The effectiveness of the combined use of topical glucocorticosteroid and photodynamic therapy in vulvar lichen sclerosus

Суркичин, С. И.; Круглова, Л. С.; Apolikhina, I.A. Apolikhina

doi:10.18565/pharmateca.2022.14.41-47

Pharmateca

2022

DOI: 10.18565/pharmateca.2022.14.41-47

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The effectiveness of the combined use of topical glucocorticosteroid and photodynamic therapy in vulvar lichen sclerosus

С. И. Суркичин¹,

Л. С. Круглова²,

I.A. Apolikhina Apolikhina³

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2023

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Photodynamic therapy in the treatment of vulvar lichen sclerosus et atrophicus

Surkichin,

Kruglova,

Apolikhina

2023

Physiotherapist

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Lichen sclerosus (LS) is a chronic inflammatory disease that is 6–10 times more common in women than in men. LS affects between 1 in 1,000 and 1 in 300 people in the general population, but the exact prevalence is unknown since the disease is often asymptomatic. Objective: to evaluate the effectiveness of PDT in patients with LS in comparison with standard therapy methods. Material and methods: The study included 45 patients diagnosed with LS aged from 45 to 72 years (median age was 59 years). Depending on the therapy performed, the groups were divided into subgroups: Group 1A — patients with LS who were prescribed therapy with external glucocorticoids, Group 1B — patients with LS who were prescribed photodynamic therapy, Group 1C — patients with LS who were prescribed combined treatment: external glucocorticoids + PDT. Results: The study developed a special visual analogue scale to assess the objective condition of the vulva. VAS included the following parameters: pigmentation, skin pattern, turgor (skin fold straightening time), presence of cracks or erosions, and moisture. According to the data obtained, a complex treatment method using photodynamic therapy in patients with vulvar lichen sclerosus et atrophicus causes a higher effect than drug therapy and mono-PDT, which is confirmed by the dynamics of the total VAS index: 50.8 % compared with 28.2 % and 35.1 % in the comparison groups, respectively, therefore, it can be recommended for use in practical healthcare.

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Photodynamic therapy in the treatment of vulvar lichen sclerosus et atrophicus

Surkichin,

Kruglova,

Apolikhina

2023

Physiotherapist

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show abstract

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The effectiveness of the combined use of topical glucocorticosteroid and photodynamic therapy in vulvar lichen sclerosus

Cited by 1 publication

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Photodynamic therapy in the treatment of vulvar lichen sclerosus et atrophicus

Photodynamic therapy in the treatment of vulvar lichen sclerosus et atrophicus

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