The effectiveness of transdermal testosterone gel 1% (androgel) for poor responders undergoing <i>in vitro</i> fertilization

Doan, Hang Thi; Quan, Lam Hoang

doi:10.1080/09513590.2017.1332586

Cited by 24 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports have also assessed the efficacy of administering the bioactive androgen, testosterone, in POR patients to improve ovarian response and IVF outcomes (Table 3). Although four RCTs (two with placebo controls) assessing the impact of transdermal testosterone administration for 5-20 days in POR patients showed no significant effect of testosterone pre-treatment (Massin et al 2006, Fabregues et al 2009, Sipe et al 2010, Bosdou et al 2016, since then numerous studies, including a placebo-controlled RCT, have reported on a range of beneficial effects of pre-IVF testosterone pre-treatment (Balasch et al 2006, Kim et al 2011, Mitri et al 2016, Doan et al 2017, Saharkhiz et al 2018. These beneficial effects include improved antral follicle numbers, oocyte retrieval numbers, fertilization rates, embryo implantation rates, embryo quality, clinical pregnancy rates and live birth rates in some women (observations from studies summarized in Table 3).…”

Section: Testosteronementioning

confidence: 99%

Androgens and ovarian function: translation from basic discovery research to clinical impact

Walters

Paris

Aflatounian

et al. 2019

Journal of Endocrinology

View full text Add to dashboard Cite

In the last decade, it has been revealed that androgens play a direct and important role in regulating female reproductive function. Androgens mediate their actions via the androgen receptor (AR), and global and cell-specific Ar-knockout mouse models have confirmed that AR-mediated androgen actions play a role in regulating female fertility and follicle health, development and ovulation. This knowledge, along with the clinical data reporting a beneficial effect of androgens or androgen-modulating agents in augmenting in vitro fertilization (IVF) stimulation in women termed poor responders, has supported the adoption of this concept in many IVF clinics worldwide. On the other hand, substantial evidence from human and animal studies now supports the hypothesis that androgens in excess, acting via the AR, play a key role in the origins of polycystic ovary syndrome (PCOS). The identification of the target sites of these AR actions and the molecular mechanisms involved in underpinning the development of PCOS is essential to provide the knowledge required for the future development of novel, mechanism-based therapies for the treatment of PCOS. This review will summarize the basic scientific discoveries that have enhanced our knowledge of the roles of androgens in female reproductive function, discuss the impact these findings have had in the clinic and how a greater understanding of the role androgens play in female physiology may shape the future development of effective strategies to improve IVF outcomes in poor responders and the amelioration of symptoms in patients with PCOS.

show abstract

Section: Testosteronementioning

confidence: 99%

Androgens and ovarian function: translation from basic discovery research to clinical impact

Walters

Paris

Aflatounian

et al. 2019

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Of these, 936 records were excluded after title/ abstract screening (not relevant to the review). We examined the full text of 18 remaining manuscripts, and, of these, we excluded 10 papers-one paper due to the lack of data concerning CPR and/or LBR [27], one trial reported data not analyzable [28], three papers because the design was observational [29][30][31], and six papers because they were review/metaanalysis [11-13, 21, 32, 33]. Finally, 7 manuscripts were included in the meta-analysis [10,[22][23][24][34][35][36].…”

Section: Study Selectionmentioning

confidence: 99%

Testosterone therapy for women with poor ovarian response undergoing IVF: a meta-analysis of randomized controlled trials

