The Effectiveness of the Gastro-esophageal Reflux Disease Treatment in Persons who have Completed Successful Chronic Hepatitis C Antiviral Therapy at the Rehabilitation Stage

Abstract

Aim: To assess the effectiveness of the physiopharmacological treatment of GERD in persons who successfully completed a full course of CHC therapy with direct antiviral drugs no more than 6 months ago. Materials and Methods: 67 people with GERD who completed a course of CHC therapy with direct antiviral drugs no more than 6 months ago were under observation. The patients were divided into: 1 group (n=20) – received rabeprazole 20 mg in the morning 40 minutes before meals, 2 group (n=23) – rabeprazole 20 mg in combination with taking mineral water “Polyana Kvasova” according to the proposed scheme, group 3 (n=24 patients) – took rabeprazole 20 mg in combination with MV«Polyana Kvasova» for 24 days, and with a course of magnetic therapy procedures. Results: Under the influence of treatment, on the 24 th day of observation, all 100% of patients in the 3rd group had positive dynamics: the elimination of heartburn (p<0.001), pain in the epigastrium (p<0.001), and manifestations of dysphagia (p<0.001), which were confirmed by fibrogastroscopy - disappearance of esophagitis (p<0.001) and gastroesophageal reflux (p<0.001). In 80% of the patients of the second group, positive dynamics of the clinical and endoscopic picture was also observed (p<0.005), and in the rest of the patients, the improvement was unreliable (p>0.05). After the treatment, a decrease in manifestations of asthenovegetative and dyspeptic syndromes, cholestatic syndrome was recorded in all groups of patients, with a predominance in group 3. Conclusions: The use of complex physiopharmacological treatment has a reliable advantage over standard pharmacological treatment, as it has a positive effect not only on GERD manifestations, but also on clinical and laboratory manifestations of CHC and improves the quality of life.