Topicality. Metabolic syndrome is an urgent issue and a serious health risk not only for adults but also for children, adolescents, and young people. An essential role in the metabolic syndrome emergence is played by the negative “achievements” of progress such as low physical activity, increased caloric intake, and chronic stress. All these factors cause a steady increase in arterial hypertension, obesity, dyslipidemia, and diabetes. There is significant evidence that obesity and chronic pain are closely related. Chronic pain is one of the main causes of weight gain of obese patients. The Research Aims to determine the intensity of musculoskeletal pain in young women with metabolic syndrome and the localization of their maximum pain, as well as to investigate the correlation between the intensity of pain depending on the location and indicators of body weight, body mass index, waist-to-hip ratio, waist circumference, and body length. Research Methods. To identify the subjective pain sensation according to the domain of the International Classification of Functioning, Disability and Health b.280 – pain sensation, a visual analog pain scale was used in patients; to establish a correlation between pain intensity and pain localization in young women with metabolic syndrome, body weight, body mass index, and waist-to-hip ratio, as well as the ratio of waist circumference to body length were additionally calculated based on bioelectrical impedance. Research Results. According to the results of the responses, we can note that among the surveyed young women with metabolic syndrome, only 3,09 % indicated that they had practically no pain with localization in the neck, back, lumbar region, or joints. In general, we can state that in many cases it has been found that the manifestation of pain in women with metabolic syndrome in the back averages 4.8±1,5 cm (▁x±S), which corresponds to the level of “moderate” pain. A comparison of the subjects’ pain scores during the worst period, which was performed using the nonparametric Kruskal-Wallis H test, showed that its intensity was statistically significant (H (3, N= 388) =87,69; p<0,05) depending on the localization. Conclusions. The obtained results prove that both overweight and abdominal obesity have negative effects on the manifestation of pain syndrome among women in the first period of adulthood but abdominal obesity has a stronger effect on its intensity. In particular, this type of obesity harms the lumbar spine of the subjects.