The Effectiveness of Standard Single Dose Omeprazole vs. High Dose Continuous Infusion in High-risk Critically Ill Patients

Ibrahim, Ezzeldin S; Koptan, Hala M

doi:10.4172/2155-6148.1000819

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…This result was not statistically significant. 17 Furthermore, Ibrahim et al 18 carried out a randomized double-blind study to compare the advantage of high and standard- dose omeprazole (IV omeprazole 40 mg bolus dose once daily followed by normal saline infusion vs IV bolus of 80 mg omeprazole followed by 8 mg/h infusion) as prophylaxis against upper GIT bleeding in high risk critically ill patients. It was found that patients on high dose omeprazole had higher gastric pH, lower incidence of critical significant GIT bleeding, higher ICU stay Hb, lower number of RBCs transfusion and shorter ICU stay.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Alzubaidi

Basilim²

2022

SMJ

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Section: Discussionmentioning

confidence: 99%

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Alzubaidi

Basilim²

2022

SMJ

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Analysis of stress ulcer prophylaxis drug regimentation in surgical patients

Wijaya

Suharjono

Matulatan

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives The World Health Organization (WHO) estimated that more than 50% of drugs were prescribed incorrectly, including stress ulcer prophylaxis (SUP) drugs. Prescribing SUP drugs in incorrect doses and frequencies are considered irrational, and may affects to the effectivity of the therapy. This research aimed to assess the appropriateness of the SUP drugs regimentation in the inpatient surgery room at Dr. Soetomo Hospital, Surabaya, Indonesia. Methods This research was cross-sectional study and conducted for 4 weeks in 2019 in the inpatient surgery room of Dr. Soetomo Hospital. The population was SUP drugs that were prescribed in inpatient surgery room. Those SUP drugs with indications for the prevention of stress-induced ulcers that complied to the terms listed on the American Society of Health-System Pharmacists (ASHP) were included as the samples, and vice versa. The samples then assessed for their regimentation appropriateness using the dose and frequency standard of ASHP. Results There were 224 dose units taken as sample, from the total population of 1,404 SUP drugs. The result showed that as much as 48.2% of SUP medications were given to the patients in inappropriate regimentation. Of that number, all ranitidine injection were inappropriately regimented. On the contrary all omeprazole injection dose units were appropriately regimented, meanwhile the amount of appropriate regimentation of sucralfate suspension were 74.6%. Conclusions According to ASHP standard, the SUP drugs in the inpatient surgery room at Dr. Soetomo Hospital were mostly given in inappropriate regimentation. Further research is needed to explore how will those inappropriate regimentation affect on the efficacy of therapy in the patients.

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The Effectiveness of Standard Single Dose Omeprazole vs. High Dose Continuous Infusion in High-risk Critically Ill Patients

Cited by 2 publications

References 16 publications

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Analysis of stress ulcer prophylaxis drug regimentation in surgical patients

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