Noventa

Vitagliano

Andrisani

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

The aim of the present systematic review and meta-analysis was to summarize evidence on the effectiveness of testosterone supplementation for poor ovarian responders (POR) on IVF outcomes. The primary outcome was live birth rate (LBR); secondary outcomes were clinical pregnancy rate (CPR), miscarriage rate (MR), total and MII oocytes, and total embryos. Methods This meta-analysis of randomized controlled trials (RCTs) evaluates the effects of testosterone administration before/ during COS compared with a control group in patients defined as POR. The primary outcome was live birth rate (LBR); secondary outcomes were clinical pregnancy rate (CPR), miscarriage rate (MR), total and MII oocytes, and total embryos. Pooled results were expressed as risk ratio (RR) or mean differences (MD) with 95% confidence interval (95% CI). Sources of heterogeneity were investigated through sensitivity and subgroup analysis. All analyses were performed by using the randomeffects model. Results Women receiving testosterone showed higher LBR (RR 2.29, 95% CI 1.31-4.01, p = 0.004), CPR (RR 2.32, 95% CI 1.47-3.64, p = 0.0003), total oocytes (MD = 1.28 [95% CI 0.83, 1.73], p < 0.00001), MII oocytes (MD = 0.96 [95% CI 0.28, 1.65], p = 0.006), and total embryos (MD = 1.17 [95% CI 0.67, 1.67], p < 0.00001) in comparison to controls, with no difference in MR (p = ns). Sensitivity and subgroup analysis did not provide statistical changes to the pooled results. Conclusions Testosterone therapy seems promising to improve the success at IVF in POR patients. Further RCTs with rigorous methodology and inclusion criteria are still mandatory.

show abstract

“…Recent studies have also been focusing on the pretreatment effect of androgens for POR patients before receiving IVF. However, contradictory results were reported that some studies con rmed the e cacy of androgens in enhancing live birth rate [19][20][21], and some negated the conclusion [19,22]. This could be partly accounted for by the differences in study populations and timing and duration of androgens pre-treatment.…”

Section: Discussionmentioning

confidence: 99%

A Proper Increasing in the Testosterone Level May Be Associated With Better Pregnancy Outcomes for in Vitro Fertilization (IVF)/intracytoplasmic Sperm Injection (ICSI) Patients With Tubal or Male Infertility

Chen¹,

Zhang²,

Sun³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background To investigate the relationship between androgen levels and pregnancy outcomes in patients with tubal or male infertility at different times of the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Methods Patients with tubal or male infertility but normal androgen levels receiving IVF/ICSI were continuously recruited. We made longitudinal analysis of the testosterone (T) levels at three time points (T0: basal T levels, T1: T levels on the trigger day, T2: T levels on the next day of the trigger day) in three groups with different pregnancy outcomes (Group 1: no pregnancy, Group 2: clinical pregnancy but no live birth, Group 3: live birth) as repeated measurement data using linear mixed effect models. We also plotted fitting curves depicting the relationship of the T levels and the numbers of oocytes retrieved at different time points, and the inflection points of the curves were identified. Results A total of 3012 patients were recruited in the study. Improvements in androgen levels were identified at the three-time points in Group 1 and 3. The slope in Group 3 after refitting was significantly higher than Group 1 (P = 0.000). The curves that reflected the association of androgen levels and numbers of retrieved oocytes presented an upward trend before a certain inflection point, after which the curves had no obvious changes or fell with the increase of androgen levels. The inflection points for T0, T1, T2 were calculated as 0.45, 0.94, 1.09, respectively. Conclusion The faster upward trend of the T levels might be associated with better pregnancy outcomes. Within the range of lower than a certain value of the T levels, more oocytes and embryos could be obtained with the increasing of the T levels.

show abstract

The effectiveness of transdermal testosterone gel 1% (androgel) for poor responders undergoing in vitro fertilization

Cited by 24 publications

References 7 publications

Androgens and ovarian function: translation from basic discovery research to clinical impact

Androgens and ovarian function: translation from basic discovery research to clinical impact

Testosterone therapy for women with poor ovarian response undergoing IVF: a meta-analysis of randomized controlled trials

A Proper Increasing in the Testosterone Level May Be Associated With Better Pregnancy Outcomes for in Vitro Fertilization (IVF)/intracytoplasmic Sperm Injection (ICSI) Patients With Tubal or Male Infertility

Contact Info

Product

Resources

About