The effectiveness of resveratrol in treatment of PCOS on the basis of experimental model in rats

Yarmolinskaya, Maria I.; Bulgakova, Olga L.; Abashova, Elena I.; Borodina, Valentina L.; Tral, Tatyana G.

doi:10.1080/09513590.2021.2014665

Cited by 12 publications

(5 citation statements)

References 17 publications

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“…Numerous animal studies were performed regarding the effect of resveratrol on PCOS phenotype (Table 1) [136][137][138][139][140][141][142][143][144][145][146][147][148]. The majority of studies reported a beneficial effect of resveratrol on ovary morphology (improved follicular development) [137,138,[141][142][143][144][145][146]148] body weight (fat) loss or shrinkage of adipocytes [136,138,141,143,145,148], and improved estrus cyclicity [136,143,145,146,148]. Additionally, improvement of the hormone profile or individual hormones [137,138,143,144,146,148], insulin sensibility [137,139,142,147,148], and oxidative stress were reported [137]…”

Section: Animal Studiesmentioning

confidence: 99%

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

Podgrajsek,

Ban Frangez,

Stimpfel

2024

IJMS

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Resveratrol is a polyphenol present in various plant sources. Studies have reported numerous potential health benefits of resveratrol, exhibiting anti-aging, anti-inflammatory, anti-microbial, and anti-carcinogenic activity. Due to the reported effects, resveratrol is also being tested in reproductive disorders, including female infertility. Numerous cellular, animal, and even human studies were performed with a focus on the effect of resveratrol on female infertility. In this review, we reviewed some of its molecular mechanisms of action and summarized animal and human studies regarding resveratrol and female infertility, with a focus on age-related infertility, polycystic ovary syndrome, and endometriosis.

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Section: Animal Studiesmentioning

confidence: 99%

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

Podgrajsek,

Ban Frangez,

Stimpfel

2024

IJMS

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“…Group 3 was marked as DDP-4i treated group, receiving sitagliptin as 10 mg/kg/day for whole study period. Groups 4 and 5 were designated as LUT and RES group, respectively, as they received lutein 40 mg/kg 34 and resveratrol 30 mg/kg, 35 respectively, for the same study period. While groups 6 and 7 received combination treatment of DPP-4i + LUT (10 mg/kg/ day +40 mg/kg) and DPP-4i + RES (10 mg/kg/day +30 mg/ kg), respectively, for the defined study period.…”

Section: Experimental Animal Modelmentioning

confidence: 99%

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

et al. 2022

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This study was aimed to investigate the therapeutic potentials of plant-based bioactive compounds; lutein and resveratrol alone and/or in combination with DPP-4 enzyme inhibitor; sitagliptin on the secretion and bioavailability of Glucagon like peptide-1(GLP). For this, experimental rats were divided into seven groups. Group 1 was marked as control, while other six groups received streptozotocin (60 mg/kg I.P.). Later, group 2 was kept disease-control. While group 3 received 10 mg/kg/day sitagliptin (DDP-4i). Group 4 received 40 mg/kg/day lutein (LUT) and group 5 received 30 mg/kg/day resveratrol (RES). While group 6 and 7 were received combination of DPP-4i+LUT and DPP-4i+RES, respectively. Combined administration of DPP-4i+LUT or DPP-4i+RES showed expected therapeutic effects by lowering the fasting blood glucose and maintaining the serum insulin concentrations with improved glucose sensitivity and reduced insulin resistance. Further, co-administration of LUT and RES with DPP-4i revealed beneficial effects on measures of insulin resistance, circulating lipids, glycemic index, oxidative stress, and inflammatory status along with restoration of histological morphology of pancreatic cells and enterocytes that seemed to improve the level of GLP-1. Hence, substantial verdicts of this study showing therapeutic potentials of LUT and RES would surely help to recognize the potential effects in combination with DPP-4i as stimulators of GLP-1 secretion.

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“…In a study conducted by Yarmolinskaya et al [19], letrozole-induced PCOS Wistar rats received resveratrol at 20 mg/kg and 30 mg/kg doses for 30 days. Resveratrol was found to have dose-dependent effects on the normalization of ovarian tissue morphology, regularity of estrous cycle, and decreased bodyweight, suggesting that it may be a useful therapeutic option for the treatment of PCOS.…”

Section: Pcos Markers Including Hormonesmentioning

confidence: 99%

“…More recent studies on the physiological effects of resveratrol have explored the potential of antiaging and antidiabetic properties of the molecule [18]. Mouse models administered with resveratrol have shown an improvement in glucose homeostasis and insulin resistance [19]. Ovarian morphology was improved in terms of atretic and secondary follicles and the decreased number of Graafian follicles in the PCOS group after treatment with resveratrol.…”

Section: Introductionmentioning

confidence: 99%

Effects of Resveratrol on Metabolic, Biochemical, and Endocrine Manifestations in Polycystic Ovary Syndrome

2022

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Polycystic Ovary Syndrome (PCOS) is a reproductive, hormonal, and metabolic disorder frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. Resveratrol is a naturally occurring polyphenolic stilbene found in trace amounts in some food items. It has been extensively used as a treatment option for metabolic disorders but its use in PCOS treatment has been limited. This review emphasizes the effect of resveratrol on the clinical features of PCOS, ovarian morphology, androgen profile, markers of oxidative stress, inflammatory markers, and metabolic markers associated with PCOS.

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The effectiveness of resveratrol in treatment of PCOS on the basis of experimental model in rats

Cited by 12 publications

References 17 publications

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

Effects of Resveratrol on Metabolic, Biochemical, and Endocrine Manifestations in Polycystic Ovary Syndrome

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