two-year outcomes of patients with prolonged disorders of consciousness: a prospective cohort study in Russian Federation

Nekrasova¹,

Kanarskii²,

Borisov³

et al. 2022

Ann Palliat Med

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Section: Introductionmentioning

confidence: 99%

Two-year outcomes of patients with prolonged disorders of consciousness: a prospective cohort study in Russian Federation

Nekrasova¹,

Kanarskii²,

Borisov³

et al. 2022

Ann Palliat Med

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“…The survival rate of patients with severe craniocerebral injury has improved substantially after treatment attributing to the constant advances in medical technology, but it is often accompanied by sequelae such as disturbance of consciousness. 1 Generally, patients with mild disturbance of consciousness can recover from a brief coma, but a persistent vegetative state (PVS) is a more severe and enduring disturbance of consciousness. 2,3 Therefore, the key goal to treat PVS patients is to regain consciousness and alleviate the disturbance of consciousness as much as possible.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of high-cervical spinal cord stimulation in vegetative patients and its effect on blood flow

Gu¹,

Tan²,

Peng³

et al. 2022

NeuroAsia

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To investigate the efficacy of high-cervical spinal cord stimulation in vegetative patients and its effect on blood flow. Sixty patients with persistent vegetative state were assigned in a control group (n=30) for routine coma arousal program and a treatment group (n=30) for high-cervical spinal cord stimulation besides routine coma arousal program using a random number table method. The number of patients out from vegetative state, consciousness (Coma Recovery Scale-revised), electroencephalogram, brainstem auditory evoked potential, somatosensory evoked potential and cerebral blood flow were observed before and post treatment. One patient in the control group while seven patients in the treatment group were out from vegetative state 6 months after treatment (P<0.05). Post-treatment Coma Recovery Scale-Revised scores increased in both groups of patients (9.23±2.78 vs 4.43±1.06 and 7.12±2.91 vs 4.51±1.16, P<0.001), with a more evident increase in the treatment group than in the control group (9.23±2.78 vs 7.12±2.91, P<0.01). Electroencephalogram, brainstem auditory evoked potential and somatosensory evoked potential enhanced post treatment (all P<0.01), with greater improvements in the treatment group (all P<0.01). Cerebral blood flow rose in both groups post treatment (56.32±5.88 vs 44.22±5.21 and 51.12±5.56 vs 44.99±5.32, P<0.001), with a more distinct increase in the treatment group than in the control group (56.32±5.88 vs 51.12±5.56, P<0.001). High-cervical spinal cord stimulation for patients with persistent vegetative state can promote the recovery of consciousness, enhance neuroelectrophysiological activity and improve cerebral blood flow. However, more clinical studies are needed to confirm its efficacy.

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“…MSC chronization is usually not emphasized [ 6 ]. Persistent DOC develops in 1–14% of TBI patients, and around 12% in non-traumatic injuries [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

One-Year Demographical and Clinical Indices of Patients with Chronic Disorders of Consciousness

et al. 2021

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This work aims to evaluate the prognostic value of the demographical and clinical data on long-term outcomes (up to 12 months) in patients with severe acquired brain injury with vegetative state/unresponsive wakefulness syndrome (VS/UWS/UWS) or a minimally conscious state (MCS). Patients (n = 211) with VS/UWS/UWS (n = 123) and MCS (n = 88) were admitted to the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology after anoxic brain injury (n = 53), vascular lesions (n = 59), traumatic brain injury (n = 93), and other causes (n = 6). At the beginning of the 12-month study, younger age and a higher score by the Coma Recovery Scale-Revised (CRS-R) predicted a survival. However, no reliable markers of significant positive dynamics of consciousness were found. Based on the etiology, anoxic brain injury has the most unfavorable prognosis. For patients with vascular lesions, the first three months after injury have the most important prognostic value. No correlations were found between survival, increased consciousness, and gender. The demographic and clinical characteristics of patients with chronic DOC can be used to predict long-term mortality in patients with chronic disorders of consciousness. Further research should be devoted to finding reliable predictors of recovery of consciousness.

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The effectiveness of non-invasive brain stimulation on arousal and alertness in patients in coma or persistent vegetative state after traumatic brain injury

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 35 publications

Two-year outcomes of patients with prolonged disorders of consciousness: a prospective cohort study in Russian Federation

Two-year outcomes of patients with prolonged disorders of consciousness: a prospective cohort study in Russian Federation

Efficacy of high-cervical spinal cord stimulation in vegetative patients and its effect on blood flow

One-Year Demographical and Clinical Indices of Patients with Chronic Disorders of Consciousness

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